Zinc in PDB 2nup: Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B

The structure of Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B, PDB code: 2nup was solved by J.D.Mancias, J.Goldberg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.80
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	148.200, 97.400, 129.620, 90.00, 90.23, 90.00
R / Rfree (%)	20.2 / 27.5

The binding sites of Zinc atom in the Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B (pdb code 2nup). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B, PDB code: 2nup:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn800 b:47.4 occ:1.00 SG A:CYS66 2.3 41.3 1.0 SG A:CYS85 2.4 45.2 1.0 SG A:CYS61 2.5 44.5 1.0 SG A:CYS88 2.6 45.6 1.0 CB A:CYS66 3.0 47.7 1.0 CB A:CYS85 3.0 32.7 1.0 CB A:CYS61 3.4 43.3 1.0 CB A:CYS88 3.7 47.8 1.0 N A:CYS88 3.9 49.5 1.0 N A:ARG67 4.3 48.0 1.0 CB A:GLN90 4.3 62.2 1.0 CA A:CYS88 4.3 48.9 1.0 CA A:CYS66 4.4 49.2 1.0 CA A:CYS85 4.5 37.3 1.0 N A:ALA68 4.5 47.1 1.0 CB A:PHE87 4.6 50.5 1.0 C A:CYS66 4.7 49.1 1.0 CB A:ALA68 4.8 40.4 1.0 CA A:CYS61 4.8 43.5 1.0 C A:PHE87 4.8 50.1 1.0 CB A:ARG63 4.9 59.1 1.0 C A:CYS88 4.9 50.2 1.0 N A:GLN90 4.9 61.6 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Human SEC23A/24A Heterodimer, Complexed with the Snare Protein SEC22B within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1100 b:34.7 occ:1.00 SG B:CYS431 2.4 54.6 1.0 SG B:CYS452 2.4 40.0 1.0 SG B:CYS455 2.4 35.9 1.0 SG B:CYS434 2.4 28.6 1.0 CB B:CYS452 3.1 33.1 1.0 CB B:CYS455 3.2 30.0 1.0 CB B:CYS431 3.3 50.8 1.0 CB B:CYS434 3.4 30.4 1.0 N B:CYS434 3.5 37.1 1.0 N B:CYS455 3.8 35.2 1.0 CA B:CYS455 3.9 34.5 1.0 CA B:CYS434 4.0 30.1 1.0 CB B:SER433 4.1 45.0 1.0 C B:CYS455 4.3 39.2 1.0 C B:SER433 4.6 40.0 1.0 CA B:CYS452 4.6 34.1 1.0 N B:ARG457 4.7 45.5 1.0 CB B:ARG457 4.7 43.5 1.0 OG1 B:THR436 4.7 24.1 1.0 O B:CYS455 4.7 44.2 1.0 C B:CYS434 4.7 29.3 1.0 N B:TYR456 4.7 43.1 1.0 CA B:SER433 4.7 40.8 1.0 CA B:CYS431 4.7 51.1 1.0 N B:SER433 4.8 45.6 1.0 C B:LEU454 4.8 35.9 1.0 CB B:THR436 4.8 17.8 1.0 N B:ARG435 4.9 26.9 1.0

J.D.Mancias, J.Goldberg. The Transport Signal on SEC22 For Packaging Into Copii-Coated Vesicles Is A Conformational Epitope Mol.Cell V. 26 403 2007.
ISSN: ISSN 1097-2765
PubMed: 17499046
DOI: 10.1016/J.MOLCEL.2007.03.017