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Zinc in PDB 1v7a: Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors

Enzymatic activity of Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors

All present enzymatic activity of Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors:
3.5.4.4;

Protein crystallography data

The structure of Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors, PDB code: 1v7a was solved by T.Kinoshita, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.50
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.520, 77.520, 136.200, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors (pdb code 1v7a). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors, PDB code: 1v7a:

Zinc binding site 1 out of 1 in 1v7a

Go back to Zinc Binding Sites List in 1v7a
Zinc binding site 1 out of 1 in the Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn400

b:4.2
occ:1.00
O A:HOH1039 1.9 23.6 1.0
NE2 A:HIS17 2.0 2.0 1.0
NE2 A:HIS15 2.1 2.7 1.0
NE2 A:HIS214 2.1 7.1 1.0
OD2 A:ASP295 2.7 4.5 1.0
CE1 A:HIS17 2.9 4.0 1.0
CE1 A:HIS15 2.9 2.0 1.0
CD2 A:HIS17 3.0 2.0 1.0
CE1 A:HIS214 3.1 8.4 1.0
CD2 A:HIS214 3.1 2.0 1.0
CD2 A:HIS15 3.1 2.3 1.0
CG A:ASP295 3.7 3.0 1.0
ND1 A:HIS17 4.1 2.0 1.0
OD1 A:ASP295 4.1 2.0 1.0
ND1 A:HIS15 4.1 2.2 1.0
CG A:HIS17 4.2 2.0 1.0
CG A:HIS15 4.2 2.0 1.0
ND1 A:HIS214 4.2 3.5 1.0
NE2 A:HIS238 4.2 3.9 1.0
CG A:HIS214 4.2 2.0 1.0
O A:HOH1023 4.3 26.3 1.0
N10 A:FRC1001 4.4 2.0 1.0
O A:HOH1171 4.5 13.2 1.0
C8 A:FRC1001 4.5 2.0 1.0
O9 A:FRC1001 4.8 2.0 1.0
NH1 A:ARG101 4.9 5.9 1.0
CD2 A:HIS238 4.9 3.2 1.0
C5 A:FRC1001 4.9 2.0 1.0
NE A:ARG101 4.9 2.0 1.0

Reference:

T.Terasaka, H.Okumura, K.Tsuji, T.Kato, I.Nakanishi, T.Kinoshita, Y.Kato, M.Kuno, N.Seki, Y.Naoe, T.Inoue, K.Tanaka, K.Nakamura. Structure-Based Design and Synthesis of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors J.Med.Chem. V. 47 2728 2004.
ISSN: ISSN 0022-2623
PubMed: 15139750
DOI: 10.1021/JM0499559
Page generated: Fri Sep 25 23:52:24 2020
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