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Zinc in PDB 1xw7: Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama

Protein crystallography data

The structure of Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama, PDB code: 1xw7 was solved by Z.L.Wan, K.Huang, B.Xu, Y.C.Chu, S.Q.Hu, P.G.Katsoyannis, M.A.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.10 / 2.30
Space group P 21 3
Cell size a, b, c (Å), α, β, γ (°) 70.852, 70.852, 70.852, 90.00, 90.00, 90.00
R / Rfree (%) 20.5 / 26.9

Other elements in 1xw7:

The structure of Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama (pdb code 1xw7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama, PDB code: 1xw7:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 1xw7

Go back to Zinc Binding Sites List in 1xw7
Zinc binding site 1 out of 2 in the Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn101

b:4.1
occ:0.33
NE2 B:HIS10 2.0 35.1 1.0
CL B:CL102 2.4 1.4 0.3
CE1 B:HIS10 3.0 37.2 1.0
CD2 B:HIS10 3.0 32.7 1.0
ND1 B:HIS10 4.1 35.3 1.0
CG B:HIS10 4.2 31.8 1.0
O B:LEU6 4.6 31.2 1.0
CB B:LEU6 4.9 30.3 1.0

Zinc binding site 2 out of 2 in 1xw7

Go back to Zinc Binding Sites List in 1xw7
Zinc binding site 2 out of 2 in the Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn201

b:7.7
occ:0.33
NE2 D:HIS10 2.0 33.5 1.0
CL D:CL202 2.3 12.5 0.3
CE1 D:HIS10 2.7 32.3 1.0
CD2 D:HIS10 3.2 34.0 1.0
ND1 D:HIS10 3.9 36.1 1.0
CG D:HIS10 4.2 35.1 1.0
O D:LEU6 4.8 41.0 1.0

Reference:

Z.L.Wan, K.Huang, B.Xu, S.Q.Hu, S.Wang, Y.C.Chu, P.G.Katsoyannis, M.A.Weiss. Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama Biochemistry V. 44 5000 2005.
ISSN: ISSN 0006-2960
PubMed: 15794638
DOI: 10.1021/BI047585K
Page generated: Wed Oct 16 20:38:28 2024

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