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Atomistry » Zinc » PDB 2a25-2aer » 2a4g | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 2a25-2aer » 2a4g » |
Zinc in PDB 2a4g: Hepatitis C Protease NS3-4A Serine Protease with Ketoamide Inhibitor SCH225724 BoundProtein crystallography data
The structure of Hepatitis C Protease NS3-4A Serine Protease with Ketoamide Inhibitor SCH225724 Bound, PDB code: 2a4g
was solved by
A.Arasappan,
F.G.Njoroge,
T.Y.Chan,
F.Bennett,
S.L.Bogen,
K.Chen,
H.Gu,
L.Hong,
E.Jao,
Y.T.Liu,
R.G.Lovey,
T.Parekh,
R.E.Pike,
P.Pinto,
B.Santhanam,
S.Venkatraman,
H.Vaccaro,
H.Wang,
X.Yang,
Z.Zhu,
B.Mckittrick,
A.K.Saksena,
V.Girijavallabhan,
J.Pichardo,
N.Butkiewicz,
R.Ingram,
B.Malcolm,
A.J.Prongay,
N.Yao,
B.Marten,
V.Madison,
S.Kemp,
O.Levy,
M.Lim-Wilby,
S.Tamura,
A.K.Ganguly,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Hepatitis C Protease NS3-4A Serine Protease with Ketoamide Inhibitor SCH225724 Bound
(pdb code 2a4g). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Hepatitis C Protease NS3-4A Serine Protease with Ketoamide Inhibitor SCH225724 Bound, PDB code: 2a4g: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 2a4gGo back to Zinc Binding Sites List in 2a4g
Zinc binding site 1 out
of 2 in the Hepatitis C Protease NS3-4A Serine Protease with Ketoamide Inhibitor SCH225724 Bound
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 2a4gGo back to Zinc Binding Sites List in 2a4g
Zinc binding site 2 out
of 2 in the Hepatitis C Protease NS3-4A Serine Protease with Ketoamide Inhibitor SCH225724 Bound
Mono view Stereo pair view
Reference:
A.Arasappan,
F.G.Njoroge,
T.Y.Chan,
F.Bennett,
S.L.Bogen,
K.Chen,
H.Gu,
L.Hong,
E.Jao,
Y.T.Liu,
R.G.Lovey,
T.Parekh,
R.E.Pike,
P.Pinto,
B.Santhanam,
S.Venkatraman,
H.Vaccaro,
H.Wang,
X.Yang,
Z.Zhu,
B.Mckittrick,
A.K.Saksena,
V.Girijavallabhan,
J.Pichardo,
N.Butkiewicz,
R.Ingram,
B.Malcolm,
A.J.Prongay,
N.Yao,
B.Marten,
V.Madison,
S.Kemp,
O.Levy,
M.Lim-Wilby,
S.Tamura,
A.K.Ganguly.
Hepatitis C Virus NS3-4A Serine Protease Inhibitors. Sar of P2' Moiety with Improved Potency. Bioorg.Med.Chem.Lett. V. 15 4180 2005.
Page generated: Wed Dec 16 03:16:32 2020
ISSN: ISSN 0960-894X PubMed: 16087332 DOI: 10.1016/J.BMCL.2005.06.091 |
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