Zinc in PDB 1s1g: Crystal Structure of KV4.3 T1 Domain

The structure of Crystal Structure of KV4.3 T1 Domain, PDB code: 1s1g was solved by R.H.Scannevin, K.W.Wang, F.Jow, J.Megules, D.C.Kopsco, W.Edris, K.C.Carroll, Q.Lu, W.X.Xu, Z.B.Xu, A.H.Katz, S.Olland, L.Lin, M.Taylor, M.Stahl, K.Malakian, W.Somers, L.Mosyak, M.R.Bowlby, P.Chanda, K.J.Rhodes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.85 / 2.60
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	84.230, 84.230, 104.990, 90.00, 90.00, 90.00
R / Rfree (%)	22.8 / 27.3

The binding sites of Zinc atom in the Crystal Structure of KV4.3 T1 Domain (pdb code 1s1g). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of KV4.3 T1 Domain, PDB code: 1s1g:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of KV4.3 T1 Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of KV4.3 T1 Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn152 b:60.1 occ:1.00 SG A:CYS132 2.2 54.8 1.0 ND1 A:HIS104 2.3 39.2 1.0 SG B:CYS110 2.4 55.0 1.0 SG A:CYS131 2.4 58.8 1.0 CE1 A:HIS104 3.1 40.2 1.0 CB B:CYS110 3.3 51.1 1.0 CB A:CYS131 3.4 60.6 1.0 CG A:HIS104 3.4 40.6 1.0 CB A:CYS132 3.4 60.6 1.0 N A:CYS132 3.6 61.2 1.0 C A:CYS131 3.6 60.9 1.0 CB A:HIS104 3.7 42.1 1.0 CA A:CYS132 3.9 62.2 1.0 O A:CYS131 4.0 60.3 1.0 CA A:HIS104 4.1 45.5 1.0 CA A:CYS131 4.1 61.7 1.0 NE2 A:HIS104 4.3 42.0 1.0 CD2 A:HIS104 4.4 41.7 1.0 CB B:SER112 4.6 46.7 1.0 CA B:CYS110 4.7 50.4 1.0 N A:CYS131 4.7 63.8 1.0 N A:TYR105 4.8 46.5 1.0 O A:LEU103 4.9 46.5 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of KV4.3 T1 Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of KV4.3 T1 Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn152 b:56.7 occ:1.00 ND1 B:HIS104 2.2 44.8 1.0 SG B:CYS131 2.4 52.9 1.0 SG B:CYS132 2.4 48.7 1.0 CE1 B:HIS104 3.0 43.5 1.0 CB B:CYS131 3.3 55.9 1.0 CG B:HIS104 3.3 44.8 1.0 CB B:CYS132 3.4 52.3 1.0 N B:CYS132 3.5 53.3 1.0 CB B:HIS104 3.7 43.8 1.0 C B:CYS131 3.7 54.9 1.0 CA B:CYS132 3.9 53.6 1.0 CA B:CYS131 4.1 56.4 1.0 CA B:HIS104 4.1 46.0 1.0 O B:CYS131 4.2 55.0 1.0 NE2 B:HIS104 4.2 45.1 1.0 CD2 B:HIS104 4.4 43.9 1.0 N B:CYS131 4.8 59.8 1.0 N B:TYR105 4.9 46.2 1.0

R.H.Scannevin, K.W.Wang, F.Jow, J.Megules, D.C.Kopsco, W.Edris, K.C.Carroll, W.X.Xu, Z.B.Xu, A.H.Katz, S.Olland, L.Lin, M.Taylor, M.Stahl, K.Malakian, W.Somers, L.Mosyak, M.R.Bowlby, P.Chanda, K.J.Rhodes. Two N-Terminal Domains of KV4 K(+) Channels Regulate Binding to and Modulation By KCHIP1. Neuron V. 41 587 2004.
ISSN: ISSN 0896-6273
PubMed: 14980207
DOI: 10.1016/S0896-6273(04)00049-2