Zinc in PDB 1kl9: Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA

The structure of Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA, PDB code: 1kl9 was solved by M.C.Nonato, J.Widom, J.Clardy, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 1.90
Space group	P 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	37.280, 44.200, 121.420, 90.00, 90.00, 90.00
R / Rfree (%)	19.8 / 23.3

The binding sites of Zinc atom in the Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA (pdb code 1kl9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA, PDB code: 1kl9:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:32.5 occ:1.00 OD2 A:ASP158 1.8 30.7 1.0 O A:HOH592 1.8 35.7 1.0 NE2 A:HIS154 2.0 29.6 1.0 CG A:ASP158 2.8 30.6 1.0 CD2 A:HIS154 2.9 26.1 1.0 CE1 A:HIS154 3.0 39.9 1.0 CB A:ASP158 3.3 37.2 1.0 OD1 A:ASP158 3.9 39.5 1.0 CG A:HIS154 4.1 24.4 1.0 ND1 A:HIS154 4.1 30.2 1.0 O A:HOH537 4.1 35.7 1.0 CA A:ASP158 4.8 27.8 1.0 O A:ASP158 4.8 29.9 1.0

Zinc binding site 2 out of 4 in the Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:27.8 occ:0.50 CE1 A:HIS10 2.0 17.8 0.5 O A:HOH596 2.1 63.0 1.0 NE2 A:HIS10 2.3 34.2 0.5 NE2 A:HIS10 2.8 38.2 0.5 CE1 A:HIS10 2.9 80.5 0.5 ND1 A:HIS10 3.1 35.9 0.5 CD2 A:HIS10 3.3 29.5 0.5 O A:HOH587 3.4 50.6 1.0 ND1 A:HIS10 4.0 32.2 0.5 CD2 A:HIS10 4.0 36.4 0.5 CG A:HIS10 4.2 31.4 0.5 CG A:HIS10 4.2 33.9 0.5

Zinc binding site 3 out of 4 in the Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn503 b:51.0 occ:1.00 O A:HOH553 3.1 42.0 1.0 NZ A:LYS77 3.1 43.5 1.0 N A:PHE12 3.4 21.1 1.0 CE A:LYS77 3.4 57.9 1.0 N A:LYS11 3.5 19.4 1.0 CB A:HIS10 3.7 28.6 1.0 O A:PHE12 3.8 23.1 1.0 ND1 A:HIS10 3.8 35.9 0.5 CB A:PHE12 3.8 28.1 1.0 CA A:PHE12 4.1 20.4 1.0 CA A:HIS10 4.1 23.1 1.0 C A:HIS10 4.1 22.0 1.0 CG A:HIS10 4.1 31.4 0.5 CG A:HIS10 4.2 33.9 0.5 C A:LYS11 4.2 25.2 1.0 CA A:LYS11 4.2 20.9 1.0 CD1 A:PHE12 4.3 34.0 1.0 C A:PHE12 4.4 25.2 1.0 CB A:LYS11 4.4 28.2 1.0 CG A:PHE12 4.6 23.8 1.0 ND1 A:HIS10 4.7 32.2 0.5 CD2 A:HIS10 4.7 29.5 0.5 CD A:LYS77 4.9 37.0 1.0 CE1 A:HIS10 5.0 17.8 0.5

Zinc binding site 4 out of 4 in the Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of the N-Terminal Segment of Human Eukaryotic Initiation Factor 2ALPHA within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn504 b:61.9 occ:1.00 CE1 A:HIS113 2.7 52.0 1.0 NE2 A:HIS113 2.9 50.9 1.0 ND1 A:HIS113 3.9 59.2 1.0 CD2 A:HIS113 4.1 54.5 1.0 OE2 A:GLU116 4.3 0.9 1.0 CG A:HIS113 4.6 44.2 1.0 OE1 A:GLU116 4.8 71.6 1.0 CD A:GLU116 5.0 46.5 1.0

M.C.Nonato, J.Widom, J.Clardy. Crystal Structure of the N-Terminal Segment of Human Eukaryotic Translation Initiation Factor 2ALPHA J.Biol.Chem. V. 277 17057 2002.
ISSN: ISSN 0021-9258
PubMed: 11859078
DOI: 10.1074/JBC.M111804200