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Zinc in PDB 2gzl: Structure of 2C-Methyl-D-Erythritol 2,4-Clycodiphosphate Synthase Complexed with A Cdp Derived Fluorescent Inhibitor

Enzymatic activity of Structure of 2C-Methyl-D-Erythritol 2,4-Clycodiphosphate Synthase Complexed with A Cdp Derived Fluorescent Inhibitor

All present enzymatic activity of Structure of 2C-Methyl-D-Erythritol 2,4-Clycodiphosphate Synthase Complexed with A Cdp Derived Fluorescent Inhibitor:
4.6.1.12;

Protein crystallography data

The structure of Structure of 2C-Methyl-D-Erythritol 2,4-Clycodiphosphate Synthase Complexed with A Cdp Derived Fluorescent Inhibitor, PDB code: 2gzl was solved by C.M.Crane, J.Kaiser, N.L.Ramsden, S.Lauw, F.Rohdich, E.Wolfgang, W.N.Hunter, A.Bacher, F.Diederich, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.50
Space group I 21 3
Cell size a, b, c (Å), α, β, γ (°) 145.098, 145.098, 145.098, 90.00, 90.00, 90.00
R / Rfree (%) 20.7 / 23.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of 2C-Methyl-D-Erythritol 2,4-Clycodiphosphate Synthase Complexed with A Cdp Derived Fluorescent Inhibitor (pdb code 2gzl). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of 2C-Methyl-D-Erythritol 2,4-Clycodiphosphate Synthase Complexed with A Cdp Derived Fluorescent Inhibitor, PDB code: 2gzl:

Zinc binding site 1 out of 1 in 2gzl

Go back to Zinc Binding Sites List in 2gzl
Zinc binding site 1 out of 1 in the Structure of 2C-Methyl-D-Erythritol 2,4-Clycodiphosphate Synthase Complexed with A Cdp Derived Fluorescent Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of 2C-Methyl-D-Erythritol 2,4-Clycodiphosphate Synthase Complexed with A Cdp Derived Fluorescent Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn900

b:60.4
occ:1.00
 ND1 A:HIS42 2.0 43.7 1.0
NE2 A:HIS10 2.1 53.4 1.0
OD2 A:ASP8 2.1 44.9 1.0
O1' A:2AA901 2.2 98.3 1.0
CE1 A:HIS10 2.9 53.3 1.0
CE1 A:HIS42 2.9 44.6 1.0
CG A:ASP8 3.0 44.7 1.0
CG A:HIS42 3.1 43.2 1.0
OD1 A:ASP8 3.2 45.9 1.0
CD2 A:HIS10 3.2 51.7 1.0
P2 A:2AA901 3.5 99.0 1.0
CB A:HIS42 3.6 42.1 1.0
O9 A:2AA901 4.0 99.8 1.0
C9 A:2AA901 4.0 1.0 1.0
ND1 A:HIS10 4.0 52.8 1.0
NE2 A:HIS42 4.1 44.8 1.0
CD2 A:HIS42 4.2 44.0 1.0
O2' A:2AA901 4.2 0.6 1.0
CG A:HIS10 4.2 50.6 1.0
C1' A:2AA901 4.3 0.7 1.0
CB A:ASP8 4.4 44.7 1.0
O A:ASP38 4.6 46.7 1.0
O8 A:2AA901 4.7 92.6 1.0
O A:VAL9 4.8 47.1 1.0
O A:HOH945 4.8 85.5 1.0
CA A:VAL39 4.9 45.8 1.0
OG A:SER35 4.9 67.4 1.0
CG1 A:VAL39 5.0 47.2 1.0

Reference:

C.M.Crane, J.Kaiser, N.L.Ramsden, S.Lauw, F.Rohdich, W.Eisenreich, W.N.Hunter, A.Bacher, F.Diederich. Fluorescent Inhibitors For Ispf, An Enzyme in the Non-Mevalonate Pathway For Isoprenoid Biosynthesis and A Potential Target For Antimalarial Therapy. Angew.Chem.Int.Ed.Engl. V. 45 1069 2006.
ISSN: ISSN 1433-7851
PubMed: 16392111
DOI: 10.1002/ANIE.200503003
Page generated: Thu Oct 17 00:27:27 2024

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