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Zinc in PDB 2hfz: Crystal Structure of Rna Dependent Rna Polymerase Domain From West Nile Virus

Enzymatic activity of Crystal Structure of Rna Dependent Rna Polymerase Domain From West Nile Virus

All present enzymatic activity of Crystal Structure of Rna Dependent Rna Polymerase Domain From West Nile Virus:
2.7.7.48;

Protein crystallography data

The structure of Crystal Structure of Rna Dependent Rna Polymerase Domain From West Nile Virus, PDB code: 2hfz was solved by M.P.Egloff, H.Malet, Marseilles Structural Genomics Program @Afmb (Msgp), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 95.35 / 3.00
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 73.333, 103.449, 190.074, 90.00, 90.00, 90.00
R / Rfree (%) 26 / 26.5

Other elements in 2hfz:

The structure of Crystal Structure of Rna Dependent Rna Polymerase Domain From West Nile Virus also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Rna Dependent Rna Polymerase Domain From West Nile Virus (pdb code 2hfz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Rna Dependent Rna Polymerase Domain From West Nile Virus, PDB code: 2hfz:

Zinc binding site 1 out of 1 in 2hfz

Go back to Zinc Binding Sites List in 2hfz
Zinc binding site 1 out of 1 in the Crystal Structure of Rna Dependent Rna Polymerase Domain From West Nile Virus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Rna Dependent Rna Polymerase Domain From West Nile Virus within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn907

b:77.1
occ:1.00
OE2 A:GLU440 2.2 85.4 1.0
NE2 A:HIS444 2.2 86.7 1.0
SG A:CYS449 2.4 83.8 1.0
SG A:CYS452 2.4 87.2 1.0
CD2 A:HIS444 3.1 86.7 1.0
CD A:GLU440 3.2 85.4 1.0
CE1 A:HIS444 3.3 86.7 1.0
CG A:GLU440 3.4 85.4 1.0
CB A:CYS449 3.6 83.8 1.0
CB A:CYS452 3.7 87.2 1.0
CA A:CYS449 3.9 84.0 1.0
N A:HIS450 4.2 84.9 1.0
CG A:HIS444 4.3 86.7 1.0
CD1 A:LEU486 4.3 72.5 1.0
OE1 A:GLU440 4.3 85.4 1.0
ND1 A:HIS444 4.4 86.7 1.0
N A:CYS452 4.4 87.0 1.0
OG1 A:THR574 4.5 94.8 1.0
C A:CYS449 4.5 84.0 1.0
CA A:CYS452 4.7 87.0 1.0
O A:GLU448 4.7 85.6 1.0
N A:THR451 4.8 85.8 1.0
CB A:GLU440 4.9 85.4 1.0
O A:GLU440 4.9 84.5 1.0

Reference:

H.Malet, M.P.Egloff, B.Selisko, R.E.Butcher, P.J.Wright, M.Roberts, A.Gruez, G.Sulzenbacher, C.Vonrhein, G.Bricogne, J.M.Mackenzie, A.A.Khromykh, A.D.Davidson, B.Canard. Crystal Structure of the Rna Polymerase Domain of the West Nile Virus Non-Structural Protein 5 J.Biol.Chem. V. 282 10678 2007.
ISSN: ISSN 0021-9258
PubMed: 17287213
DOI: 10.1074/JBC.M607273200
Page generated: Wed Dec 16 03:30:09 2020

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