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Zinc in PDB 2mze: uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7)

Enzymatic activity of uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7)

All present enzymatic activity of uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7):
3.4.24.23;

Other elements in 2mze:

The structure of uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) also contains other interesting chemical elements:

Calcium (Ca) 40 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) (pdb code 2mze). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7), PDB code: 2mze:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 2mze

Go back to Zinc Binding Sites List in 2mze
Zinc binding site 1 out of 2 in the uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn303

b:30.3
occ:1.00
NE2 A:HIS143 2.1 61.1 1.0
OD2 A:ASP145 2.2 70.0 1.0
NE2 A:HIS158 2.2 72.0 1.0
HZ A:PHE160 2.4 51.1 1.0
ND1 A:HIS171 2.4 15.5 1.0
HE1 A:HIS171 2.8 1.3 1.0
CD2 A:HIS158 2.9 24.5 1.0
CE1 A:HIS171 2.9 72.5 1.0
CD2 A:HIS143 3.0 61.0 1.0
HB2 A:ASP145 3.0 22.5 1.0
HD2 A:HIS158 3.0 61.3 1.0
CE1 A:HIS143 3.1 51.4 1.0
CG A:ASP145 3.1 72.1 1.0
CE1 A:HIS158 3.2 55.1 1.0
HD2 A:HIS143 3.2 31.2 1.0
HE1 A:HIS143 3.3 73.5 1.0
CZ A:PHE160 3.4 13.0 1.0
CB A:ASP145 3.4 31.2 1.0
HE1 A:HIS158 3.6 1.1 1.0
HB3 A:ASP145 3.6 41.3 1.0
CG A:HIS171 3.7 32.4 1.0
HE1 A:PHE160 3.9 21.3 1.0
CG A:HIS158 4.0 52.2 1.0
ND1 A:HIS143 4.1 55.4 1.0
CG A:HIS143 4.1 2.3 1.0
CE1 A:PHE160 4.1 63.2 1.0
OD1 A:ASP145 4.1 10.5 1.0
ND1 A:HIS158 4.1 12.2 1.0
HB3 A:HIS171 4.2 34.4 1.0
NE2 A:HIS171 4.2 54.3 1.0
HB2 A:HIS171 4.2 11.4 1.0
CB A:HIS171 4.3 23.1 1.0
CE2 A:PHE160 4.4 62.2 1.0
HE2 A:PHE160 4.4 1.1 1.0
CD2 A:HIS171 4.6 13.1 1.0
CA A:ASP145 4.9 32.1 1.0
HE2 A:HIS171 5.0 34.1 1.0
HD1 A:HIS143 5.0 32.1 1.0

Zinc binding site 2 out of 2 in 2mze

Go back to Zinc Binding Sites List in 2mze
Zinc binding site 2 out of 2 in the uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of uc(Nmr) Solution Structure of the Pro Form of Human Matrilysin (Prommp-7) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn304

b:33.0
occ:1.00
NE2 A:HIS194 2.1 53.2 1.0
NE2 A:HIS204 2.1 1.4 1.0
NE2 A:HIS198 2.1 21.5 1.0
HE1 A:HIS198 2.4 4.4 1.0
CE1 A:HIS198 2.5 75.2 1.0
CE1 A:HIS204 2.6 3.5 1.0
HE1 A:HIS204 2.6 71.4 1.0
HB2 A:CYS67 2.9 53.2 1.0
CD2 A:HIS194 2.9 71.4 1.0
HD2 A:HIS194 3.0 3.3 1.0
HB3 A:CYS67 3.0 4.3 1.0
SG A:CYS67 3.2 55.3 1.0
CB A:CYS67 3.2 51.1 1.0
CE1 A:HIS194 3.2 24.0 1.0
CD2 A:HIS204 3.3 70.1 1.0
CD2 A:HIS198 3.4 10.5 1.0
HG22 A:VAL69 3.5 52.5 1.0
HE1 A:HIS194 3.6 15.4 1.0
HD2 A:HIS204 3.8 63.0 1.0
ND1 A:HIS198 3.8 2.4 1.0
ND1 A:HIS204 3.8 42.4 1.0
HD2 A:HIS198 4.0 34.2 1.0
CG A:HIS194 4.1 35.3 1.0
HG A:CYS67 4.1 65.3 1.0
CG A:HIS204 4.2 11.1 1.0
HE A:ARG66 4.2 33.1 1.0
ND1 A:HIS194 4.2 1.1 1.0
CG A:HIS198 4.3 3.4 1.0
HG23 A:VAL69 4.4 54.3 1.0
CG2 A:VAL69 4.4 22.2 1.0
NE A:ARG66 4.4 31.1 1.0
HG2 A:ARG66 4.4 0.3 1.0
HB A:VAL69 4.4 12.2 1.0
HD2 A:ARG66 4.5 32.2 1.0
HD1 A:HIS198 4.5 4.4 1.0
HD1 A:HIS204 4.6 51.2 1.0
HH21 A:ARG66 4.6 41.3 1.0
CZ A:ARG66 4.7 32.0 1.0
CA A:CYS67 4.7 40.3 1.0
H A:VAL69 4.7 52.4 1.0
HZ A:PHE45 4.8 62.4 1.0
NH2 A:ARG66 4.8 10.4 1.0
O A:VAL69 4.9 50.1 1.0
O A:HIS194 4.9 61.2 1.0
CD A:ARG66 4.9 44.0 1.0
CB A:VAL69 5.0 43.2 1.0

Reference:

S.H.Prior, Y.G.Fulcher, R.K.Koppisetti, A.Jurkevich, S.R.Van Doren. Charge-Triggered Membrane Insertion of Matrix Metalloproteinase-7, Supporter of Innate Immunity and Tumors. Structure V. 23 2099 2015.
ISSN: ISSN 0969-2126
PubMed: 26439767
DOI: 10.1016/J.STR.2015.08.013
Page generated: Wed Dec 16 03:41:25 2020

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