Atomistry » Zinc » PDB 1m2k-1mkd » 1m9m
Atomistry »
  Zinc »
    PDB 1m2k-1mkd »
      1m9m »

Zinc in PDB 1m9m: Human Endothelial Nitric Oxide Synthase with 6- Nitroindazole Bound

Enzymatic activity of Human Endothelial Nitric Oxide Synthase with 6- Nitroindazole Bound

All present enzymatic activity of Human Endothelial Nitric Oxide Synthase with 6- Nitroindazole Bound:
1.14.13.39;

Protein crystallography data

The structure of Human Endothelial Nitric Oxide Synthase with 6- Nitroindazole Bound, PDB code: 1m9m was solved by R.J.Rosenfeld, E.D.Garcin, K.Panda, G.Andersson, A.Aberg, A.V.Wallace, D.J.Stuehr, J.A.Tainer, E.D.Getzoff, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.03 / 1.96
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 69.757, 90.782, 155.551, 90.00, 90.00, 90.00
R / Rfree (%) 19.3 / 22.3

Other elements in 1m9m:

The structure of Human Endothelial Nitric Oxide Synthase with 6- Nitroindazole Bound also contains other interesting chemical elements:

Iron (Fe) 2 atoms
Sodium (Na) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Endothelial Nitric Oxide Synthase with 6- Nitroindazole Bound (pdb code 1m9m). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Endothelial Nitric Oxide Synthase with 6- Nitroindazole Bound, PDB code: 1m9m:

Zinc binding site 1 out of 1 in 1m9m

Go back to Zinc Binding Sites List in 1m9m
Zinc binding site 1 out of 1 in the Human Endothelial Nitric Oxide Synthase with 6- Nitroindazole Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Endothelial Nitric Oxide Synthase with 6- Nitroindazole Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn903

b:33.1
occ:1.00
 SG B:CYS94 2.3 35.8 1.0
SG A:CYS99 2.3 33.8 1.0
SG A:CYS94 2.3 33.5 1.0
SG B:CYS99 2.3 34.3 1.0
CB A:CYS99 3.2 36.4 1.0
CB B:CYS99 3.2 35.1 1.0
CB B:CYS94 3.4 38.6 1.0
CB A:CYS94 3.4 37.6 1.0
CA B:CYS99 3.7 35.1 1.0
CA A:CYS99 3.7 35.1 1.0
N B:GLY101 4.1 35.5 1.0
N A:LEU100 4.1 33.7 1.0
N A:GLY101 4.2 34.5 1.0
N B:LEU100 4.2 34.7 1.0
C A:CYS99 4.3 35.6 1.0
C B:CYS99 4.3 35.2 1.0
CA B:GLY101 4.4 35.5 1.0
CA A:GLY101 4.5 34.2 1.0
O A:HOH1204 4.6 42.1 1.0
CA A:CYS94 4.7 39.2 1.0
CA B:CYS94 4.8 40.0 1.0
N B:CYS99 5.0 35.9 1.0
N A:CYS99 5.0 36.1 1.0

Reference:

R.J.Rosenfeld, E.D.Garcin, K.Panda, G.Andersson, A.Aberg, A.V.Wallace, G.M.Morris, A.J.Olson, D.J.Stuehr, J.A.Tainer, E.D.Getzoff. Conformational Changes in Nitric Oxide Synthases Induced By Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry V. 41 13915 2002.
ISSN: ISSN 0006-2960
PubMed: 12437348
DOI: 10.1021/BI026313J
Page generated: Wed Dec 16 02:57:01 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy