Zinc in PDB 2ics: Crystal Structure of An Adenine Deaminase

All present enzymatic activity of Crystal Structure of An Adenine Deaminase:
3.5.4.2;

The structure of Crystal Structure of An Adenine Deaminase, PDB code: 2ics was solved by R.Sugadev, D.Kumaran, S.K.Burley, S.Swaminathan, New York Sgxresearch Center For Structural Genomics (Nysgxrc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.82 / 2.30
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	62.373, 141.686, 47.396, 90.00, 90.00, 90.00
R / Rfree (%)	19.8 / 23.9

The binding sites of Zinc atom in the Crystal Structure of An Adenine Deaminase (pdb code 2ics). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of An Adenine Deaminase, PDB code: 2ics:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of An Adenine Deaminase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of An Adenine Deaminase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn400 b:24.9 occ:1.00 OQ1 A:KCX154 1.9 27.5 1.0 NE2 A:HIS62 2.0 25.6 1.0 O A:HOH1115 2.0 23.2 1.0 OD1 A:ASP272 2.2 19.4 1.0 NE2 A:HIS60 2.2 14.4 1.0 CD2 A:HIS62 2.9 22.1 1.0 CX A:KCX154 3.0 30.1 1.0 CE1 A:HIS62 3.1 24.4 1.0 CG A:ASP272 3.1 21.9 1.0 CE1 A:HIS60 3.2 16.1 1.0 CD2 A:HIS60 3.3 13.9 1.0 OH A:TYR70 3.3 52.2 1.0 OQ2 A:KCX154 3.5 31.9 1.0 ZN A:ZN401 3.6 30.1 1.0 OD2 A:ASP272 3.7 26.8 1.0 CE2 A:TYR70 3.8 50.9 1.0 CZ A:TYR70 4.0 50.7 1.0 CG A:HIS62 4.1 24.5 1.0 NZ A:KCX154 4.2 26.6 1.0 ND1 A:HIS62 4.2 23.1 1.0 CB A:ASP272 4.2 17.3 1.0 ND1 A:HIS60 4.4 16.2 1.0 N6 A:ADE1114 4.4 75.9 1.0 CG A:HIS60 4.4 14.4 1.0 CB A:ALA89 4.5 20.1 1.0 CA A:ASP272 4.6 18.4 1.0 CE1 A:HIS211 4.6 22.1 1.0 NE2 A:HIS211 4.7 21.9 1.0 CE A:KCX154 4.8 23.9 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of An Adenine Deaminase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of An Adenine Deaminase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:30.1 occ:1.00 ND1 A:HIS188 2.1 18.5 1.0 OQ2 A:KCX154 2.2 31.9 1.0 NE2 A:HIS211 2.2 21.9 1.0 O A:HOH1115 2.2 23.2 1.0 N6 A:ADE1114 2.4 75.9 1.0 CX A:KCX154 2.9 30.1 1.0 CE1 A:HIS188 3.0 18.4 1.0 OQ1 A:KCX154 3.1 27.5 1.0 CE1 A:HIS211 3.1 22.1 1.0 CG A:HIS188 3.2 19.9 1.0 CD2 A:HIS211 3.2 18.4 1.0 ZN A:ZN400 3.6 24.9 1.0 CB A:HIS188 3.7 20.6 1.0 C6 A:ADE1114 3.7 78.3 1.0 CE1 A:HIS60 4.1 16.1 1.0 NZ A:KCX154 4.1 26.6 1.0 CD A:ARG156 4.1 25.3 1.0 NE2 A:HIS188 4.2 20.6 1.0 ND1 A:HIS211 4.3 19.8 1.0 NE2 A:HIS60 4.3 14.4 1.0 O A:HOH1157 4.3 32.1 1.0 CD2 A:HIS188 4.3 16.7 1.0 CG A:HIS211 4.4 21.1 1.0 OD2 A:ASP272 4.4 26.8 1.0 N1 A:ADE1114 4.6 78.4 1.0 C5 A:ADE1114 4.6 79.8 1.0 OH A:TYR70 4.6 52.2 1.0 CE A:KCX154 4.6 23.9 1.0 CG A:ARG156 4.7 24.2 1.0 OD1 A:ASP272 4.8 19.4 1.0 N7 A:ADE1114 4.8 80.6 1.0 CG A:ASP272 4.8 21.9 1.0 CA A:HIS188 4.9 21.4 1.0 NH1 A:ARG156 4.9 28.0 1.0

R.Sugadev, D.Kumaran, S.K.Burley, S.Swaminathan. Crystal Structure of An Adenine Deaminase To Be Published.