Zinc in PDB 1oco: Bovine Heart Cytochrome C Oxidase in Carbon Monoxide-Bound State

All present enzymatic activity of Bovine Heart Cytochrome C Oxidase in Carbon Monoxide-Bound State:
1.9.3.1;

The structure of Bovine Heart Cytochrome C Oxidase in Carbon Monoxide-Bound State, PDB code: 1oco was solved by T.Tsukihara, M.Yao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	7.00 / 2.80
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	189.100, 210.500, 178.600, 90.00, 90.00, 90.00
R / Rfree (%)	21.3 / 25.6

The structure of Bovine Heart Cytochrome C Oxidase in Carbon Monoxide-Bound State also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Iron	(Fe)	4 atoms
Copper	(Cu)	6 atoms
Sodium	(Na)	2 atoms

The binding sites of Zinc atom in the Bovine Heart Cytochrome C Oxidase in Carbon Monoxide-Bound State (pdb code 1oco). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Bovine Heart Cytochrome C Oxidase in Carbon Monoxide-Bound State, PDB code: 1oco:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Bovine Heart Cytochrome C Oxidase in Carbon Monoxide-Bound State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Bovine Heart Cytochrome C Oxidase in Carbon Monoxide-Bound State within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn99 b:20.7 occ:1.00 SG F:CYS85 2.1 20.8 1.0 SG F:CYS82 2.2 16.7 1.0 SG F:CYS62 2.2 25.7 1.0 SG F:CYS60 2.2 23.5 1.0 CB F:CYS82 2.9 22.7 1.0 CB F:CYS60 3.2 14.8 1.0 CB F:CYS62 3.5 14.3 1.0 CB F:CYS85 3.6 12.5 1.0 CA F:CYS62 3.7 21.1 1.0 N F:CYS62 3.9 20.2 1.0 N F:CYS85 4.0 22.8 1.0 OG F:SER84 4.0 43.0 1.0 CA F:CYS85 4.3 21.0 1.0 O F:CYS60 4.3 27.4 1.0 C F:CYS60 4.4 20.3 1.0 CA F:CYS60 4.4 12.9 1.0 CA F:CYS82 4.4 18.0 1.0 CB F:THR87 4.7 19.3 1.0 OG1 F:THR87 4.7 24.7 1.0 C F:SER84 4.9 25.6 1.0 C F:ILE61 4.9 21.6 1.0 C F:CYS85 4.9 25.4 1.0 OH F:TYR89 5.0 15.6 1.0 N F:ILE61 5.0 22.7 1.0 C F:CYS82 5.0 19.6 1.0

Zinc binding site 2 out of 2 in the Bovine Heart Cytochrome C Oxidase in Carbon Monoxide-Bound State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Bovine Heart Cytochrome C Oxidase in Carbon Monoxide-Bound State within 5.0Å range: probe atom residue distance (Å) B Occ S:Zn99 b:30.1 occ:1.00 SG S:CYS85 2.1 35.1 1.0 SG S:CYS60 2.2 26.5 1.0 SG S:CYS62 2.2 27.9 1.0 SG S:CYS82 2.2 31.8 1.0 CB S:CYS82 2.9 29.0 1.0 CB S:CYS60 3.2 19.8 1.0 CB S:CYS62 3.5 16.8 1.0 CB S:CYS85 3.6 37.9 1.0 CA S:CYS62 3.7 25.8 1.0 N S:CYS62 4.0 25.6 1.0 N S:CYS85 4.0 35.9 1.0 OG S:SER84 4.2 38.1 1.0 CA S:CYS85 4.3 34.3 1.0 CA S:CYS82 4.4 25.4 1.0 CA S:CYS60 4.4 18.8 1.0 C S:CYS60 4.5 23.8 1.0 O S:CYS60 4.6 23.3 1.0 CB S:THR87 4.6 27.2 1.0 OG1 S:THR87 4.6 31.9 1.0 C S:CYS85 4.8 35.5 1.0 OH S:TYR89 4.9 34.7 1.0 C S:SER84 4.9 40.1 1.0 C S:ILE61 4.9 25.3 1.0 C S:CYS82 5.0 23.4 1.0

S.Yoshikawa, K.Shinzawa-Itoh, R.Nakashima, R.Yaono, E.Yamashita, N.Inoue, M.Yao, M.J.Fei, C.P.Libeu, T.Mizushima, H.Yamaguchi, T.Tomizaki, T.Tsukihara. Redox-Coupled Crystal Structural Changes in Bovine Heart Cytochrome C Oxidase. Science V. 280 1723 1998.
ISSN: ISSN 0036-8075
PubMed: 9624044
DOI: 10.1126/SCIENCE.280.5370.1723