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Zinc in PDB 1hcq: The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements

Protein crystallography data

The structure of The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements, PDB code: 1hcq was solved by J.W.R.Schwabe, L.Chapman, J.T.Finch, D.Rhodes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 2.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 51.600, 90.800, 114.600, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements (pdb code 1hcq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements, PDB code: 1hcq:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Zinc binding site 1 out of 8 in 1hcq

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Zinc binding site 1 out of 8 in the The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn598

b:24.0
occ:1.00
 SG A:CYS27 2.1 19.2 1.0
SG A:CYS24 2.2 24.9 1.0
SG A:CYS10 2.2 23.7 1.0
SG A:CYS7 2.5 22.5 1.0
CB A:CYS7 3.2 18.6 1.0
CB A:CYS10 3.3 22.2 1.0
CB A:CYS27 3.3 19.4 1.0
CB A:CYS24 3.4 22.8 1.0
N A:CYS10 3.7 23.9 1.0
N A:CYS27 3.9 17.9 1.0
N A:CYS24 4.1 20.9 1.0
CA A:CYS10 4.1 23.5 1.0
CA A:CYS27 4.2 16.8 1.0
CA A:CYS24 4.3 19.4 1.0
NH1 A:ARG56 4.4 23.4 1.0
CB A:VAL9 4.5 25.4 1.0
C A:VAL9 4.7 25.0 1.0
CA A:CYS7 4.7 19.7 1.0
C A:CYS10 4.7 25.3 1.0
N A:ASP12 4.8 27.8 1.0
CB A:ASP12 4.8 26.0 1.0
N A:ASN11 4.8 25.7 1.0
CD A:ARG56 4.8 22.0 1.0
NH2 A:ARG63 4.9 20.2 1.0
CA A:VAL9 4.9 25.8 1.0
C A:CYS24 5.0 16.6 1.0
O A:CYS24 5.0 16.6 1.0
N A:VAL9 5.0 28.2 1.0
C A:GLY26 5.0 19.0 1.0

Zinc binding site 2 out of 8 in 1hcq

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Zinc binding site 2 out of 8 in the The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn599

b:21.2
occ:1.00
 SG A:CYS49 2.1 19.4 1.0
SG A:CYS59 2.2 21.1 1.0
SG A:CYS43 2.2 20.4 1.0
SG A:CYS62 2.4 23.3 1.0
CB A:CYS59 3.2 18.6 1.0
CB A:CYS49 3.3 21.6 1.0
CB A:CYS62 3.4 22.1 1.0
CB A:CYS43 3.4 22.2 1.0
CD A:PRO44 3.8 16.0 1.0
CA A:CYS43 4.0 24.0 1.0
N A:CYS49 4.1 26.1 1.0
N A:CYS62 4.2 21.5 1.0
CA A:CYS49 4.3 23.9 1.0
CA A:ASN47 4.3 24.8 1.0
O A:HOH608 4.3 24.0 1.0
CA A:CYS62 4.3 23.2 1.0
N A:ASN47 4.4 25.7 1.0
N A:PRO44 4.5 15.6 1.0
CA A:CYS59 4.6 20.6 1.0
N A:GLN48 4.7 22.3 1.0
C A:CYS43 4.7 19.4 1.0
C A:ASN47 4.8 24.5 1.0
CG A:PRO44 4.8 15.1 1.0
N A:ALA45 4.9 19.6 1.0
CB A:ALA61 5.0 21.4 1.0

Zinc binding site 3 out of 8 in 1hcq

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Zinc binding site 3 out of 8 in the The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn598

