Zinc in PDB 2alw: Golgi Alpha-Mannosidase II Complex with Noeuromycin

All present enzymatic activity of Golgi Alpha-Mannosidase II Complex with Noeuromycin:
3.2.1.114;

The structure of Golgi Alpha-Mannosidase II Complex with Noeuromycin, PDB code: 2alw was solved by D.A.Kuntz, M.B.Bols, H.Liu, D.R.Rose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.85 / 1.86
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	68.502, 109.190, 138.148, 90.00, 90.00, 90.00
R / Rfree (%)	14.1 / 18.1

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II Complex with Noeuromycin (pdb code 2alw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II Complex with Noeuromycin, PDB code: 2alw:

Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II Complex with Noeuromycin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II Complex with Noeuromycin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn5001 b:14.8 occ:1.00 NE2 A:HIS90 2.1 10.9 1.0 NE2 A:HIS471 2.1 11.1 1.0 OD1 A:ASP92 2.2 13.8 1.0 OD1 A:ASP204 2.2 12.5 1.0 O5 A:MNM4001 2.3 12.0 1.0 O4 A:MNM4001 2.3 12.4 1.0 CD2 A:HIS471 3.0 11.5 1.0 CD2 A:HIS90 3.0 11.5 1.0 CG A:ASP92 3.1 13.0 1.0 C2 A:MNM4001 3.1 12.7 1.0 CE1 A:HIS90 3.1 11.8 1.0 C1 A:MNM4001 3.1 11.4 1.0 CE1 A:HIS471 3.2 10.2 1.0 CG A:ASP204 3.2 12.4 1.0 OD2 A:ASP92 3.4 14.4 1.0 CB A:ASP204 3.6 9.5 1.0 N6 A:MNM4001 3.7 13.7 1.0 OD2 A:ASP472 4.0 11.4 1.0 C3 A:MNM4001 4.1 13.3 1.0 CG A:HIS471 4.2 10.2 1.0 CG A:HIS90 4.2 8.4 1.0 ND1 A:HIS90 4.2 11.9 1.0 ND1 A:HIS471 4.2 9.7 1.0 OD2 A:ASP204 4.3 11.6 1.0 CE1 A:HIS470 4.4 12.0 1.0 CB A:ASP92 4.4 11.4 1.0 O A:HOH5517 4.7 10.8 1.0 OH A:TYR269 4.8 15.9 1.0 CA A:ASP92 4.9 12.8 1.0 O7 A:MNM4001 4.9 12.7 1.0 NE2 A:HIS470 4.9 12.0 1.0 C10 A:MNM4001 4.9 14.1 1.0 CG A:ASP472 5.0 12.0 1.0

D.A.Kuntz, H.Liu, M.Bols, D.R.Rose. The Role of the Active Site Zn in the Catalytic Mechanism of the GH38 Golgi Alpha-Mannosidase II: Implications From Noeuromycin Inhibition Biocatal.Biotransfor. V. 34 55 2006.
ISSN: ISSN 1024-2422