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Atomistry » Zinc » PDB 2c6p-2ci7 » 2chm » |
Zinc in PDB 2chm: Crystal Structure of N2 Substituted Pyrazolo Pyrimidinones - A Flipped Binding Mode in PDE5Enzymatic activity of Crystal Structure of N2 Substituted Pyrazolo Pyrimidinones - A Flipped Binding Mode in PDE5
All present enzymatic activity of Crystal Structure of N2 Substituted Pyrazolo Pyrimidinones - A Flipped Binding Mode in PDE5:
3.1.4.17; 3.1.4.35; Protein crystallography data
The structure of Crystal Structure of N2 Substituted Pyrazolo Pyrimidinones - A Flipped Binding Mode in PDE5, PDB code: 2chm
was solved by
C.M.N.Allerton,
C.G.Barber,
K.C.Beaumont,
D.G.Brown,
S.M.Cole,
D.Ellis,
C.A.L.Lane,
G.N.Maw,
N.M.Mount,
D.J.Rawson,
C.M.Robinson,
S.D.A.Street,
N.W.Summerhill,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2chm:
The structure of Crystal Structure of N2 Substituted Pyrazolo Pyrimidinones - A Flipped Binding Mode in PDE5 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of N2 Substituted Pyrazolo Pyrimidinones - A Flipped Binding Mode in PDE5
(pdb code 2chm). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of N2 Substituted Pyrazolo Pyrimidinones - A Flipped Binding Mode in PDE5, PDB code: 2chm: Zinc binding site 1 out of 1 in 2chmGo back to Zinc Binding Sites List in 2chm
Zinc binding site 1 out
of 1 in the Crystal Structure of N2 Substituted Pyrazolo Pyrimidinones - A Flipped Binding Mode in PDE5
Mono view Stereo pair view
Reference:
C.M.N.Allerton,
C.G.Barber,
K.C.Beaumont,
D.G.Brown,
S.M.Cole,
D.Ellis,
C.A.L.Lane,
G.N.Maw,
N.M.Mount,
D.J.Rawson,
C.M.Robinson,
S.D.A.Street,
N.W.Summerhill.
A Novel Series of Potent and Selective PDE5 Inhibitors with Potential For High and Dose-Independent Oral Bioavailability J.Med.Chem. V. 49 3581 2006.
Page generated: Wed Dec 16 03:19:16 2020
ISSN: ISSN 0022-2623 PubMed: 16759100 DOI: 10.1021/JM060113E |
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