Zinc in PDB 1u40: Ispf with 4-Diphosphocytidyl-2C-Methyl-D-Erythritol

All present enzymatic activity of Ispf with 4-Diphosphocytidyl-2C-Methyl-D-Erythritol:
4.6.1.12;

The structure of Ispf with 4-Diphosphocytidyl-2C-Methyl-D-Erythritol, PDB code: 1u40 was solved by S.Steinbacher, J.Kaiser, J.Wungsintaweekul, S.Hecht, W.Eisenreich, S.Gerhardt, A.Bacher, F.Rohdich, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 2.80
Space group	I 21 3
Cell size a, b, c (Å), α, β, γ (°)	144.810, 144.810, 144.810, 90.00, 90.00, 90.00
R / Rfree (%)	23.3 / 26.4

The binding sites of Zinc atom in the Ispf with 4-Diphosphocytidyl-2C-Methyl-D-Erythritol (pdb code 1u40). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Ispf with 4-Diphosphocytidyl-2C-Methyl-D-Erythritol, PDB code: 1u40:

Zinc binding site 1 out of 1 in the Ispf with 4-Diphosphocytidyl-2C-Methyl-D-Erythritol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Ispf with 4-Diphosphocytidyl-2C-Methyl-D-Erythritol within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn160 b:46.5 occ:1.00 OD1 A:ASP8 1.9 37.4 1.0 O1B A:CDM669 1.9 58.9 1.0 NE2 A:HIS10 2.0 40.6 1.0 ND1 A:HIS42 2.0 36.3 1.0 CG A:ASP8 2.8 34.5 1.0 CE1 A:HIS42 2.8 35.4 1.0 OD2 A:ASP8 2.9 37.5 1.0 CE1 A:HIS10 2.9 40.5 1.0 CD2 A:HIS10 2.9 38.5 1.0 CG A:HIS42 3.1 31.0 1.0 PB A:CDM669 3.3 62.8 1.0 O2B A:CDM669 3.5 63.8 1.0 CB A:HIS42 3.6 28.4 1.0 NE2 A:HIS42 4.0 32.2 1.0 ND1 A:HIS10 4.0 38.4 1.0 CG A:HIS10 4.1 36.7 1.0 CD2 A:HIS42 4.1 29.6 1.0 O3B A:CDM669 4.2 67.2 1.0 CB A:ASP8 4.2 32.5 1.0 O3A A:CDM669 4.4 59.4 1.0 O A:VAL9 4.5 32.5 1.0 C1M A:CDM669 4.8 71.8 1.0

S.Steinbacher, J.Kaiser, J.Wungsintaweekul, S.Hecht, W.Eisenreich, S.Gerhardt, A.Bacher, F.Rohdich. Structure of 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase Involved in Mevalonate Independent Biosynthesis of Isoprenoids J.Mol.Biol. V. 316 79 2002.
ISSN: ISSN 0022-2836
PubMed: 11829504
DOI: 10.1006/JMBI.2001.5341