Zinc in PDB 1jwh: Crystal Structure of Human Protein Kinase CK2 Holoenzyme

All present enzymatic activity of Crystal Structure of Human Protein Kinase CK2 Holoenzyme:
2.7.1.37;

The structure of Crystal Structure of Human Protein Kinase CK2 Holoenzyme, PDB code: 1jwh was solved by K.Niefind, B.Guerra, I.Ermakowa, O.G.Issinger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	59.30 / 3.10
Space group	P 63
Cell size a, b, c (Å), α, β, γ (°)	175.990, 175.990, 93.666, 90.00, 90.00, 120.00
R / Rfree (%)	26.7 / 33.8

The binding sites of Zinc atom in the Crystal Structure of Human Protein Kinase CK2 Holoenzyme (pdb code 1jwh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Protein Kinase CK2 Holoenzyme, PDB code: 1jwh:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human Protein Kinase CK2 Holoenzyme


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Protein Kinase CK2 Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn357 b:73.8 occ:1.00 SG C:CYS109 2.2 79.0 1.0 SG C:CYS114 2.2 98.9 1.0 SG C:CYS137 2.3 91.6 1.0 CB C:CYS140 2.8 63.0 1.0 SG C:CYS140 2.9 0.2 1.0 CB C:CYS114 3.2 0.6 1.0 CB C:CYS109 3.2 0.4 1.0 CB C:CYS137 3.3 0.3 1.0 OH C:TYR144 3.4 49.4 1.0 N C:CYS140 3.4 84.6 1.0 CA C:CYS140 3.7 74.1 1.0 CE2 C:TYR144 3.8 50.8 1.0 CZ C:TYR144 4.1 69.5 1.0 CB C:ARG111 4.4 57.6 1.0 CB C:LYS139 4.5 85.1 1.0 C C:LYS139 4.6 90.1 1.0 CA C:CYS109 4.6 95.5 1.0 CD C:ARG111 4.6 71.0 1.0 CA C:CYS114 4.7 0.0 1.0 CA C:CYS137 4.7 80.2 1.0 CG C:ARG111 4.8 56.3 1.0 CB C:GLN117 4.8 0.7 1.0 C C:CYS140 4.9 68.3 1.0 CA C:LYS139 5.0 86.9 1.0 O C:CYS137 5.0 18.8 1.0 CG C:GLN117 5.0 0.6 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human Protein Kinase CK2 Holoenzyme


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Protein Kinase CK2 Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn358 b:72.9 occ:1.00 SG D:CYS114 2.0 82.4 1.0 CB D:CYS140 2.3 21.5 1.0 SG D:CYS109 2.4 47.1 1.0 SG D:CYS137 2.6 58.6 1.0 SG D:CYS140 2.7 58.9 1.0 N D:CYS140 3.1 56.9 1.0 OH D:TYR144 3.2 93.9 1.0 CA D:CYS140 3.3 59.9 1.0 CB D:CYS114 3.5 42.6 1.0 CB D:CYS137 3.6 0.0 1.0 CB D:CYS109 3.8 79.4 1.0 CZ D:TYR144 4.0 87.3 1.0 CE1 D:TYR144 4.2 51.3 1.0 CB D:LYS139 4.2 73.8 1.0 C D:LYS139 4.3 66.1 1.0 CB D:ARG111 4.4 80.8 1.0 CD D:ARG111 4.5 99.5 1.0 C D:CYS140 4.5 57.6 1.0 CG D:LYS139 4.5 90.9 1.0 CA D:CYS114 4.7 99.8 1.0 CD D:LYS139 4.8 88.6 1.0 CA D:LYS139 4.8 82.0 1.0 N D:MET141 4.8 66.9 1.0 CG D:ARG111 4.8 64.3 1.0 NE D:ARG111 4.9 0.8 1.0

K.Niefind, B.Guerra, I.Ermakowa, O.G.Issinger. Crystal Structure of Human Protein Kinase CK2: Insights Into Basic Properties of the CK2 Holoenzyme. Embo J. V. 20 5320 2001.
ISSN: ISSN 0261-4189
PubMed: 11574463
DOI: 10.1093/EMBOJ/20.19.5320