Zinc in PDB 1jm7: Solution Structure of the BRCA1/BARD1 Ring-Domain Heterodimer

The binding sites of Zinc atom in the Solution Structure of the BRCA1/BARD1 Ring-Domain Heterodimer (pdb code 1jm7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Solution Structure of the BRCA1/BARD1 Ring-Domain Heterodimer, PDB code: 1jm7:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Solution Structure of the BRCA1/BARD1 Ring-Domain Heterodimer


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of the BRCA1/BARD1 Ring-Domain Heterodimer within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn123 b:0.0 occ:1.00 HD13 A:ILE26 2.2 0.0 1.0 SG A:CYS24 2.4 0.0 1.0 SG A:CYS44 2.4 0.0 1.0 SG A:CYS47 2.4 0.0 1.0 SG A:CYS27 2.4 0.0 1.0 CD1 A:ILE26 3.2 0.0 1.0 HB2 A:CYS44 3.3 0.0 1.0 HG13 A:ILE26 3.4 0.0 1.0 H A:CYS27 3.5 0.0 1.0 CB A:CYS44 3.5 0.0 1.0 HB2 A:GLU29 3.6 0.0 1.0 HD11 A:ILE26 3.6 0.0 1.0 CG1 A:ILE26 3.8 0.0 1.0 HD12 A:ILE26 3.9 0.0 1.0 CB A:CYS27 3.9 0.0 1.0 H A:GLU29 3.9 0.0 1.0 HB3 A:CYS27 3.9 0.0 1.0 CB A:CYS24 3.9 0.0 1.0 H A:CYS44 4.0 0.0 1.0 HB2 A:CYS24 4.0 0.0 1.0 HG12 A:ILE26 4.1 0.0 1.0 CB A:CYS47 4.1 0.0 1.0 HB3 A:CYS44 4.2 0.0 1.0 O A:GLU29 4.2 0.0 1.0 HB3 A:CYS47 4.2 0.0 1.0 N A:CYS27 4.3 0.0 1.0 HB3 A:CYS24 4.3 0.0 1.0 HG23 A:ILE31 4.4 0.0 1.0 HD2 A:PRO25 4.4 0.0 1.0 HG21 A:ILE31 4.5 0.0 1.0 N A:CYS44 4.5 0.0 1.0 HB2 A:CYS47 4.5 0.0 1.0 CA A:CYS27 4.6 0.0 1.0 CB A:GLU29 4.6 0.0 1.0 HB2 A:CYS27 4.7 0.0 1.0 CA A:CYS44 4.7 0.0 1.0 H A:ILE26 4.7 0.0 1.0 N A:GLU29 4.7 0.0 1.0 H A:LEU28 4.8 0.0 1.0 HG3 A:GLU29 4.8 0.0 1.0 HA A:ILE31 4.8 0.0 1.0 H A:CYS47 4.9 0.0 1.0 HD2 A:PHE43 4.9 0.0 1.0 CG2 A:ILE31 5.0 0.0 1.0

Zinc binding site 2 out of 4 in the Solution Structure of the BRCA1/BARD1 Ring-Domain Heterodimer


