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Zinc in PDB 1p6m: Bovine Endothelial Nos Heme Domain with (4S)-N-(4-Amino-5- [Aminoethyl]Aminopentyl)-N'-Nitroguanidine Bound

Enzymatic activity of Bovine Endothelial Nos Heme Domain with (4S)-N-(4-Amino-5- [Aminoethyl]Aminopentyl)-N'-Nitroguanidine Bound

All present enzymatic activity of Bovine Endothelial Nos Heme Domain with (4S)-N-(4-Amino-5- [Aminoethyl]Aminopentyl)-N'-Nitroguanidine Bound:
1.14.13.39;

Protein crystallography data

The structure of Bovine Endothelial Nos Heme Domain with (4S)-N-(4-Amino-5- [Aminoethyl]Aminopentyl)-N'-Nitroguanidine Bound, PDB code: 1p6m was solved by M.L.Flinspach, H.Li, J.Jamal, W.Yang, H.Huang, J.-M.Hah, J.A.Gomez-Vidal, E.A.Litzinger, R.B.Silverman, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.85 / 2.27
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 58.033, 106.085, 156.667, 90.00, 90.00, 90.00
R / Rfree (%) 21.5 / 27.8

Zinc Binding Sites:

The binding sites of Zinc atom in the Bovine Endothelial Nos Heme Domain with (4S)-N-(4-Amino-5- [Aminoethyl]Aminopentyl)-N'-Nitroguanidine Bound (pdb code 1p6m). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Bovine Endothelial Nos Heme Domain with (4S)-N-(4-Amino-5- [Aminoethyl]Aminopentyl)-N'-Nitroguanidine Bound, PDB code: 1p6m:

Zinc binding site 1 out of 1 in 1p6m

Go back to Zinc Binding Sites List in 1p6m
Zinc binding site 1 out of 1 in the Bovine Endothelial Nos Heme Domain with (4S)-N-(4-Amino-5- [Aminoethyl]Aminopentyl)-N'-Nitroguanidine Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Bovine Endothelial Nos Heme Domain with (4S)-N-(4-Amino-5- [Aminoethyl]Aminopentyl)-N'-Nitroguanidine Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn900

b:55.4
occ:1.00
SG B:CYS96 2.3 54.0 1.0
SG B:CYS101 2.3 53.4 1.0
SG A:CYS101 2.3 53.8 1.0
SG A:CYS96 2.3 53.0 1.0
CB A:CYS101 3.2 57.0 1.0
CB B:CYS101 3.3 52.9 1.0
CB B:CYS96 3.5 58.7 1.0
CB A:CYS96 3.6 52.0 1.0
CA A:CYS101 3.7 56.7 1.0
CA B:CYS101 3.8 53.2 1.0
N A:GLY103 4.1 54.2 1.0
N B:GLY103 4.1 48.7 1.0
N A:LEU102 4.2 54.1 1.0
N B:LEU102 4.3 54.9 1.0
C A:CYS101 4.3 54.4 1.0
CA A:GLY103 4.4 53.4 1.0
C B:CYS101 4.4 54.0 1.0
CA B:GLY103 4.5 49.7 1.0
O A:HOH944 4.8 52.8 1.0
CA B:CYS96 4.8 57.2 1.0
CA A:CYS96 5.0 53.5 1.0

Reference:

M.L.Flinspach, H.Li, J.Jamal, W.Yang, H.Huang, J.M.Hah, J.A.Gomez-Vidal, E.A.Litzinger, R.B.Silverman, T.L.Poulos. Structural Basis For Dipeptide Amide Isoform-Selective Inhibition of Neuronal Nitric Oxide Synthase. Nat.Struct.Mol.Biol. V. 11 54 2004.
ISSN: ISSN 1545-9993
PubMed: 14718923
DOI: 10.1038/NSMB704
Page generated: Fri Sep 25 22:57:36 2020
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