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Zinc in PDB 1jca: Non-Standard Design of Unstable Insulin Analogues with Enhanced Activity

Protein crystallography data

The structure of Non-Standard Design of Unstable Insulin Analogues with Enhanced Activity, PDB code: 1jca was solved by M.A.Weiss, Z.Wan, M.Zhao, Y.-C.Chu, S.H.Nakagawa, G.T.Burke, W.Jia, R.Hellmich, P.G.Katsoyannis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 2.50
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 80.652, 80.652, 37.936, 90.00, 90.00, 120.00
R / Rfree (%) 20.4 / 24.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Non-Standard Design of Unstable Insulin Analogues with Enhanced Activity (pdb code 1jca). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Non-Standard Design of Unstable Insulin Analogues with Enhanced Activity, PDB code: 1jca:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 1jca

Go back to Zinc Binding Sites List in 1jca
Zinc binding site 1 out of 2 in the Non-Standard Design of Unstable Insulin Analogues with Enhanced Activity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Non-Standard Design of Unstable Insulin Analogues with Enhanced Activity within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn41

b:19.3
occ:0.33
NE2 B:HIS10 2.2 20.7 1.0
CE1 B:HIS10 3.1 20.1 1.0
CD2 B:HIS10 3.2 18.1 1.0
ND1 B:HIS10 4.2 18.0 1.0
CG B:HIS10 4.3 19.3 1.0

Zinc binding site 2 out of 2 in 1jca

Go back to Zinc Binding Sites List in 1jca
Zinc binding site 2 out of 2 in the Non-Standard Design of Unstable Insulin Analogues with Enhanced Activity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Non-Standard Design of Unstable Insulin Analogues with Enhanced Activity within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn42

b:18.9
occ:0.33
NE2 D:HIS10 1.9 22.2 1.0
CE1 D:HIS10 2.8 23.0 1.0
CD2 D:HIS10 3.0 20.6 1.0
ND1 D:HIS10 4.0 23.0 1.0
CG D:HIS10 4.1 21.8 1.0
O D:LEU6 4.4 20.0 1.0
CB D:LEU6 4.8 23.5 1.0

Reference:

M.A.Weiss, Z.Wan, M.Zhao, Y.C.Chu, S.H.Nakagawa, G.T.Burke, W.Jia, R.Hellmich, P.G.Katsoyannis. Non-Standard Insulin Design: Structure-Activity Relationships at the Periphery of the Insulin Receptor. J.Mol.Biol. V. 315 103 2002.
ISSN: ISSN 0022-2836
PubMed: 11779231
DOI: 10.1006/JMBI.2001.5224
Page generated: Wed Dec 16 02:53:46 2020

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