Zinc in PDB 1ftj: Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution

The structure of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution, PDB code: 1ftj was solved by N.Armstrong, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.90
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	114.002, 163.363, 47.396, 90.00, 90.00, 90.00
R / Rfree (%)	22.6 / 26.6

The binding sites of Zinc atom in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution (pdb code 1ftj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution, PDB code: 1ftj:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn269 b:22.1 occ:1.00 OE2 B:GLU166 1.9 19.8 1.0 OE1 A:GLU42 2.0 19.0 1.0 NE2 A:HIS46 2.2 17.9 1.0 CD B:GLU166 2.7 20.1 1.0 OE1 B:GLU166 2.8 18.1 1.0 CD A:GLU42 2.9 18.0 1.0 CD2 A:HIS46 3.1 15.6 1.0 O A:HOH367 3.2 4.9 1.0 CE1 A:HIS46 3.2 18.1 1.0 OE2 A:GLU42 3.2 15.7 1.0 CD2 A:LEU241 4.0 11.8 1.0 CG B:GLU166 4.2 16.6 1.0 N B:SER168 4.2 14.8 1.0 ND1 A:HIS46 4.2 16.4 1.0 CG A:HIS46 4.3 16.9 1.0 CG A:GLU42 4.3 15.1 1.0 O B:ALA165 4.6 16.4 1.0 CB A:GLU42 4.7 13.3 1.0 CB B:SER168 4.8 14.0 1.0 CB B:GLU166 4.8 17.6 1.0 CA B:SER168 4.8 14.0 1.0 C B:PRO167 4.9 15.3 1.0 CA B:PRO167 4.9 13.9 1.0 CA B:GLU166 4.9 17.7 1.0

Zinc binding site 2 out of 5 in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn270 b:28.3 occ:1.00 NE2 B:HIS23 2.1 20.2 1.0 OE2 B:GLU30 2.5 25.2 1.0 OE1 B:GLU30 2.8 29.4 1.0 CD2 B:HIS23 3.0 21.5 1.0 CD B:GLU30 3.0 24.9 1.0 CE1 B:HIS23 3.1 17.4 1.0 CD B:LYS20 4.0 17.5 1.0 NZ B:LYS20 4.1 19.2 1.0 CG B:HIS23 4.2 22.1 1.0 ND1 B:HIS23 4.2 21.3 1.0 O B:GLU30 4.3 25.3 1.0 CG B:GLU30 4.6 28.5 1.0 CE B:LYS20 4.7 18.6 1.0 CD1 B:LEU26 4.9 37.3 1.0

Zinc binding site 3 out of 5 in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn272 b:23.1 occ:1.00 NE2 B:HIS46 2.0 15.7 1.0 OE1 B:GLU42 2.1 23.1 1.0 CE1 B:HIS46 3.0 18.5 1.0 CD2 B:HIS46 3.0 18.0 1.0 CD B:GLU42 3.1 19.6 1.0 OE2 B:GLU42 3.4 18.5 1.0 CD2 B:LEU241 3.5 18.3 1.0 O B:HOH360 4.0 24.9 1.0 ND1 B:HIS46 4.1 18.4 1.0 CG B:HIS46 4.2 17.6 1.0 CG B:GLU42 4.4 17.4 1.0 CB B:GLU42 4.7 10.6 1.0 CG B:LEU241 5.0 17.8 1.0

Zinc binding site 4 out of 5 in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn271 b:29.9 occ:1.00 OD2 C:ASP65 2.2 22.0 1.0 OD1 C:ASP65 2.8 22.0 1.0 CG C:ASP65 2.8 21.2 1.0 CB C:ASP65 4.3 19.9 1.0 N C:ASP67 4.9 26.9 1.0

Zinc binding site 5 out of 5 in the Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) in Complex with Glutamate at 1.9 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn273 b:55.6 occ:1.00 OE1 C:GLU42 2.4 33.2 1.0 CE1 C:HIS46 2.5 41.9 1.0 CD C:GLU42 3.4 35.0 1.0 ND1 C:HIS46 3.4 37.5 1.0 OE1 C:GLN244 3.5 44.6 1.0 NE2 C:HIS46 3.5 41.8 1.0 CD2 C:LEU241 3.7 18.8 1.0 OE2 C:GLU42 3.8 37.7 1.0 NE2 C:GLN244 4.2 44.0 1.0 CD C:GLN244 4.3 44.2 1.0 CG C:GLU42 4.6 29.9 1.0 CG C:HIS46 4.7 36.6 1.0 CD2 C:HIS46 4.7 39.8 1.0 CD C:LYS45 4.7 38.5 1.0 CB C:GLU42 5.0 26.6 1.0

N.Armstrong, E.Gouaux. Mechanisms For Activation and Antagonism of An Ampa-Sensitive Glutamate Receptor: Crystal Structures of the GLUR2 Ligand Binding Core. Neuron V. 28 165 2000.
ISSN: ISSN 0896-6273
PubMed: 11086992
DOI: 10.1016/S0896-6273(00)00094-5