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Atomistry » Zinc » PDB 2hpy-2i7v » 2hx3 » |
Zinc in PDB 2hx3: Rat Nnos Heme Domain Complexed with (4S)-N-{4-Amino-5-[(2-Aminoethyl)- Hydroxyamino]-Pentyl}-N'-NitroguanidineEnzymatic activity of Rat Nnos Heme Domain Complexed with (4S)-N-{4-Amino-5-[(2-Aminoethyl)- Hydroxyamino]-Pentyl}-N'-Nitroguanidine
All present enzymatic activity of Rat Nnos Heme Domain Complexed with (4S)-N-{4-Amino-5-[(2-Aminoethyl)- Hydroxyamino]-Pentyl}-N'-Nitroguanidine:
1.14.13.39; Protein crystallography data
The structure of Rat Nnos Heme Domain Complexed with (4S)-N-{4-Amino-5-[(2-Aminoethyl)- Hydroxyamino]-Pentyl}-N'-Nitroguanidine, PDB code: 2hx3
was solved by
J.Igarashi,
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2hx3:
The structure of Rat Nnos Heme Domain Complexed with (4S)-N-{4-Amino-5-[(2-Aminoethyl)- Hydroxyamino]-Pentyl}-N'-Nitroguanidine also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Rat Nnos Heme Domain Complexed with (4S)-N-{4-Amino-5-[(2-Aminoethyl)- Hydroxyamino]-Pentyl}-N'-Nitroguanidine
(pdb code 2hx3). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Rat Nnos Heme Domain Complexed with (4S)-N-{4-Amino-5-[(2-Aminoethyl)- Hydroxyamino]-Pentyl}-N'-Nitroguanidine, PDB code: 2hx3: Zinc binding site 1 out of 1 in 2hx3Go back to Zinc Binding Sites List in 2hx3
Zinc binding site 1 out
of 1 in the Rat Nnos Heme Domain Complexed with (4S)-N-{4-Amino-5-[(2-Aminoethyl)- Hydroxyamino]-Pentyl}-N'-Nitroguanidine
Mono view Stereo pair view
Reference:
J.Seo,
J.Igarashi,
H.Li,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
Structure-Based Design and Synthesis of N(Omega)-Nitro-L-Arginine-Containing Peptidomimetics As Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem. V. 50 2089 2007.
Page generated: Thu Oct 17 00:44:30 2024
ISSN: ISSN 0022-2623 PubMed: 17425297 DOI: 10.1021/JM061305C |
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