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Zinc in PDB 1fxu: Purine Nucleoside Phosphorylase From Calf Spleen in Complex with N(7)- Acycloguanosine Inhibitor and A Phosphate Ion

Enzymatic activity of Purine Nucleoside Phosphorylase From Calf Spleen in Complex with N(7)- Acycloguanosine Inhibitor and A Phosphate Ion

All present enzymatic activity of Purine Nucleoside Phosphorylase From Calf Spleen in Complex with N(7)- Acycloguanosine Inhibitor and A Phosphate Ion:
2.4.2.1;

Protein crystallography data

The structure of Purine Nucleoside Phosphorylase From Calf Spleen in Complex with N(7)- Acycloguanosine Inhibitor and A Phosphate Ion, PDB code: 1fxu was solved by M.Luic, A.Bzowska, D.Shugar, W.Saenger, G.Koellner, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 22.18 / 2.20
Space group P 21 3
Cell size a, b, c (Å), α, β, γ (°) 94.110, 94.110, 94.110, 90.00, 90.00, 90.00
R / Rfree (%) 17.5 / 24.4

Other elements in 1fxu:

The structure of Purine Nucleoside Phosphorylase From Calf Spleen in Complex with N(7)- Acycloguanosine Inhibitor and A Phosphate Ion also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Purine Nucleoside Phosphorylase From Calf Spleen in Complex with N(7)- Acycloguanosine Inhibitor and A Phosphate Ion (pdb code 1fxu). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Purine Nucleoside Phosphorylase From Calf Spleen in Complex with N(7)- Acycloguanosine Inhibitor and A Phosphate Ion, PDB code: 1fxu:

Zinc binding site 1 out of 1 in 1fxu

Go back to Zinc Binding Sites List in 1fxu
Zinc binding site 1 out of 1 in the Purine Nucleoside Phosphorylase From Calf Spleen in Complex with N(7)- Acycloguanosine Inhibitor and A Phosphate Ion


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Purine Nucleoside Phosphorylase From Calf Spleen in Complex with N(7)- Acycloguanosine Inhibitor and A Phosphate Ion within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn302

b:18.8
occ:0.33
 NE2 A:HIS20 2.1 13.1 1.0
O A:HOH372 2.9 23.0 0.3
CD2 A:HIS20 3.0 11.6 1.0
CE1 A:HIS20 3.1 15.7 1.0
O A:HOH371 3.1 21.4 0.3
CG A:HIS20 4.2 13.4 1.0
O A:HOH335 4.2 17.8 1.0
ND1 A:HIS20 4.2 13.9 1.0
NE1 A:TRP16 4.8 12.5 1.0
CZ2 A:TRP16 5.0 12.5 1.0

Reference:

M.Luic, G.Koellner, D.Shugar, W.Saenger, A.Bzowska. Calf Spleen Purine Nucleoside Phosphorylase: Structure of Its Ternary Complex with An N(7)-Acycloguanosine Inhibitor and A Phosphate Anion. Acta Crystallogr.,Sect.D V. 57 30 2001.
ISSN: ISSN 0907-4449
PubMed: 11134924
DOI: 10.1107/S0907444900014402
Page generated: Wed Dec 16 02:49:43 2020

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