Zinc in PDB 2lv9: Solution uc(Nmr) Structure of the Phd Domain of Human MLL5, Northeast Structural Genomics Consortium Target HR6512A

All present enzymatic activity of Solution uc(Nmr) Structure of the Phd Domain of Human MLL5, Northeast Structural Genomics Consortium Target HR6512A:
2.1.1.43;

The binding sites of Zinc atom in the Solution uc(Nmr) Structure of the Phd Domain of Human MLL5, Northeast Structural Genomics Consortium Target HR6512A (pdb code 2lv9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Solution uc(Nmr) Structure of the Phd Domain of Human MLL5, Northeast Structural Genomics Consortium Target HR6512A, PDB code: 2lv9:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Solution uc(Nmr) Structure of the Phd Domain of Human MLL5, Northeast Structural Genomics Consortium Target HR6512A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution uc(Nmr) Structure of the Phd Domain of Human MLL5, Northeast Structural Genomics Consortium Target HR6512A within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:0.0 occ:1.00 ND1 A:HIS143 2.1 0.0 1.0 SG A:CYS121 2.3 0.0 1.0 SG A:CYS146 2.3 0.0 1.0 SG A:CYS123 2.3 0.0 1.0 HG3 A:GLN177 2.5 0.0 1.0 HB2 A:HIS143 2.8 0.0 1.0 CE1 A:HIS143 3.1 0.0 1.0 CG A:HIS143 3.1 0.0 1.0 H A:HIS143 3.2 0.0 1.0 HE1 A:HIS143 3.3 0.0 1.0 HB3 A:CYS121 3.3 0.0 1.0 HB3 A:CYS123 3.3 0.0 1.0 CB A:HIS143 3.5 0.0 1.0 CB A:CYS121 3.5 0.0 1.0 CB A:CYS123 3.5 0.0 1.0 CG A:GLN177 3.5 0.0 1.0 CB A:CYS146 3.5 0.0 1.0 HB2 A:CYS146 3.6 0.0 1.0 H A:CYS123 3.6 0.0 1.0 HB3 A:CYS146 3.7 0.0 1.0 CD A:GLN177 3.9 0.0 1.0 HB2 A:CYS121 4.0 0.0 1.0 HD11 A:ILE122 4.0 0.0 1.0 N A:HIS143 4.0 0.0 1.0 HG2 A:GLN177 4.1 0.0 1.0 O A:PHE125 4.2 0.0 1.0 NE2 A:HIS143 4.2 0.0 1.0 HB2 A:CYS123 4.2 0.0 1.0 CD2 A:HIS143 4.2 0.0 1.0 OE1 A:GLN177 4.3 0.0 1.0 HB3 A:HIS143 4.3 0.0 1.0 HB3 A:PHE125 4.3 0.0 1.0 CA A:HIS143 4.4 0.0 1.0 NE2 A:GLN177 4.4 0.0 1.0 N A:CYS123 4.4 0.0 1.0 HB2 A:GLN177 4.4 0.0 1.0 CB A:GLN177 4.5 0.0 1.0 HE21 A:GLN177 4.5 0.0 1.0 HB3 A:GLN177 4.5 0.0 1.0 CA A:CYS123 4.6 0.0 1.0 HA A:GLN142 4.6 0.0 1.0 H A:PHE125 4.6 0.0 1.0 CA A:CYS121 4.7 0.0 1.0 HD13 A:ILE122 4.8 0.0 1.0 HB3 A:GLN142 4.8 0.0 1.0 HB3 A:ALA173 4.8 0.0 1.0 CD1 A:ILE122 4.9 0.0 1.0 HD2 A:PHE125 4.9 0.0 1.0 CA A:CYS146 4.9 0.0 1.0 H A:ILE122 4.9 0.0 1.0 HE22 A:GLN177 5.0 0.0 1.0 C A:CYS121 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the Solution uc(Nmr) Structure of the Phd Domain of Human MLL5, Northeast Structural Genomics Consortium Target HR6512A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution uc(Nmr) Structure of the Phd Domain of Human MLL5, Northeast Structural Genomics Consortium Target HR6512A within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:0.0 occ:1.00 SG A:CYS135 2.3 0.0 1.0 SG A:CYS138 2.3 0.0 1.0 SG A:CYS163 2.4 0.0 1.0 SG A:CYS160 2.4 0.0 1.0 H A:CYS160 2.8 0.0 1.0 HG21 A:VAL140 3.2 0.0 1.0 H A:CYS138 3.2 0.0 1.0 HB2 A:CYS163 3.4 0.0 1.0 HB3 A:CYS138 3.5 0.0 1.0 HB3 A:CYS135 3.5 0.0 1.0 CB A:CYS135 3.5 0.0 1.0 CB A:CYS163 3.5 0.0 1.0 CB A:CYS138 3.6 0.0 1.0 CB A:CYS160 3.6 0.0 1.0 HB3 A:CYS160 3.6 0.0 1.0 N A:CYS160 3.7 0.0 1.0 HB3 A:LYS137 3.7 0.0 1.0 HB2 A:CYS135 3.8 0.0 1.0 HG22 A:VAL140 4.0 0.0 1.0 H A:CYS163 4.0 0.0 1.0 CG2 A:VAL140 4.0 0.0 1.0 N A:CYS138 4.0 0.0 1.0 HA A:LEU159 4.1 0.0 1.0 CA A:CYS160 4.2 0.0 1.0 HB3 A:CYS163 4.2 0.0 1.0 CA A:CYS138 4.4 0.0 1.0 HG23 A:VAL140 4.4 0.0 1.0 HB2 A:CYS138 4.4 0.0 1.0 N A:CYS163 4.4 0.0 1.0 H A:VAL140 4.5 0.0 1.0 HB2 A:CYS160 4.5 0.0 1.0 CA A:CYS163 4.6 0.0 1.0 HB2 A:ARG162 4.6 0.0 1.0 O A:CYS160 4.7 0.0 1.0 C A:CYS160 4.8 0.0 1.0 HD2 A:LYS137 4.8 0.0 1.0 C A:LEU159 4.8 0.0 1.0 CB A:LYS137 4.8 0.0 1.0 HD22 A:LEU159 4.9 0.0 1.0 CA A:CYS135 4.9 0.0 1.0 H A:LYS137 4.9 0.0 1.0 CA A:LEU159 4.9 0.0 1.0 HD21 A:LEU159 4.9 0.0 1.0 HG11 A:VAL140 5.0 0.0 1.0 C A:CYS138 5.0 0.0 1.0 HA A:CYS163 5.0 0.0 1.0

A.Lemak, A.Yee, S.Houliston, M.Garcia, H.Wu, J.Min, G.T.Montelione, C.Arrowsmith. uc(Nmr) Solution Structure of the Human MLL5 Phd Domain (Casp Target) To Be Published.