b:25.2
occ:1.00
 SG B:CYS24 2.1 28.7 1.0
SG B:CYS27 2.1 18.2 1.0
SG B:CYS10 2.2 24.5 1.0
SG B:CYS7 2.3 31.2 1.0
CB B:CYS7 3.2 31.9 1.0
CB B:CYS10 3.3 26.1 1.0
CB B:CYS24 3.3 26.9 1.0
CB B:CYS27 3.4 16.1 1.0
NH1 B:ARG56 3.6 30.3 1.0
N B:CYS10 3.6 27.7 1.0
N B:CYS27 3.9 12.2 1.0
N B:CYS24 4.0 28.6 1.0
CA B:CYS10 4.0 26.2 1.0
CA B:CYS27 4.3 11.5 1.0
CA B:CYS24 4.3 25.5 1.0
CB B:VAL9 4.3 27.8 1.0
N B:ASN11 4.6 29.5 1.0
C B:VAL9 4.6 28.7 1.0
C B:CYS10 4.7 28.6 1.0
CA B:CYS7 4.7 31.4 1.0
NH2 B:ARG63 4.7 20.9 1.0
CB B:ASP12 4.7 31.2 1.0
CZ B:ARG56 4.7 28.6 1.0
N B:ASP12 4.7 31.3 1.0
CD B:ARG56 4.8 27.1 1.0
CA B:VAL9 4.9 29.0 1.0
CG1 B:VAL9 4.9 30.8 1.0
C B:CYS24 4.9 22.1 1.0
N B:VAL9 5.0 34.1 1.0

Zinc binding site 4 out of 8 in 1hcq

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Zinc binding site 4 out of 8 in the The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn599

b:23.4
occ:1.00
 SG B:CYS49 2.1 20.8 1.0
SG B:CYS59 2.2 18.8 1.0
SG B:CYS43 2.2 21.4 1.0
SG B:CYS62 2.4 23.8 1.0
CB B:CYS59 3.1 19.1 1.0
CB B:CYS49 3.3 22.2 1.0
CB B:CYS62 3.3 20.8 1.0
CB B:CYS43 3.5 18.4 1.0
N B:CYS49 3.8 24.5 1.0
CA B:CYS43 4.0 23.0 1.0
N B:CYS62 4.1 16.9 1.0
CA B:CYS49 4.1 23.4 1.0
CD B:PRO44 4.1 21.6 1.0
CA B:CYS62 4.3 20.6 1.0
O B:HOH615 4.3 22.1 1.0
CA B:ASN47 4.4 32.8 1.0
N B:GLN48 4.5 26.9 1.0
CA B:CYS59 4.5 22.2 1.0
N B:ASN47 4.5 35.2 1.0
N B:PRO44 4.7 22.2 1.0
C B:CYS43 4.8 23.8 1.0
CG B:PRO44 4.8 23.5 1.0
C B:ASN47 4.8 30.8 1.0
C B:GLN48 4.9 24.3 1.0

Zinc binding site 5 out of 8 in 1hcq

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Zinc binding site 5 out of 8 in the The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn598

b:26.8
occ:1.00
 SG E:CYS27 2.0 24.3 1.0
SG E:CYS10 2.1 26.3 1.0
SG E:CYS24 2.2 28.2 1.0
SG E:CYS7 2.4 29.0 1.0
CB E:CYS7 3.1 24.0 1.0
CB E:CYS10 3.1 27.4 1.0
N E:CYS10 3.6 29.9 1.0
CB E:CYS27 3.6 25.0 1.0
CB E:CYS24 3.6 27.0 1.0
CA E:CYS10 3.9 29.3 1.0
N E:CYS24 4.0 26.0 1.0
N E:CYS27 4.0 24.3 1.0
CA E:CYS24 4.3 23.3 1.0
CA E:CYS27 4.4 23.4 1.0
CB E:VAL9 4.4 28.6 1.0
NH2 E:ARG63 4.5 33.8 1.0
C E:VAL9 4.5 28.3 1.0
C E:CYS10 4.6 33.6 1.0
CA E:CYS7 4.6 25.4 1.0
CA E:VAL9 4.8 28.9 1.0
N E:VAL9 4.8 31.9 1.0
CB E:ASP12 4.8 33.8 1.0
N E:ASN11 4.9 34.3 1.0
CG1 E:VAL9 4.9 29.0 1.0
N E:ASP12 5.0 31.6 1.0
C E:CYS24 5.0 22.1 1.0

