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Zinc in PDB 1oez: Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase

Enzymatic activity of Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase

All present enzymatic activity of Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase:
1.15.1.1;

Protein crystallography data

The structure of Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase, PDB code: 1oez was solved by R.W.Strange, S.Antonyuk, M.A.Hough, P.Doucette, J.Rodriguez, J.S.Elam, P.J.Hart, L.J.Hayward, J.S.Valentine, S.S.Hasnain, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.15
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 190.812, 190.812, 34.666, 90.00, 90.00, 90.00
R / Rfree (%) 20.6 / 23.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase (pdb code 1oez). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase, PDB code: 1oez:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 1oez

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Zinc binding site 1 out of 4 in the Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase within 5.0Å range:
probe atom residue distance (Å) B Occ
W:Zn1154

b:19.2
occ:1.00
 ND1 W:HIS80 1.8 9.2 1.0
ND1 W:HIS63 2.0 14.7 1.0
OD2 W:ASP83 2.2 12.7 1.0
OD1 W:ASP83 2.3 16.3 1.0
O W:HOH2067 2.4 45.9 1.0
CG W:ASP83 2.7 13.8 1.0
CE1 W:HIS80 2.7 13.5 1.0
CE1 W:HIS63 2.9 15.0 1.0
CG W:HIS80 3.0 12.0 1.0
CG W:HIS63 3.0 15.6 1.0
CB W:HIS63 3.4 15.0 1.0
CB W:HIS80 3.5 10.3 1.0
N W:HIS80 3.8 10.7 1.0
NE2 W:HIS80 3.9 12.4 1.0
NE2 W:HIS63 4.0 15.4 1.0
CD2 W:HIS80 4.0 11.8 1.0
CD2 W:HIS63 4.1 14.3 1.0
CB W:ASP83 4.2 14.8 1.0
CA W:HIS80 4.3 10.8 1.0
NE W:ARG46 4.5 24.1 1.0
C W:ARG79 4.6 12.5 1.0
CD W:ARG46 4.6 23.1 1.0
CA W:ARG79 4.7 14.4 1.0
O W:GLU78 4.9 19.5 1.0
CA W:HIS63 4.9 15.3 1.0
N W:ARG79 5.0 16.8 1.0

Zinc binding site 2 out of 4 in 1oez

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Zinc binding site 2 out of 4 in the Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase within 5.0Å range:
probe atom residue distance (Å) B Occ
X:Zn1154

b:18.6
occ:1.00
 ND1 X:HIS63 1.9 15.0 1.0
ND1 X:HIS80 1.9 13.5 1.0
OD1 X:ASP83 2.4 19.2 1.0
OD2 X:ASP83 2.4 21.1 1.0
O X:HOH2066 2.6 39.4 1.0
CG X:ASP83 2.8 19.0 1.0
CE1 X:HIS80 2.8 19.1 1.0
CE1 X:HIS63 2.8 15.6 1.0
CG X:HIS63 3.0 15.4 1.0
CG X:HIS80 3.0 16.5 1.0
CB X:HIS63 3.4 15.1 1.0
CB X:HIS80 3.5 14.7 1.0
N X:HIS80 3.8 14.7 1.0
NE2 X:HIS63 4.0 16.5 1.0
NE2 X:HIS80 4.0 17.4 1.0
CD2 X:HIS63 4.1 13.4 1.0
CD2 X:HIS80 4.1 17.8 1.0
CA X:HIS80 4.3 15.1 1.0
CB X:ASP83 4.3 18.9 1.0
NE X:ARG46 4.5 23.8 1.0
C X:ARG79 4.6 15.1 1.0
CD X:ARG46 4.8 20.5 1.0
O X:GLU78 4.8 21.4 1.0
CA X:ARG79 4.8 16.3 1.0
CA X:HIS63 4.9 15.2 1.0

