Zinc in PDB 2ka6: uc(Nmr) Structure of the Cbp-TAZ2/STAT1-Tad Complex

All present enzymatic activity of uc(Nmr) Structure of the Cbp-TAZ2/STAT1-Tad Complex:
2.3.1.48;

The binding sites of Zinc atom in the uc(Nmr) Structure of the Cbp-TAZ2/STAT1-Tad Complex (pdb code 2ka6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the uc(Nmr) Structure of the Cbp-TAZ2/STAT1-Tad Complex, PDB code: 2ka6:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the uc(Nmr) Structure of the Cbp-TAZ2/STAT1-Tad Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of uc(Nmr) Structure of the Cbp-TAZ2/STAT1-Tad Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn93 b:0.0 occ:1.00 NE2 A:HIS19 2.1 0.0 1.0 SG A:CYS28 2.3 0.0 1.0 SG A:CYS23 2.3 0.0 1.0 SG A:CYS33 2.3 0.0 1.0 CD2 A:HIS19 2.8 0.0 1.0 HD2 A:HIS19 2.8 0.0 1.0 HZ1 A:LYS37 2.8 0.0 1.0 HZ3 A:LYS37 2.9 0.0 1.0 HB2 A:CYS23 3.0 0.0 1.0 HB2 A:CYS28 3.0 0.0 1.0 CB A:CYS23 3.1 0.0 1.0 CB A:CYS28 3.1 0.0 1.0 HB3 A:CYS28 3.3 0.0 1.0 HD21 A:ASN25 3.3 0.0 1.0 HB3 A:CYS23 3.3 0.0 1.0 CE1 A:HIS19 3.3 0.0 1.0 NZ A:LYS37 3.4 0.0 1.0 CB A:CYS33 3.5 0.0 1.0 HB2 A:CYS33 3.6 0.0 1.0 HB3 A:CYS33 3.8 0.0 1.0 HE1 A:HIS19 3.8 0.0 1.0 HB2 A:ASN25 3.8 0.0 1.0 HZ2 A:LYS37 3.9 0.0 1.0 CG A:HIS19 4.0 0.0 1.0 HD13 A:LEU30 4.1 0.0 1.0 HB2 A:LEU30 4.2 0.0 1.0 ND2 A:ASN25 4.2 0.0 1.0 HE3 A:LYS37 4.3 0.0 1.0 ND1 A:HIS19 4.3 0.0 1.0 HA A:ALA20 4.3 0.0 1.0 CE A:LYS37 4.5 0.0 1.0 CA A:CYS23 4.5 0.0 1.0 CA A:CYS28 4.5 0.0 1.0 H A:ASN25 4.6 0.0 1.0 HA A:CYS23 4.7 0.0 1.0 H A:LEU30 4.7 0.0 1.0 HD22 A:ASN25 4.7 0.0 1.0 HA A:CYS28 4.7 0.0 1.0 CB A:ASN25 4.8 0.0 1.0 CA A:CYS33 4.9 0.0 1.0 CG A:ASN25 5.0 0.0 1.0

Zinc binding site 2 out of 3 in the uc(Nmr) Structure of the Cbp-TAZ2/STAT1-Tad Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of uc(Nmr) Structure of the Cbp-TAZ2/STAT1-Tad Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn94 b:0.0 occ:1.00 NE2 A:HIS42 2.1 0.0 1.0 SG A:CYS54 2.3 0.0 1.0 SG A:CYS57 2.3 0.0 1.0 SG A:CYS46 2.3 0.0 1.0 HE1 A:HIS42 2.7 0.0 1.0 CE1 A:HIS42 2.7 0.0 1.0 HZ2 A:LYS49 2.9 0.0 1.0 HH21 A:ARG48 2.9 0.0 1.0 H A:CYS57 3.0 0.0 1.0 HB2 A:CYS46 3.0 0.0 1.0 CB A:CYS46 3.1 0.0 1.0 HB3 A:CYS46 3.3 0.0 1.0 H A:LYS49 3.3 0.0 1.0 HE A:ARG48 3.3 0.0 1.0 CD2 A:HIS42 3.3 0.0 1.0 HZ1 A:LYS49 3.4 0.0 1.0 HB A:VAL56 3.5 0.0 1.0 CB A:CYS54 3.5 0.0 1.0 HB2 A:ARG48 3.6 0.0 1.0 HB2 A:CYS54 3.6 0.0 1.0 CB A:CYS57 3.6 0.0 1.0 NZ A:LYS49 3.7 0.0 1.0 HB3 A:CYS54 3.7 0.0 1.0 HB2 A:CYS57 3.7 0.0 1.0 HA A:THR43 3.8 0.0 1.0 NH2 A:ARG48 3.8 0.0 1.0 HD2 A:HIS42 3.8 0.0 1.0 N A:CYS57 3.8 0.0 1.0 HG1 A:THR43 3.9 0.0 1.0 HA A:LYS49 4.0 0.0 1.0 ND1 A:HIS42 4.0 0.0 1.0 HZ3 A:LYS49 4.1 0.0 1.0 NE A:ARG48 4.2 0.0 1.0 H A:ARG48 4.2 0.0 1.0 N A:LYS49 4.2 0.0 1.0 CA A:CYS57 4.3 0.0 1.0 CG A:HIS42 4.3 0.0 1.0 CZ A:ARG48 4.4 0.0 1.0 HH22 A:ARG48 4.4 0.0 1.0 HB3 A:CYS57 4.5 0.0 1.0 HA A:CYS57 4.5 0.0 1.0 CB A:VAL56 4.5 0.0 1.0 CA A:CYS46 4.5 0.0 1.0 H A:VAL56 4.6 0.0 1.0 CB A:ARG48 4.6 0.0 1.0 CA A:LYS49 4.7 0.0 1.0 HE2 A:LYS49 4.7 0.0 1.0 OG1 A:THR43 4.7 0.0 1.0 CA A:THR43 4.8 0.0 1.0 HA A:CYS46 4.8 0.0 1.0 CE A:LYS49 4.8 0.0 1.0 CA A:CYS54 4.8 0.0 1.0 HD1 A:HIS42 4.8 0.0 1.0 C A:VAL56 4.8 0.0 1.0 H A:LYS47 4.8 0.0 1.0 HA A:CYS54 4.9 0.0 1.0 HB3 A:LYS49 5.0 0.0 1.0

Zinc binding site 3 out of 3 in the uc(Nmr) Structure of the Cbp-TAZ2/STAT1-Tad Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of uc(Nmr) Structure of the Cbp-TAZ2/STAT1-Tad Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn95 b:0.0 occ:1.00 NE2 A:HIS67 2.1 0.0 1.0 SG A:CYS81 2.3 0.0 1.0 SG A:CYS76 2.3 0.0 1.0 SG A:CYS71 2.3 0.0 1.0 HZ3 A:LYS85 2.5 0.0 1.0 CD2 A:HIS67 2.9 0.0 1.0 HB2 A:CYS71 2.9 0.0 1.0 HD2 A:HIS67 3.0 0.0 1.0 CB A:CYS71 3.0 0.0 1.0 HZ2 A:LYS85 3.0 0.0 1.0 HB3 A:CYS71 3.2 0.0 1.0 CE1 A:HIS67 3.2 0.0 1.0 NZ A:LYS85 3.3 0.0 1.0 CB A:CYS76 3.4 0.0 1.0 HB2 A:CYS76 3.5 0.0 1.0 HE1 A:HIS67 3.6 0.0 1.0 HB3 A:CYS76 3.6 0.0 1.0 CB A:CYS81 3.7 0.0 1.0 HB2 A:CYS81 3.9 0.0 1.0 HZ1 A:LYS85 3.9 0.0 1.0 HB3 A:CYS81 3.9 0.0 1.0 CG A:HIS67 4.1 0.0 1.0 HE2 A:LYS85 4.1 0.0 1.0 ND1 A:HIS67 4.3 0.0 1.0 HA A:ALA68 4.3 0.0 1.0 CE A:LYS85 4.3 0.0 1.0 CA A:CYS71 4.4 0.0 1.0 HA A:CYS71 4.6 0.0 1.0 HB A:VAL78 4.6 0.0 1.0 HB3 A:GLU73 4.7 0.0 1.0 HE3 A:LYS85 4.7 0.0 1.0 CA A:CYS76 4.8 0.0 1.0 H A:GLU73 4.8 0.0 1.0 HA A:CYS76 4.9 0.0 1.0 HD2 A:PRO77 4.9 0.0 1.0 CA A:CYS81 4.9 0.0 1.0

J.M.Wojciak, M.A.Martinez-Yamout, H.J.Dyson, P.E.Wright. Structural Basis For Recruitment of Cbp/P300 Coactivators By STAT1 and STAT2 Transactivation Domains. Embo J. V. 28 948 2009.
ISSN: ISSN 0261-4189
PubMed: 19214187
DOI: 10.1038/EMBOJ.2009.30