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Zinc in PDB 1nl4: Crystal Structure of Rat Farnesyl Transferase in Complex with A Potent Biphenyl Inhibitor

Protein crystallography data

The structure of Crystal Structure of Rat Farnesyl Transferase in Complex with A Potent Biphenyl Inhibitor, PDB code: 1nl4 was solved by M.L.Curtin, A.S.Florjancic, J.Cohen, W.-J.Gu, D.J.Frost, S.W.Muchmore, H.L.Sham, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.70
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 168.620, 168.620, 69.123, 90.00, 90.00, 120.00
R / Rfree (%) 22.9 / 28.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Rat Farnesyl Transferase in Complex with A Potent Biphenyl Inhibitor (pdb code 1nl4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Rat Farnesyl Transferase in Complex with A Potent Biphenyl Inhibitor, PDB code: 1nl4:

Zinc binding site 1 out of 1 in 1nl4

Go back to Zinc Binding Sites List in 1nl4
Zinc binding site 1 out of 1 in the Crystal Structure of Rat Farnesyl Transferase in Complex with A Potent Biphenyl Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Rat Farnesyl Transferase in Complex with A Potent Biphenyl Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn500

b:30.0
occ:1.00
OD2 B:ASP297 2.0 30.0 1.0
SG B:CYS299 2.1 30.0 1.0
NE2 B:HIS362 2.2 30.0 1.0
OD1 B:ASP297 2.3 30.0 1.0
N3 B:FTL1 2.3 30.0 1.0
CG B:ASP297 2.4 30.0 1.0
CD2 B:HIS362 3.0 30.0 1.0
CB B:CYS299 3.0 30.0 1.0
C10 B:FTL1 3.0 30.0 1.0
CE1 B:HIS362 3.3 30.0 1.0
C5 B:FTL1 3.5 30.0 1.0
N B:CYS299 3.7 30.0 1.0
CB B:ASP297 3.8 30.0 1.0
CE2 B:TYR361 3.9 30.0 1.0
CA B:CYS299 4.0 30.0 1.0
CG B:HIS362 4.1 30.0 1.0
ND1 B:HIS362 4.3 30.0 1.0
C12 B:FTL1 4.3 30.0 1.0
OD2 B:ASP352 4.4 30.0 1.0
C B:ASP297 4.5 30.0 1.0
CG B:ASP352 4.5 30.0 1.0
N4 B:FTL1 4.5 30.0 1.0
OH B:TYR361 4.6 30.0 1.0
CB B:ASP352 4.6 30.0 1.0
O B:ASP297 4.6 30.0 1.0
CA B:ASP297 4.6 30.0 1.0
CD2 B:TYR361 4.7 30.0 1.0
CZ B:TYR361 4.7 30.0 1.0
CA B:ASP352 4.7 30.0 1.0
N B:GLY298 4.7 30.0 1.0
C B:GLY298 4.9 30.0 1.0
N B:TYR300 4.9 30.0 1.0
C B:CYS299 4.9 30.0 1.0
OD1 B:ASP352 5.0 30.0 1.0

Reference:

M.L.Curtin, A.S.Florjancic, J.Cohen, W.-J.Gu, D.J.Frost, S.W.Muchmore, H.L.Sham. Novel and Selective Imidazole-Containing Biphenyl Inhibitors of Protein Farnesyltransferase Bioorg.Med.Chem.Lett. V. 13 1367 2003.
ISSN: ISSN 0960-894X
PubMed: 12657284
DOI: 10.1016/S0960-894X(03)00096-9
Page generated: Fri Sep 25 22:44:58 2020
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