Atomistry » Zinc » PDB 1m2o-1ml2 » 1m9r
Atomistry »
  Zinc »
    PDB 1m2o-1ml2 »
      1m9r »

Zinc in PDB 1m9r: Human Endothelial Nitric Oxide Synthase with 3-Bromo-7- Nitroindazole Bound

Enzymatic activity of Human Endothelial Nitric Oxide Synthase with 3-Bromo-7- Nitroindazole Bound

All present enzymatic activity of Human Endothelial Nitric Oxide Synthase with 3-Bromo-7- Nitroindazole Bound:
1.14.13.39;

Protein crystallography data

The structure of Human Endothelial Nitric Oxide Synthase with 3-Bromo-7- Nitroindazole Bound, PDB code: 1m9r was solved by R.J.Rosenfeld, E.D.Garcin, K.Panda, G.Andersson, A.Aberg, A.V.Wallace, D.J.Stuehr, J.A.Tainer, E.D.Getzoff, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.65 / 2.56
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 68.625, 90.280, 155.490, 90.00, 90.00, 90.00
R / Rfree (%) 20.8 / 26.6

Other elements in 1m9r:

The structure of Human Endothelial Nitric Oxide Synthase with 3-Bromo-7- Nitroindazole Bound also contains other interesting chemical elements:

Bromine (Br) 4 atoms
Iron (Fe) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Endothelial Nitric Oxide Synthase with 3-Bromo-7- Nitroindazole Bound (pdb code 1m9r). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Endothelial Nitric Oxide Synthase with 3-Bromo-7- Nitroindazole Bound, PDB code: 1m9r:

Zinc binding site 1 out of 1 in 1m9r

Go back to Zinc Binding Sites List in 1m9r
Zinc binding site 1 out of 1 in the Human Endothelial Nitric Oxide Synthase with 3-Bromo-7- Nitroindazole Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Endothelial Nitric Oxide Synthase with 3-Bromo-7- Nitroindazole Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn904

b:46.4
occ:1.00
 SG A:CYS94 2.3 48.9 1.0
SG B:CYS94 2.3 52.7 1.0
SG A:CYS99 2.3 49.0 1.0
SG B:CYS99 2.3 46.6 1.0
CB A:CYS99 3.3 47.9 1.0
CB B:CYS99 3.3 48.9 1.0
CB A:CYS94 3.4 56.9 1.0
CB B:CYS94 3.4 59.6 1.0
CA B:CYS99 3.8 49.5 1.0
CA A:CYS99 3.9 48.7 1.0
N B:GLY101 4.1 50.3 1.0
N A:GLY101 4.2 47.4 1.0
N B:LEU100 4.3 48.5 1.0
N A:LEU100 4.3 47.1 1.0
CA B:GLY101 4.4 50.8 1.0
C B:CYS99 4.4 48.3 1.0
C A:CYS99 4.5 48.6 1.0
CA A:GLY101 4.6 48.2 1.0
CA B:CYS94 4.7 61.1 1.0
CA A:CYS94 4.7 57.4 1.0

Reference:

R.J.Rosenfeld, E.D.Garcin, K.Panda, G.Andersson, A.Aberg, A.V.Wallace, G.M.Morris, A.J.Olson, D.J.Stuehr, J.A.Tainer, E.D.Getzoff. Conformational Changes in Nitric Oxide Synthases Induced By Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry V. 41 13915 2002.
ISSN: ISSN 0006-2960
PubMed: 12437348
DOI: 10.1021/BI026313J
Page generated: Sun Oct 13 05:29:17 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy