Zinc in PDB 2j1w: Human P53 Core Domain Mutant M133L-V143A-V203A-N239Y-N268D

The structure of Human P53 Core Domain Mutant M133L-V143A-V203A-N239Y-N268D, PDB code: 2j1w was solved by A.C.Joerger, A.R.Fersht, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.4 / 1.8
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	64.656, 71.066, 105.001, 90.00, 90.00, 90.00
R / Rfree (%)	18.5 / 20.6

The binding sites of Zinc atom in the Human P53 Core Domain Mutant M133L-V143A-V203A-N239Y-N268D (pdb code 2j1w). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human P53 Core Domain Mutant M133L-V143A-V203A-N239Y-N268D, PDB code: 2j1w:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human P53 Core Domain Mutant M133L-V143A-V203A-N239Y-N268D


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human P53 Core Domain Mutant M133L-V143A-V203A-N239Y-N268D within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn313 b:18.3 occ:1.00 ND1 A:HIS179 2.0 11.4 1.0 SG A:CYS242 2.3 16.5 1.0 SG A:CYS238 2.4 18.8 1.0 SG A:CYS176 2.4 15.3 1.0 CE1 A:HIS179 2.9 15.5 1.0 CG A:HIS179 3.0 15.3 1.0 CB A:CYS242 3.1 18.1 1.0 CB A:CYS238 3.4 20.1 1.0 CB A:HIS179 3.4 15.5 1.0 CB A:CYS176 3.5 13.1 1.0 CA A:CYS238 3.8 16.1 1.0 O A:HOH2103 4.0 40.6 1.0 N A:CYS176 4.0 13.5 1.0 NE2 A:HIS179 4.1 15.2 1.0 CD2 A:HIS179 4.1 14.4 1.0 N A:HIS179 4.3 16.4 1.0 N A:TYR239 4.3 14.7 1.0 CA A:CYS176 4.3 14.3 1.0 CA A:HIS179 4.5 14.4 1.0 CA A:CYS242 4.5 18.6 1.0 C A:CYS238 4.6 16.1 1.0 O A:HOH2089 4.6 21.2 1.0 O A:MET237 4.7 13.5 1.0

Zinc binding site 2 out of 2 in the Human P53 Core Domain Mutant M133L-V143A-V203A-N239Y-N268D


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human P53 Core Domain Mutant M133L-V143A-V203A-N239Y-N268D within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn313 b:18.6 occ:1.00 ND1 B:HIS179 2.0 15.5 1.0 SG B:CYS242 2.3 16.4 1.0 SG B:CYS238 2.4 15.2 1.0 SG B:CYS176 2.4 14.7 1.0 CE1 B:HIS179 3.0 16.2 1.0 CG B:HIS179 3.0 16.6 1.0 CB B:CYS242 3.1 16.3 1.0 CB B:CYS238 3.4 15.8 1.0 CB B:HIS179 3.4 15.3 1.0 CB B:CYS176 3.4 14.3 1.0 CA B:CYS238 3.8 14.4 1.0 O B:HOH2102 3.9 39.2 1.0 N B:CYS176 4.0 12.0 1.0 NE2 B:HIS179 4.1 17.2 1.0 CD2 B:HIS179 4.1 16.6 1.0 N B:HIS179 4.3 14.7 1.0 CA B:CYS176 4.3 15.0 1.0 N B:TYR239 4.4 13.9 1.0 CA B:HIS179 4.5 14.3 1.0 CA B:CYS242 4.5 20.2 1.0 O B:HOH2090 4.6 22.6 1.0 C B:CYS238 4.6 12.9 1.0 O B:MET237 4.7 15.2 1.0

A.C.Joerger, H.C.Ang, A.R.Fersht. Structural Basis For Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.Usa V. 103 15056 2006.
ISSN: ISSN 0027-8424
PubMed: 17015838
DOI: 10.1073/PNAS.0607286103