Atomistry » Zinc » PDB 2ivh-2jaz » 2j1z
Atomistry »
  Zinc »
    PDB 2ivh-2jaz »
      2j1z »

Zinc in PDB 2j1z: Human P53 Core Domain Mutant M133L-V203A-N239Y-N268D-F270L

Protein crystallography data

The structure of Human P53 Core Domain Mutant M133L-V203A-N239Y-N268D-F270L, PDB code: 2j1z was solved by A.C.Joerger, A.R.Fersht, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.1 / 1.8
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 64.708, 71.035, 104.923, 90.00, 90.00, 90.00
R / Rfree (%) 18.4 / 21.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Human P53 Core Domain Mutant M133L-V203A-N239Y-N268D-F270L (pdb code 2j1z). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human P53 Core Domain Mutant M133L-V203A-N239Y-N268D-F270L, PDB code: 2j1z:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 2j1z

Go back to Zinc Binding Sites List in 2j1z
Zinc binding site 1 out of 2 in the Human P53 Core Domain Mutant M133L-V203A-N239Y-N268D-F270L


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human P53 Core Domain Mutant M133L-V203A-N239Y-N268D-F270L within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1291

b:26.8
occ:1.00
ND1 A:HIS179 2.0 11.5 1.0
SG A:CYS242 2.3 16.8 1.0
SG A:CYS238 2.4 18.6 1.0
SG A:CYS176 2.4 13.6 1.0
CE1 A:HIS179 3.0 16.4 1.0
CB A:CYS242 3.1 18.2 1.0
CG A:HIS179 3.1 13.5 1.0
CB A:CYS238 3.5 19.8 1.0
CB A:CYS176 3.5 12.9 1.0
CB A:HIS179 3.5 14.4 1.0
CA A:CYS238 3.8 15.3 1.0
O A:HOH2110 3.9 35.8 1.0
N A:CYS176 4.0 12.7 1.0
NE2 A:HIS179 4.1 15.0 1.0
CD2 A:HIS179 4.2 14.6 1.0
N A:TYR239 4.3 12.8 1.0
N A:HIS179 4.3 14.4 1.0
CA A:CYS176 4.3 13.3 1.0
CA A:CYS242 4.5 17.4 1.0
CA A:HIS179 4.5 14.0 1.0
C A:CYS238 4.6 14.6 1.0
O A:MET237 4.7 11.6 1.0
O A:HOH2096 4.7 19.0 1.0

Zinc binding site 2 out of 2 in 2j1z

Go back to Zinc Binding Sites List in 2j1z
Zinc binding site 2 out of 2 in the Human P53 Core Domain Mutant M133L-V203A-N239Y-N268D-F270L


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human P53 Core Domain Mutant M133L-V203A-N239Y-N268D-F270L within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1291

b:28.4
occ:1.00
ND1 B:HIS179 2.0 14.6 1.0
SG B:CYS242 2.3 16.7 1.0
SG B:CYS176 2.4 13.6 1.0
SG B:CYS238 2.4 15.6 1.0
CE1 B:HIS179 3.0 16.5 1.0
CG B:HIS179 3.1 13.3 1.0
CB B:CYS242 3.1 17.6 1.0
CB B:HIS179 3.4 13.3 1.0
CB B:CYS238 3.4 16.9 1.0
CB B:CYS176 3.5 14.7 1.0
CA B:CYS238 3.8 12.9 1.0
O B:HOH2094 4.0 37.5 1.0
N B:CYS176 4.1 11.8 1.0
NE2 B:HIS179 4.1 14.9 1.0
CD2 B:HIS179 4.2 15.2 1.0
N B:HIS179 4.4 13.6 1.0
CA B:CYS176 4.4 13.3 1.0
N B:TYR239 4.4 14.1 1.0
CA B:CYS242 4.5 17.8 1.0
CA B:HIS179 4.5 13.8 1.0
O B:MET237 4.6 13.0 1.0
C B:CYS238 4.6 12.6 1.0
O B:HOH2083 4.7 18.2 1.0
N B:CYS238 5.0 12.5 1.0

Reference:

A.C.Joerger, H.C.Ang, A.R.Fersht. Structural Basis For Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.Usa V. 103 15056 2006.
ISSN: ISSN 0027-8424
PubMed: 17015838
DOI: 10.1073/PNAS.0607286103
Page generated: Thu Oct 17 01:05:05 2024

Last articles

Al in 1N2C
Al in 1QF9
Al in 1OH9
Al in 1L7N
Al in 1N6K
Al in 1MND
Al in 1K5G
Al in 1KDN
Al in 1L3R
Al in 1KHJ
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy