Atomistry » Zinc » PDB 2omg-2ovx » 2orv
Atomistry »
  Zinc »
    PDB 2omg-2ovx »
      2orv »

Zinc in PDB 2orv: Human Thymidine Kinase 1 in Complex with TP4A

Enzymatic activity of Human Thymidine Kinase 1 in Complex with TP4A

All present enzymatic activity of Human Thymidine Kinase 1 in Complex with TP4A:
2.7.1.21;

Protein crystallography data

The structure of Human Thymidine Kinase 1 in Complex with TP4A, PDB code: 2orv was solved by D.Segura-Pena, S.Lutz, C.Monnerjahn, M.Konrad, A.Lavie, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.50 / 2.30
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 80.980, 80.980, 156.360, 90.00, 90.00, 120.00
R / Rfree (%) 19.7 / 24.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Thymidine Kinase 1 in Complex with TP4A (pdb code 2orv). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Thymidine Kinase 1 in Complex with TP4A, PDB code: 2orv:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 2orv

Go back to Zinc Binding Sites List in 2orv
Zinc binding site 1 out of 2 in the Human Thymidine Kinase 1 in Complex with TP4A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Thymidine Kinase 1 in Complex with TP4A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn235

b:66.5
occ:1.00
SG A:CYS156 2.0 61.8 1.0
SG A:CYS188 2.3 64.8 1.0
SG A:CYS153 2.5 55.9 1.0
SG A:CYS185 2.5 54.8 1.0
CB A:CYS156 3.1 63.0 1.0
CB A:CYS188 3.2 62.3 1.0
CB A:CYS153 3.3 55.0 1.0
N A:CYS156 3.6 63.3 1.0
CB A:CYS185 3.7 53.8 1.0
CA A:CYS156 3.9 63.3 1.0
N A:CYS188 4.1 62.9 1.0
N A:CYS185 4.1 52.9 1.0
CA A:CYS188 4.2 62.7 1.0
CA A:CYS185 4.4 53.9 1.0
C A:GLU155 4.6 62.1 1.0
C A:CYS156 4.6 64.1 1.0
N A:PHE157 4.6 64.9 1.0
CA A:CYS153 4.7 55.1 1.0
N A:ARG158 4.9 65.0 1.0
CB A:GLU155 4.9 60.8 1.0
C A:CYS185 5.0 54.4 1.0
O A:CYS185 5.0 54.3 1.0
CB A:ARG158 5.0 64.2 1.0

Zinc binding site 2 out of 2 in 2orv

Go back to Zinc Binding Sites List in 2orv
Zinc binding site 2 out of 2 in the Human Thymidine Kinase 1 in Complex with TP4A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Thymidine Kinase 1 in Complex with TP4A within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn235

b:60.5
occ:1.00
SG B:CYS156 2.3 59.6 1.0
SG B:CYS153 2.4 56.5 1.0
SG B:CYS188 2.4 60.8 1.0
SG B:CYS185 2.5 53.6 1.0
CB B:CYS156 3.2 62.8 1.0
CB B:CYS188 3.2 61.0 1.0
CB B:CYS153 3.3 55.3 1.0
CB B:CYS185 3.5 53.3 1.0
N B:CYS156 3.8 62.9 1.0
CA B:CYS156 4.0 62.3 1.0
N B:CYS185 4.0 53.3 1.0
N B:CYS188 4.2 61.2 1.0
CA B:CYS188 4.3 61.1 1.0
CA B:CYS185 4.3 53.2 1.0
C B:CYS156 4.5 63.1 1.0
C B:GLU155 4.6 62.2 1.0
N B:PHE157 4.6 63.7 1.0
CA B:CYS153 4.7 55.8 1.0
N B:ARG158 4.7 63.4 1.0
NH1 A:ARG18 4.8 82.3 1.0
CB B:ARG158 4.9 63.1 1.0
CB B:GLU155 4.9 61.2 1.0
C B:CYS185 4.9 53.9 1.0
CG B:ARG158 5.0 66.5 1.0

Reference:

D.Segura-Pena, S.Lutz, C.Monnerjahn, M.Konrad, A.Lavie. Binding of Atp to TK1-Like Enzymes Is Associated with A Conformational Change in the Quaternary Structure. J.Mol.Biol. V. 369 129 2007.
ISSN: ISSN 0022-2836
PubMed: 17407781
DOI: 10.1016/J.JMB.2007.02.104
Page generated: Thu Oct 17 02:44:45 2024

Last articles

Zn in 9FD2
Zn in 9GUW
Zn in 9GUX
Zn in 9F7C
Zn in 9GUR
Zn in 9F7A
Zn in 9DDE
Zn in 9DBY
Zn in 9EBZ
Zn in 9DGG
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy