Zinc in PDB 2fu8: Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex)

All present enzymatic activity of Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex):
3.5.2.6;

The structure of Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex), PDB code: 2fu8 was solved by L.Nauton, G.Garau, R.Kahn, O.Dideberg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	21.20 / 1.80
Space group	P 62 2 2
Cell size a, b, c (Å), α, β, γ (°)	105.011, 105.011, 196.615, 90.00, 90.00, 120.00
R / Rfree (%)	16 / 18.3

The binding sites of Zinc atom in the Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex) (pdb code 2fu8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex), PDB code: 2fu8:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:14.4 occ:1.00 NE2 A:HIS196 2.1 10.4 1.0 ND1 A:HIS118 2.1 11.6 1.0 NE2 A:HIS116 2.1 9.2 1.0 S A:MCO1410 2.3 16.1 1.0 CD2 A:HIS196 2.9 11.6 1.0 CD2 A:HIS116 3.0 9.6 1.0 CE1 A:HIS118 3.0 11.4 1.0 CE1 A:HIS116 3.1 8.5 1.0 CG A:HIS118 3.1 10.7 1.0 C1 A:MCO1410 3.1 24.1 1.0 CE1 A:HIS196 3.2 13.2 1.0 CB A:HIS118 3.5 10.6 1.0 ZN A:ZN402 3.8 14.2 1.0 CG A:HIS196 4.1 11.8 1.0 CG A:HIS116 4.1 9.2 1.0 NE2 A:HIS118 4.1 10.7 1.0 ND1 A:HIS116 4.2 9.9 1.0 ND1 A:HIS196 4.2 10.4 1.0 CD2 A:HIS118 4.2 12.0 1.0 CD2 A:HIS121 4.2 8.5 1.0 OD1 A:ASP120 4.3 12.7 1.0 NE2 A:HIS121 4.4 9.6 1.0 C2 A:MCO1410 4.6 26.8 1.0 O A:HOH1496 4.8 18.4 1.0 OG A:SER221 4.8 13.9 1.0 CA A:HIS118 5.0 10.5 1.0

Zinc binding site 2 out of 4 in the Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:14.2 occ:1.00 OD2 A:ASP120 2.0 11.7 1.0 NE2 A:HIS121 2.1 9.6 1.0 NE2 A:HIS263 2.1 11.3 1.0 S A:MCO1410 2.2 16.1 1.0 CG A:ASP120 2.8 11.4 1.0 OD1 A:ASP120 2.9 12.7 1.0 CE1 A:HIS121 3.0 9.5 1.0 CE1 A:HIS263 3.0 13.2 1.0 CD2 A:HIS121 3.0 8.5 1.0 CD2 A:HIS263 3.1 13.1 1.0 C1 A:MCO1410 3.4 24.1 1.0 ZN A:ZN401 3.8 14.4 1.0 C2 A:MCO1410 3.9 26.8 1.0 ND1 A:HIS121 4.1 10.5 1.0 C5 A:MCO1410 4.1 30.1 1.0 CG A:HIS121 4.1 11.3 1.0 CB A:ASP120 4.1 11.2 1.0 ND1 A:HIS263 4.1 10.8 1.0 CG A:HIS263 4.2 12.3 1.0 O A:HOH1496 4.2 18.4 1.0 NE2 A:HIS116 4.3 9.2 1.0 CE1 A:HIS116 4.4 8.5 1.0 C4 A:MCO1410 4.6 28.9 1.0 N A:MCO1410 4.7 29.4 1.0 OG A:SER221 4.9 13.9 1.0

Zinc binding site 3 out of 4 in the Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex) within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:15.7 occ:1.00 NE2 B:HIS116 2.0 10.9 1.0 ND1 B:HIS118 2.1 11.6 1.0 NE2 B:HIS196 2.1 12.0 1.0 S B:MCO2410 2.3 20.6 1.0 CD2 B:HIS196 2.9 12.3 1.0 CD2 B:HIS116 2.9 11.6 1.0 CE1 B:HIS118 3.0 13.0 1.0 CE1 B:HIS116 3.0 10.8 1.0 CG B:HIS118 3.1 13.8 1.0 C1 B:MCO2410 3.2 32.9 1.0 CE1 B:HIS196 3.2 14.5 1.0 CB B:HIS118 3.5 11.2 1.0 ZN B:ZN402 3.8 15.4 1.0 ND1 B:HIS116 4.1 10.9 1.0 CG B:HIS116 4.1 11.0 1.0 CG B:HIS196 4.1 13.0 1.0 NE2 B:HIS118 4.1 11.7 1.0 CD2 B:HIS118 4.2 11.9 1.0 ND1 B:HIS196 4.2 13.5 1.0 OD1 B:ASP120 4.2 11.4 1.0 CD2 B:HIS121 4.2 12.1 1.0 NE2 B:HIS121 4.3 11.4 1.0 C2 B:MCO2410 4.6 36.8 1.0 O B:HOH2531 4.8 22.2 1.0 OG B:SER221 4.9 15.2 1.0 CA B:HIS118 4.9 11.6 1.0 CG2 B:THR197 5.0 10.9 1.0

Zinc binding site 4 out of 4 in the Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Zinc-Beta-Lactamase L1 From Stenotrophomonas Maltophilia (D-Captopril Complex) within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn402 b:15.4 occ:1.00 OD2 B:ASP120 1.9 12.1 1.0 NE2 B:HIS121 2.0 11.4 1.0 NE2 B:HIS263 2.1 12.0 1.0 S B:MCO2410 2.3 20.6 1.0 CG B:ASP120 2.7 15.2 1.0 OD1 B:ASP120 2.9 11.4 1.0 CE1 B:HIS121 2.9 13.8 1.0 CE1 B:HIS263 3.0 13.9 1.0 CD2 B:HIS121 3.0 12.1 1.0 CD2 B:HIS263 3.1 13.4 1.0 C1 B:MCO2410 3.5 32.9 1.0 ZN B:ZN401 3.8 15.7 1.0 C5 B:MCO2410 4.0 41.6 1.0 ND1 B:HIS121 4.0 10.3 1.0 C2 B:MCO2410 4.1 36.8 1.0 CG B:HIS121 4.1 12.4 1.0 CB B:ASP120 4.1 12.9 1.0 ND1 B:HIS263 4.1 12.3 1.0 CG B:HIS263 4.2 13.7 1.0 NE2 B:HIS116 4.2 10.9 1.0 CE1 B:HIS116 4.3 10.8 1.0 O B:HOH2531 4.4 22.2 1.0 N B:MCO2410 4.7 41.0 1.0 C4 B:MCO2410 4.8 39.3 1.0 CZ3 B:TRP39 4.9 17.1 1.0 CH2 B:TRP39 4.9 19.2 1.0 OG B:SER221 4.9 15.2 1.0 C6 B:MCO2410 5.0 41.6 1.0

L.Nauton, R.Kahn, G.Garau, J.F.Hernandez, O.Dideberg. Structural Insights Into the Design of Inhibitors For the L1 Metallo-Beta-Lactamase From Stenotrophomonas Maltophilia. J.Mol.Biol. V. 375 257 2008.
ISSN: ISSN 0022-2836
PubMed: 17999929
DOI: 10.1016/J.JMB.2007.10.036