Zinc in PDB 2c3a: Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry

The structure of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry, PDB code: 2c3a was solved by C.Krummenacher, V.M.Supekar, J.C.Whitbeck, E.Lazear, S.A.Connolly, R.J.Eisenberg, G.H.Cohen, D.C.Wiley, A.Carfi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.00 / 2.5
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	67.629, 79.105, 123.563, 90.00, 90.00, 90.00
R / Rfree (%)	22.6 / 27.5

The structure of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry also contains other interesting chemical elements:

Chlorine	(Cl)	2 atoms
Sodium	(Na)	2 atoms

The binding sites of Zinc atom in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry (pdb code 2c3a). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry, PDB code: 2c3a:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1310 b:69.0 occ:0.50 OE2 A:GLU226 2.3 47.6 1.0 CD A:GLU146 2.8 42.3 1.0 OE2 A:GLU146 3.0 44.6 1.0 CD A:GLU226 3.1 45.2 1.0 NE A:ARG229 4.4 42.5 1.0 NH2 A:ARG229 4.5 44.2 1.0 CZ A:ARG229 4.9 45.0 1.0

Zinc binding site 2 out of 5 in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1313 b:54.0 occ:1.00 OD1 B:ASP147 2.1 37.4 1.0 CG B:ASP147 3.0 37.4 1.0 OD2 B:ASP147 3.1 36.4 1.0 OG B:SER145 4.1 29.6 1.0 CB B:ASN72 4.3 25.7 1.0 CB B:ASP147 4.4 35.5 1.0 N B:GLY150 4.5 25.1 1.0 CB B:LEU149 4.5 28.4 1.0 C B:LEU149 4.7 26.4 1.0 CA B:GLY150 4.8 24.9 1.0 CA B:ASN72 5.0 25.7 1.0

Zinc binding site 3 out of 5 in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1314 b:40.1 occ:1.00 OD2 B:ASP215 1.8 35.5 1.0 NE2 B:HIS39 1.9 34.0 1.0 CG B:ASP215 2.7 35.4 1.0 CE1 B:HIS39 2.8 36.0 1.0 OD1 B:ASP215 2.9 34.8 1.0 CD2 B:HIS39 3.0 35.7 1.0 ND1 B:HIS39 3.9 35.3 1.0 NH2 B:ARG134 4.0 37.3 1.0 CG B:HIS39 4.0 34.0 1.0 CB B:ASP215 4.2 34.1 1.0 CB B:TYR38 4.8 34.6 1.0

Zinc binding site 4 out of 5 in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1315 b:36.4 occ:1.00 OD2 B:ASP301 2.0 37.9 1.0 O B:HOH2035 2.3 4.0 1.0 OD1 B:ASP301 2.7 32.6 1.0 CG B:ASP301 2.7 37.6 1.0 CB B:ALA303 4.2 48.7 1.0 CB B:ASP301 4.2 38.4 1.0

Zinc binding site 5 out of 5 in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1316 b:60.1 occ:1.00 OD2 B:ASP272 1.7 46.3 1.0 ND1 B:HIS242 2.5 41.7 1.0 CG B:ASP272 2.9 51.3 1.0 CG B:HIS242 3.1 35.8 1.0 CE1 B:HIS242 3.3 41.5 1.0 CB B:HIS242 3.4 29.4 1.0 OD1 B:ASP272 3.5 49.9 1.0 CD2 B:HIS242 4.0 42.9 1.0 CB B:ASP272 4.0 52.2 1.0 NZ B:LYS245 4.1 32.9 1.0 NE2 B:HIS242 4.1 44.1 1.0 CE B:LYS245 4.5 31.9 1.0 CB B:GLU274 4.7 48.0 1.0 CA B:HIS242 4.7 29.0 1.0 O B:GLU274 4.8 49.2 1.0

C.Krummenacher, V.M.Supekar, J.C.Whitbeck, E.Lazear, S.A.Connolly, R.J.Eisenberg, G.H.Cohen, D.C.Wiley, A.Carfi. Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry. Embo J. V. 24 4144 2005.
ISSN: ISSN 0261-4189
PubMed: 16292345
DOI: 10.1038/SJ.EMBOJ.7600875