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Zinc in PDB 1tqw: Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Seleno- Salacinol

Enzymatic activity of Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Seleno- Salacinol

All present enzymatic activity of Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Seleno- Salacinol:
3.2.1.114;

Protein crystallography data

The structure of Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Seleno- Salacinol, PDB code: 1tqw was solved by D.A.Kuntz, A.Ghavami, B.D.Johnston, B.M.Pinto, D.R.Rose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.37 / 1.20
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 69.007, 110.044, 138.946, 90.00, 90.00, 90.00
R / Rfree (%) 17.5 / 18.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Seleno- Salacinol (pdb code 1tqw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Seleno- Salacinol, PDB code: 1tqw:

Zinc binding site 1 out of 1 in 1tqw

Go back to Zinc Binding Sites List in 1tqw
Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Seleno- Salacinol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Seleno- Salacinol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1400

b:6.5
occ:1.00
NE2 A:HIS471 2.0 5.0 1.0
NE2 A:HIS90 2.1 6.0 1.0
OD1 A:ASP92 2.1 7.5 1.0
OD1 A:ASP204 2.1 5.6 1.0
O2 A:BLT1300 2.1 7.4 1.0
CG A:ASP92 2.9 7.0 1.0
CD2 A:HIS471 3.0 5.3 1.0
CE1 A:HIS90 3.0 6.0 1.0
CE1 A:HIS471 3.0 5.5 1.0
CD2 A:HIS90 3.1 5.7 1.0
OD2 A:ASP92 3.1 8.7 1.0
CG A:ASP204 3.1 6.6 1.0
C2 A:BLT1300 3.2 14.3 1.0
C3 A:BLT1300 3.3 15.5 1.0
CB A:ASP204 3.5 6.3 1.0
OD2 A:ASP472 4.0 6.0 1.0
C1 A:BLT1300 4.1 15.1 1.0
ND1 A:HIS471 4.2 5.5 1.0
CG A:HIS471 4.2 4.7 1.0
ND1 A:HIS90 4.2 6.2 1.0
CG A:HIS90 4.2 6.1 1.0
OD2 A:ASP204 4.2 7.4 1.0
O A:HOH2231 4.3 7.5 1.0
CE1 A:HIS470 4.3 5.7 1.0
CB A:ASP92 4.3 6.6 1.0
SE4 A:BLT1300 4.5 6.3 1.0
OH A:TYR269 4.9 8.5 1.0
CA A:ASP92 4.9 5.8 1.0
CA A:ASP204 5.0 6.3 1.0
CG A:ASP472 5.0 5.8 1.0
O1 A:BLT1300 5.0 12.6 1.0
NE2 A:HIS470 5.0 6.2 1.0

Reference:

D.A.Kuntz, A.Ghavami, B.D.Johnston, B.M.Pinto, D.R.Rose. Insights Into the Mechanism of Drosophila Melanogaster Golgi A-Mannosidase II Through Crystallographic Analysis of the Interactions with Analogues of the Naturally Occurring Glycomimetic Salacinol Tetrahedron Asymmetry V. 16 25 2005.
ISSN: ISSN 0957-4166
Page generated: Wed Dec 16 03:05:30 2020

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