Zinc binding site 6 out of 8 in 1hcq

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Zinc binding site 6 out of 8 in the The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn599

b:39.5
occ:1.00
 SG E:CYS49 2.0 39.1 1.0
SG E:CYS62 2.3 42.5 1.0
SG E:CYS43 2.4 43.1 1.0
SG E:CYS59 2.4 33.7 1.0
CB E:CYS59 3.2 29.1 1.0
CB E:CYS62 3.3 39.0 1.0
CB E:CYS49 3.4 38.7 1.0
CB E:CYS43 3.5 44.2 1.0
N E:CYS49 3.8 37.8 1.0
O E:HOH609 4.1 38.7 1.0
CA E:CYS49 4.1 36.4 1.0
N E:CYS62 4.2 36.5 1.0
O E:HOH611 4.2 50.5 1.0
CA E:CYS62 4.3 38.6 1.0
CA E:CYS43 4.4 42.3 1.0
CD E:PRO44 4.4 41.9 1.0
CA E:ASN47 4.5 41.7 1.0
N E:GLN48 4.5 41.0 1.0
N E:ASN47 4.5 43.3 1.0
CB E:ALA61 4.6 38.5 1.0
CA E:CYS59 4.6 29.2 1.0
C E:ASN47 4.8 40.1 1.0
C E:GLN48 4.9 39.2 1.0
O E:CYS59 5.0 35.5 1.0

Zinc binding site 7 out of 8 in 1hcq

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Zinc binding site 7 out of 8 in the The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn598

b:32.0
occ:1.00
 SG F:CYS27 2.1 26.1 1.0
SG F:CYS10 2.2 29.9 1.0
SG F:CYS24 2.3 33.4 1.0
SG F:CYS7 2.4 33.8 1.0
CB F:CYS10 3.0 26.0 1.0
N F:CYS10 3.3 30.2 1.0
CB F:CYS7 3.3 27.5 1.0
CB F:CYS24 3.5 28.2 1.0
CB F:CYS27 3.5 23.1 1.0
CA F:CYS10 3.7 26.3 1.0
N F:CYS27 3.9 23.8 1.0
N F:CYS24 4.1 31.3 1.0
O F:HOH600 4.1 39.3 1.0
CA F:CYS27 4.3 21.3 1.0
CA F:CYS24 4.3 25.6 1.0
CB F:VAL9 4.3 37.3 1.0
C F:VAL9 4.3 32.8 1.0
C F:CYS10 4.5 29.3 1.0
CA F:CYS7 4.7 26.6 1.0
CA F:VAL9 4.7 35.2 1.0
N F:ASN11 4.8 32.9 1.0
N F:VAL9 4.8 37.5 1.0
CG1 F:VAL9 4.9 39.5 1.0
C F:CYS24 4.9 21.4 1.0

Zinc binding site 8 out of 8 in 1hcq

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Zinc binding site 8 out of 8 in the The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn599

b:39.2
occ:1.00
 SG F:CYS49 2.1 31.6 1.0
SG F:CYS43 2.3 35.2 1.0
SG F:CYS59 2.4 33.1 1.0
SG F:CYS62 2.5 40.7 1.0
CB F:CYS59 3.1 33.0 1.0
CB F:CYS49 3.1 34.8 1.0
CB F:CYS62 3.5 37.4 1.0
CB F:CYS43 3.5 35.7 1.0
N F:CYS49 3.7 36.2 1.0
CD F:PRO44 3.7 39.7 1.0
CA F:CYS49 4.0 36.4 1.0
CA F:CYS43 4.2 37.5 1.0
O F:HOH608 4.3 33.6 1.0
N F:CYS62 4.3 34.9 1.0
CA F:ASN47 4.3 39.0 1.0
N F:ASN47 4.4 39.7 1.0
CG F:PRO44 4.5 38.9 1.0
CA F:CYS62 4.5 36.6 1.0
N F:GLN48 4.5 33.1 1.0
CA F:CYS59 4.6 33.1 1.0
O F:HOH607 4.7 45.2 1.0
N F:PRO44 4.7 38.3 1.0
C F:ASN47 4.8 37.8 1.0
C F:GLN48 4.8 33.5 1.0
C F:CYS43 4.9 38.3 1.0
O F:CYS59 4.9 38.1 1.0
CB F:ALA61 5.0 43.6 1.0

Reference:

J.W.Schwabe, L.Chapman, J.T.Finch, D.Rhodes. The Crystal Structure of the Estrogen Receptor Dna-Binding Domain Bound to Dna: How Receptors Discriminate Between Their Response Elements. Cell(Cambridge,Mass.) V. 75 567 1993.
ISSN: ISSN 0092-8674
PubMed: 8221895
DOI: 10.1016/0092-8674(93)90390-C
Page generated: Sun Oct 13 02:07:27 2024

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