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Zinc in PDB 1v79: Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors

Enzymatic activity of Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors

All present enzymatic activity of Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors:
3.5.4.4;

Protein crystallography data

The structure of Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors, PDB code: 1v79 was solved by T.Kinoshita, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 12.00 / 2.50
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.230, 77.230, 135.100, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Other elements in 1v79:

The structure of Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors (pdb code 1v79). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors, PDB code: 1v79:

Zinc binding site 1 out of 1 in 1v79

Go back to Zinc Binding Sites List in 1v79
Zinc binding site 1 out of 1 in the Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structures of Adenosine Deaminase Complexed with Potent Inhibitors within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn400

b:19.5
occ:1.00
 O A:HOH1147 1.9 43.3 1.0
NE2 A:HIS17 2.0 2.0 1.0
NE2 A:HIS15 2.1 10.9 1.0
NE2 A:HIS214 2.4 11.8 1.0
OD2 A:ASP295 2.4 16.0 1.0
CD2 A:HIS17 3.0 3.7 1.0
CE1 A:HIS15 3.0 9.2 1.0
CE1 A:HIS17 3.1 7.0 1.0
CD2 A:HIS214 3.2 10.9 1.0
CD2 A:HIS15 3.2 13.1 1.0
CG A:ASP295 3.3 17.7 1.0
OD1 A:ASP295 3.5 18.7 1.0
CE1 A:HIS214 3.5 15.5 1.0
N10 A:FR71001 4.0 10.3 1.0
NE2 A:HIS238 4.1 4.0 1.0
ND1 A:HIS15 4.2 9.2 1.0
CG A:HIS17 4.2 7.7 1.0
O A:HOH1002 4.2 16.2 1.0
ND1 A:HIS17 4.3 5.0 1.0
C8 A:FR71001 4.3 11.1 1.0
CG A:HIS15 4.3 11.2 1.0
CG A:HIS214 4.4 10.6 1.0
ND1 A:HIS214 4.6 14.2 1.0
CB A:ASP295 4.7 16.0 1.0
O9 A:FR71001 4.7 8.8 1.0
CD A:ARG101 4.8 4.4 1.0
C5 A:FR71001 4.8 8.6 1.0
CD2 A:HIS238 4.8 5.3 1.0
OD2 A:ASP296 5.0 9.2 1.0
O A:HOH1099 5.0 38.7 1.0
CA A:ASP295 5.0 14.7 1.0
CE1 A:HIS238 5.0 4.8 1.0

Reference:

T.Terasaka, H.Okumura, K.Tsuji, T.Kato, I.Nakanishi, T.Kinoshita, Y.Kato, M.Kuno, N.Seki, Y.Naoe, T.Inoue, K.Tanaka, K.Nakamura. Structure-Based Design and Synthesis of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors J.Med.Chem. V. 47 2728 2004.
ISSN: ISSN 0022-2623
PubMed: 15139750
DOI: 10.1021/JM0499559
Page generated: Wed Oct 16 19:44:39 2024

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