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Atomistry » Zinc » PDB 1z3j-1zfk » 1ze8 » |
Zinc in PDB 1ze8: Carbonic Anhydrase II in Complex with A Membrane-Impermeant Sulfonamide InhibitorEnzymatic activity of Carbonic Anhydrase II in Complex with A Membrane-Impermeant Sulfonamide Inhibitor
All present enzymatic activity of Carbonic Anhydrase II in Complex with A Membrane-Impermeant Sulfonamide Inhibitor:
4.2.1.1; Protein crystallography data
The structure of Carbonic Anhydrase II in Complex with A Membrane-Impermeant Sulfonamide Inhibitor, PDB code: 1ze8
was solved by
V.Menchise,
G.De Simone,
V.Alterio,
A.Di Fiore,
C.Pedone,
A.Scozzafava,
C.T.Supuran,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 1ze8:
The structure of Carbonic Anhydrase II in Complex with A Membrane-Impermeant Sulfonamide Inhibitor also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Carbonic Anhydrase II in Complex with A Membrane-Impermeant Sulfonamide Inhibitor
(pdb code 1ze8). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase II in Complex with A Membrane-Impermeant Sulfonamide Inhibitor, PDB code: 1ze8: Zinc binding site 1 out of 1 in 1ze8Go back to Zinc Binding Sites List in 1ze8
Zinc binding site 1 out
of 1 in the Carbonic Anhydrase II in Complex with A Membrane-Impermeant Sulfonamide Inhibitor
Mono view Stereo pair view
Reference:
V.Menchise,
G.De Simone,
V.Alterio,
A.Di Fiore,
C.Pedone,
A.Scozzafava,
C.T.Supuran.
Carbonic Anhydrase Inhibitors: Stacking with PHE131 Determines Active Site Binding Region of Inhibitors As Exemplified By the X-Ray Crystal Structure of A Membrane-Impermeant Antitumor Sulfonamide Complexed with Isozyme II J.Med.Chem. V. 48 5721 2005.
Page generated: Wed Dec 16 03:15:30 2020
ISSN: ISSN 0022-2623 PubMed: 16134940 DOI: 10.1021/JM050333C |
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