Zinc binding site 3 out of 4 in 1oez

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Zinc binding site 3 out of 4 in the Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase within 5.0Å range:
probe atom residue distance (Å) B Occ
Y:Zn1154

b:17.7
occ:1.00
 ND1 Y:HIS80 1.8 9.5 1.0
ND1 Y:HIS63 2.0 13.1 1.0
OD2 Y:ASP83 2.1 16.4 1.0
O Y:HOH2067 2.4 46.6 1.0
OD1 Y:ASP83 2.5 20.8 1.0
CE1 Y:HIS80 2.7 15.5 1.0
CG Y:ASP83 2.7 15.8 1.0
CE1 Y:HIS63 2.9 13.7 1.0
CG Y:HIS80 2.9 11.0 1.0
CG Y:HIS63 3.0 13.3 1.0
CB Y:HIS80 3.4 11.0 1.0
CB Y:HIS63 3.4 14.4 1.0
N Y:HIS80 3.8 12.7 1.0
NE2 Y:HIS80 3.8 13.7 1.0
O Y:GLU78 3.9 24.3 1.0
CD2 Y:HIS80 4.0 9.6 1.0
NE2 Y:HIS63 4.0 13.8 1.0
CD2 Y:HIS63 4.1 12.0 1.0
CB Y:ASP83 4.2 15.5 1.0
CA Y:HIS80 4.2 11.7 1.0
C Y:GLU78 4.6 22.0 1.0
NE Y:ARG46 4.6 24.8 1.0
C Y:ARG79 4.6 14.4 1.0
CA Y:ARG79 4.9 16.3 1.0
CD Y:ARG46 4.9 20.2 1.0
CA Y:HIS63 5.0 15.0 1.0

Zinc binding site 4 out of 4 in 1oez

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Zinc binding site 4 out of 4 in the Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Zn HIS46ARG Mutant of Human Cu, Zn Superoxide Dismutase within 5.0Å range:
probe atom residue distance (Å) B Occ
Z:Zn1154

b:17.6
occ:1.00
 ND1 Z:HIS80 1.8 12.8 1.0
ND1 Z:HIS63 1.8 13.4 1.0
OD2 Z:ASP83 2.2 16.4 1.0
O Z:HOH2076 2.4 44.7 1.0
OD1 Z:ASP83 2.5 13.8 1.0
CE1 Z:HIS80 2.7 17.6 1.0
CG Z:ASP83 2.8 14.8 1.0
CE1 Z:HIS63 2.8 12.2 1.0
CG Z:HIS80 2.9 13.9 1.0
CG Z:HIS63 2.9 15.7 1.0
CB Z:HIS63 3.3 14.3 1.0
CB Z:HIS80 3.4 14.3 1.0
NE2 Z:HIS80 3.8 16.6 1.0
N Z:HIS80 3.8 15.5 1.0
NE2 Z:HIS63 3.9 14.6 1.0
CD2 Z:HIS80 3.9 15.6 1.0
CD2 Z:HIS63 4.0 15.1 1.0
CA Z:HIS80 4.3 14.8 1.0
CB Z:ASP83 4.3 16.5 1.0
NH1 Z:ARG46 4.6 36.9 1.0
C Z:ARG79 4.7 16.6 1.0
CA Z:ARG79 4.8 18.0 1.0
CD Z:ARG46 4.9 24.7 1.0
CA Z:HIS63 4.9 14.8 1.0
O Z:GLU78 4.9 22.6 1.0

Reference:

J.S.Elam, A.B.Taylor, R.W.Strange, S.Antonyuk, P.Doucette, J.Rodriguez, S.S.Hasnain, L.J.Hayward, J.S.Valentine, T.O.Yeates, P.J.Hart. Amyloid-Like Filaments and Water-Filled Nanotubes Formed By SOD1 Mutant Proteins Linked to Familial Als Nat.Struct.Biol. V. 10 461 2003.
ISSN: ISSN 1072-8368
PubMed: 12754496
DOI: 10.1038/NSB935
Page generated: Wed Oct 16 17:30:10 2024

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