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of the BRCA1/BARD1 Ring-Domain Heterodimer within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn124 b:0.0 occ:1.00 HD2 A:HIS41 2.0 0.0 1.0 SG A:CYS39 2.4 0.0 1.0 SG A:CYS64 2.4 0.0 1.0 SG A:CYS61 2.4 0.0 1.0 CD2 A:HIS41 2.4 0.0 1.0 NE2 A:HIS41 2.4 0.0 1.0 HB2 A:LEU63 2.7 0.0 1.0 HB3 A:CYS39 3.1 0.0 1.0 HB3 A:CYS64 3.2 0.0 1.0 H A:CYS64 3.3 0.0 1.0 CB A:CYS39 3.3 0.0 1.0 CB A:CYS64 3.4 0.0 1.0 HB3 A:CYS61 3.5 0.0 1.0 CB A:CYS61 3.6 0.0 1.0 N A:CYS64 3.6 0.0 1.0 HD12 A:LEU63 3.7 0.0 1.0 CG A:HIS41 3.7 0.0 1.0 CE1 A:HIS41 3.7 0.0 1.0 CB A:LEU63 3.7 0.0 1.0 HB2 A:CYS39 3.8 0.0 1.0 HB3 A:LEU63 4.0 0.0 1.0 HB2 A:CYS61 4.0 0.0 1.0 O A:CYS39 4.1 0.0 1.0 CA A:CYS64 4.1 0.0 1.0 C A:LEU63 4.2 0.0 1.0 HB2 A:CYS64 4.3 0.0 1.0 H A:LEU63 4.3 0.0 1.0 ND1 A:HIS41 4.3 0.0 1.0 HE1 A:HIS41 4.4 0.0 1.0 CD1 A:LEU63 4.4 0.0 1.0 CA A:LEU63 4.5 0.0 1.0 HB2 A:HIS41 4.5 0.0 1.0 H A:LYS65 4.5 0.0 1.0 HD13 A:LEU63 4.5 0.0 1.0 CA A:CYS39 4.6 0.0 1.0 CG A:LEU63 4.7 0.0 1.0 N A:LEU63 4.7 0.0 1.0 CB A:HIS41 4.8 0.0 1.0 HA A:CYS64 4.8 0.0 1.0 C A:CYS39 4.8 0.0 1.0 O A:ASN66 4.9 0.0 1.0 CA A:CYS61 4.9 0.0 1.0

Zinc binding site 3 out of 4 in the Solution Structure of the BRCA1/BARD1 Ring-Domain Heterodimer


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Solution Structure of the BRCA1/BARD1 Ring-Domain Heterodimer within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn143 b:0.0 occ:1.00 SG B:CYS71 2.4 0.0 1.0 SG B:CYS53 2.4 0.0 1.0 SG B:CYS74 2.4 0.0 1.0 SG B:CYS50 2.4 0.0 1.0 H B:CYS71 2.5 0.0 1.0 H B:CYS53 2.8 0.0 1.0 HB2 B:ARG52 2.8 0.0 1.0 HB2 B:CYS71 3.0 0.0 1.0 HB2 B:CYS74 3.1 0.0 1.0 CB B:CYS71 3.2 0.0 1.0 CB B:CYS74 3.3 0.0 1.0 N B:CYS71 3.4 0.0 1.0 HB3 B:CYS74 3.6 0.0 1.0 N B:CYS53 3.6 0.0 1.0 HB3 B:PHE70 3.7 0.0 1.0 CB B:CYS53 3.7 0.0 1.0 CB B:CYS50 3.7 0.0 1.0 HB2 B:CYS53 3.7 0.0 1.0 HB3 B:CYS50 3.8 0.0 1.0 HB2 B:CYS50 3.8 0.0 1.0 CB B:ARG52 3.9 0.0 1.0 CA B:CYS71 3.9 0.0 1.0 H B:ARG52 3.9 0.0 1.0 HG2 B:ARG52 4.1 0.0 1.0 HB3 B:CYS71 4.1 0.0 1.0 HG3 B:ARG52 4.2 0.0 1.0 HA B:PHE70 4.2 0.0 1.0 CA B:CYS53 4.3 0.0 1.0 CG B:ARG52 4.3 0.0 1.0 C B:PHE70 4.5 0.0 1.0 CB B:PHE70 4.5 0.0 1.0 HB3 B:ARG52 4.5 0.0 1.0 HD23 B:LEU57 4.5 0.0 1.0 C B:ARG52 4.5 0.0 1.0 HB3 B:CYS53 4.5 0.0 1.0 CA B:ARG52 4.6 0.0 1.0 N B:ARG52 4.6 0.0 1.0 CA B:PHE70 4.6 0.0 1.0 HB3 B:LEU57 4.7 0.0 1.0 HA B:CYS71 4.7 0.0 1.0 CA B:CYS74 4.7 0.0 1.0 HB2 B:PHE70 4.7 0.0 1.0 HA B:CYS53 4.8 0.0 1.0 C B:CYS71 4.9 0.0 1.0 H B:CYS74 5.0 0.0 1.0 N B:CYS74 5.0 0.0 1.0 H B:SER51 5.0 0.0 1.0

