Zinc in PDB 2h4f: SIR2-P53 Peptide-Nad+

The structure of SIR2-P53 Peptide-Nad+, PDB code: 2h4f was solved by K.G.Hoff, J.L.Avalos, K.Sens, C.Wolberger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	45.821, 59.331, 106.660, 90.00, 90.00, 90.00
R / Rfree (%)	19.2 / 22.8

The binding sites of Zinc atom in the SIR2-P53 Peptide-Nad+ (pdb code 2h4f). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the SIR2-P53 Peptide-Nad+, PDB code: 2h4f:

Zinc binding site 1 out of 1 in the SIR2-P53 Peptide-Nad+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of SIR2-P53 Peptide-Nad+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:35.3 occ:1.00 SG A:CYS127 2.1 35.9 1.0 SG A:CYS148 2.3 38.7 1.0 SG A:CYS124 2.4 28.6 1.0 SG A:CYS151 2.4 40.5 1.0 CB A:CYS124 3.0 27.8 1.0 CB A:CYS148 3.1 38.5 1.0 CB A:CYS127 3.4 34.0 1.0 CB A:CYS151 3.6 42.0 1.0 N A:CYS127 3.8 33.7 1.0 N A:CYS151 4.0 43.1 1.0 CA A:CYS127 4.1 34.5 1.0 CA A:CYS151 4.3 41.6 1.0 CA A:CYS124 4.5 27.3 1.0 CB A:ASP150 4.5 43.6 1.0 CA A:CYS148 4.6 39.1 1.0 CB A:LYS129 4.7 32.2 1.0 C A:CYS127 4.8 34.4 1.0 C A:CYS151 4.8 41.4 1.0 C A:ASP150 4.8 44.0 1.0 N A:GLU128 4.9 34.6 1.0 CB A:SER153 4.9 35.6 1.0 CB A:ARG126 4.9 33.1 1.0 N A:SER153 4.9 37.0 1.0 N A:ASP150 4.9 43.7 1.0 C A:ARG126 5.0 33.1 1.0 N A:ASN152 5.0 40.4 1.0 CA A:ASP150 5.0 43.8 1.0

K.G.Hoff, J.L.Avalos, K.Sens, C.Wolberger. Insights Into the Sirtuin Mechanism From Ternary Complexes Containing Nad(+) and Acetylated Peptide. Structure V. 14 1231 2006.
ISSN: ISSN 0969-2126
PubMed: 16905097
DOI: 10.1016/J.STR.2006.06.006