Zinc in PDB 1sg6: Crystal Structure of Aspergillus Nidulans 3-Dehydroquinate Synthase (Andhqs) in Complex with ZN2+ and Nad+, at 1.7D

All present enzymatic activity of Crystal Structure of Aspergillus Nidulans 3-Dehydroquinate Synthase (Andhqs) in Complex with ZN2+ and Nad+, at 1.7D:
4.2.3.4;

The structure of Crystal Structure of Aspergillus Nidulans 3-Dehydroquinate Synthase (Andhqs) in Complex with ZN2+ and Nad+, at 1.7D, PDB code: 1sg6 was solved by C.E.Nichols, A.R.Hawkins, D.K.Stammers, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 1.70
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	90.020, 104.510, 177.440, 90.00, 90.00, 90.00
R / Rfree (%)	19.5 / 25

The binding sites of Zinc atom in the Crystal Structure of Aspergillus Nidulans 3-Dehydroquinate Synthase (Andhqs) in Complex with ZN2+ and Nad+, at 1.7D (pdb code 1sg6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Aspergillus Nidulans 3-Dehydroquinate Synthase (Andhqs) in Complex with ZN2+ and Nad+, at 1.7D, PDB code: 1sg6:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Aspergillus Nidulans 3-Dehydroquinate Synthase (Andhqs) in Complex with ZN2+ and Nad+, at 1.7D


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Aspergillus Nidulans 3-Dehydroquinate Synthase (Andhqs) in Complex with ZN2+ and Nad+, at 1.7D within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1600 b:19.0 occ:1.00 NE2 A:HIS287 2.1 14.3 1.0 NE2 A:HIS271 2.2 18.6 1.0 OE2 A:GLU194 2.3 36.8 1.0 CD A:GLU194 2.9 31.9 1.0 CD2 A:HIS287 3.0 15.7 1.0 CD2 A:HIS271 3.0 12.3 1.0 OE1 A:GLU194 3.1 18.7 1.0 CE1 A:HIS287 3.2 20.8 1.0 CE1 A:HIS271 3.3 24.6 1.0 OD2 A:ASP146 3.9 29.0 1.0 O A:HOH1775 3.9 32.3 1.0 CG A:HIS287 4.2 21.3 1.0 CG A:GLU194 4.2 16.4 1.0 CG2 A:VAL291 4.2 14.9 1.0 ND1 A:HIS287 4.2 17.4 1.0 CG A:HIS271 4.3 15.0 1.0 O A:HOH1848 4.3 42.1 1.0 ND1 A:HIS271 4.3 14.4 1.0 C5N A:NAD1400 4.8 20.4 1.0 NZ A:LYS197 4.9 14.1 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Aspergillus Nidulans 3-Dehydroquinate Synthase (Andhqs) in Complex with ZN2+ and Nad+, at 1.7D


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Aspergillus Nidulans 3-Dehydroquinate Synthase (Andhqs) in Complex with ZN2+ and Nad+, at 1.7D within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1601 b:13.5 occ:1.00 NE2 B:HIS271 2.1 15.2 1.0 OE2 B:GLU194 2.2 20.9 1.0 NE2 B:HIS287 2.2 12.5 1.0 CD B:GLU194 3.0 11.8 1.0 CD2 B:HIS287 3.0 9.5 1.0 CD2 B:HIS271 3.1 7.8 1.0 CE1 B:HIS271 3.1 14.5 1.0 OE1 B:GLU194 3.2 16.1 1.0 CE1 B:HIS287 3.3 12.8 1.0 O B:HOH2130 3.6 45.2 1.0 O B:HOH1718 3.9 20.1 1.0 CG2 B:VAL291 4.1 14.2 1.0 OD2 B:ASP146 4.2 36.2 1.0 ND1 B:HIS271 4.2 9.3 1.0 CG B:HIS271 4.2 13.1 1.0 CG B:HIS287 4.3 10.9 1.0 CG B:GLU194 4.3 8.3 1.0 ND1 B:HIS287 4.3 12.8 1.0 O B:HOH2265 4.4 62.9 1.0 O B:HOH2003 4.6 50.1 1.0 NZ B:LYS197 4.8 9.5 1.0

C.E.Nichols, A.R.Hawkins, D.K.Stammers. Structure of the 'Open' Form of Aspergillus Nidulans 3-Dehydroquinate Synthase at 1.7 A Resolution From Crystals Grown Following Enzyme Turnover. Acta Crystallogr.,Sect.D V. 60 971 2004.
ISSN: ISSN 0907-4449
PubMed: 15103156
DOI: 10.1107/S0907444904004743