Zinc binding site 4 out of 4 in the Solution Structure of the BRCA1/BARD1 Ring-Domain Heterodimer


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Solution Structure of the BRCA1/BARD1 Ring-Domain Heterodimer within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn144 b:0.0 occ:1.00 HB2 B:CYS86 1.7 0.0 1.0 HB2 B:HIS68 2.4 0.0 1.0 CB B:CYS86 2.4 0.0 1.0 SG B:CYS86 2.4 0.0 1.0 SG B:CYS66 2.4 0.0 1.0 SG B:CYS83 2.4 0.0 1.0 ND1 B:HIS68 2.6 0.0 1.0 H B:CYS86 2.7 0.0 1.0 CG B:HIS68 3.1 0.0 1.0 HB3 B:CYS86 3.1 0.0 1.0 CB B:HIS68 3.2 0.0 1.0 HB3 B:CYS83 3.2 0.0 1.0 CB B:CYS83 3.2 0.0 1.0 HB2 B:CYS83 3.2 0.0 1.0 H B:GLU67 3.3 0.0 1.0 N B:CYS86 3.4 0.0 1.0 CA B:CYS86 3.5 0.0 1.0 CE1 B:HIS68 3.5 0.0 1.0 H B:HIS68 3.6 0.0 1.0 HB2 B:CYS66 3.8 0.0 1.0 HB3 B:HIS68 3.9 0.0 1.0 HB B:VAL85 3.9 0.0 1.0 CB B:CYS66 3.9 0.0 1.0 N B:HIS68 4.0 0.0 1.0 HE1 B:HIS68 4.0 0.0 1.0 HG1 B:THR88 4.0 0.0 1.0 HB B:THR88 4.0 0.0 1.0 H B:THR88 4.1 0.0 1.0 CD2 B:HIS68 4.1 0.0 1.0 CA B:HIS68 4.2 0.0 1.0 HA B:CYS86 4.2 0.0 1.0 N B:GLU67 4.3 0.0 1.0 NE2 B:HIS68 4.4 0.0 1.0 OG1 B:THR88 4.4 0.0 1.0 H B:TYR87 4.4 0.0 1.0 C B:CYS86 4.4 0.0 1.0 H B:VAL85 4.4 0.0 1.0 HB3 B:CYS66 4.5 0.0 1.0 H B:CYS66 4.6 0.0 1.0 HZ B:PHE70 4.6 0.0 1.0 C B:VAL85 4.7 0.0 1.0 HA2 B:GLY64 4.7 0.0 1.0 CA B:CYS83 4.7 0.0 1.0 C B:GLU67 4.7 0.0 1.0 N B:TYR87 4.7 0.0 1.0 CB B:THR88 4.7 0.0 1.0 HA B:HIS68 4.8 0.0 1.0 HA3 B:GLY64 4.8 0.0 1.0 CB B:VAL85 4.9 0.0 1.0 HD2 B:HIS68 4.9 0.0 1.0 CA B:CYS66 4.9 0.0 1.0

P.S.Brzovic, P.Rajagopal, D.W.Hoyt, M.C.King, R.E.Klevit. Structure of A BRCA1-BARD1 Heterodimeric Ring-Ring Complex. Nat.Struct.Biol. V. 8 833 2001.
ISSN: ISSN 1072-8368
PubMed: 11573085
DOI: 10.1038/NSB1001-833