Zinc in PDB 1hxk: Golgi Alpha-Mannosidase II in Complex with Deoxymannojirimicin

All present enzymatic activity of Golgi Alpha-Mannosidase II in Complex with Deoxymannojirimicin:
3.2.1.114;

The structure of Golgi Alpha-Mannosidase II in Complex with Deoxymannojirimicin, PDB code: 1hxk was solved by J.M.H.Van Den Elsen, D.A.Kuntz, D.R.Rose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	85.90 / 1.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	68.814, 109.616, 138.281, 90.00, 90.00, 90.00
R / Rfree (%)	19.7 / 21.6

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II in Complex with Deoxymannojirimicin (pdb code 1hxk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II in Complex with Deoxymannojirimicin, PDB code: 1hxk:

Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II in Complex with Deoxymannojirimicin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II in Complex with Deoxymannojirimicin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1102 b:8.9 occ:1.00 OD1 A:ASP92 2.1 10.3 1.0 OD1 A:ASP204 2.1 9.7 1.0 NE2 A:HIS90 2.1 8.2 1.0 NE2 A:HIS471 2.1 8.4 1.0 O3 A:DMJ1103 2.3 15.7 1.0 O2 A:DMJ1103 2.4 17.6 1.0 CG A:ASP92 3.0 10.2 1.0 CD2 A:HIS471 3.0 8.3 1.0 CD2 A:HIS90 3.1 8.7 1.0 CE1 A:HIS90 3.1 8.4 1.0 CG A:ASP204 3.1 9.8 1.0 CE1 A:HIS471 3.2 7.7 1.0 C3 A:DMJ1103 3.3 17.0 1.0 C2 A:DMJ1103 3.3 17.5 1.0 OD2 A:ASP92 3.3 11.2 1.0 CB A:ASP204 3.6 9.3 1.0 C4 A:DMJ1103 4.0 17.0 1.0 OD2 A:ASP472 4.0 8.9 1.0 ND1 A:HIS90 4.2 8.5 1.0 CG A:HIS471 4.2 7.8 1.0 CG A:HIS90 4.2 8.4 1.0 O A:HOH2084 4.2 26.6 1.0 OD2 A:ASP204 4.2 10.1 1.0 ND1 A:HIS471 4.3 8.2 1.0 CB A:ASP92 4.3 9.4 1.0 NE2 A:HIS470 4.4 8.4 1.0 C1 A:DMJ1103 4.6 18.1 1.0 O A:HOH1196 4.7 9.4 1.0 O4 A:DMJ1103 4.7 17.0 1.0 OH A:TYR269 4.9 10.6 1.0 CG A:ASP472 5.0 8.6 1.0

J.M.Van Den Elsen, D.A.Kuntz, D.R.Rose. Structure of Golgi Alpha-Mannosidase II: A Target For Inhibition of Growth and Metastasis of Cancer Cells. Embo J. V. 20 3008 2001.
ISSN: ISSN 0261-4189
PubMed: 11406577
DOI: 10.1093/EMBOJ/20.12.3008