Atomistry » Zinc » PDB 1d5j-1dmy » 1dmy
Atomistry »
  Zinc »
    PDB 1d5j-1dmy »
      1dmy »

Zinc in PDB 1dmy: Complex Between Murine Mitochondrial Carbonic Anyhdrase V and the Transition State Analogue Acetazolamide

Enzymatic activity of Complex Between Murine Mitochondrial Carbonic Anyhdrase V and the Transition State Analogue Acetazolamide

All present enzymatic activity of Complex Between Murine Mitochondrial Carbonic Anyhdrase V and the Transition State Analogue Acetazolamide:
4.2.1.1;

Protein crystallography data

The structure of Complex Between Murine Mitochondrial Carbonic Anyhdrase V and the Transition State Analogue Acetazolamide, PDB code: 1dmy was solved by P.A.Boriack-Sjodin, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.45
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 48.690, 60.370, 60.440, 67.65, 75.26, 75.21
R / Rfree (%) 17 / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the Complex Between Murine Mitochondrial Carbonic Anyhdrase V and the Transition State Analogue Acetazolamide (pdb code 1dmy). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Complex Between Murine Mitochondrial Carbonic Anyhdrase V and the Transition State Analogue Acetazolamide, PDB code: 1dmy:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 1dmy

Go back to Zinc Binding Sites List in 1dmy
Zinc binding site 1 out of 2 in the Complex Between Murine Mitochondrial Carbonic Anyhdrase V and the Transition State Analogue Acetazolamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Complex Between Murine Mitochondrial Carbonic Anyhdrase V and the Transition State Analogue Acetazolamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn280

b:22.0
occ:1.00
N1 A:AZM400 1.9 21.7 1.0
NE2 A:HIS96 1.9 2.0 1.0
ND1 A:HIS119 2.0 4.2 1.0
NE2 A:HIS94 2.2 7.9 1.0
CD2 A:HIS94 2.7 5.4 1.0
O1 A:AZM400 2.8 25.0 1.0
CE1 A:HIS119 2.8 8.7 1.0
S1 A:AZM400 2.8 29.3 1.0
CD2 A:HIS96 2.9 3.9 1.0
CE1 A:HIS96 3.0 4.0 1.0
CG A:HIS119 3.2 10.9 1.0
CE1 A:HIS94 3.4 8.0 1.0
CB A:HIS119 3.6 10.0 1.0
CG A:HIS94 4.0 12.6 1.0
C1 A:AZM400 4.0 24.2 1.0
O2 A:AZM400 4.0 23.4 1.0
OG1 A:THR199 4.1 24.1 1.0
NE2 A:HIS119 4.1 10.8 1.0
CG A:HIS96 4.2 2.0 1.0
ND1 A:HIS96 4.2 2.0 1.0
CD2 A:HIS119 4.2 9.9 1.0
CE2 A:PHE65 4.3 12.1 1.0
ND1 A:HIS94 4.3 7.8 1.0
OE1 A:GLU106 4.4 29.5 1.0
CZ A:PHE65 4.8 14.2 1.0
N3 A:AZM400 4.9 23.2 1.0
CD A:GLU106 5.0 24.9 1.0

Zinc binding site 2 out of 2 in 1dmy

Go back to Zinc Binding Sites List in 1dmy
Zinc binding site 2 out of 2 in the Complex Between Murine Mitochondrial Carbonic Anyhdrase V and the Transition State Analogue Acetazolamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Complex Between Murine Mitochondrial Carbonic Anyhdrase V and the Transition State Analogue Acetazolamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn280

b:23.0
occ:1.00
N1 B:AZM900 1.8 11.8 1.0
NE2 B:HIS96 2.0 2.0 1.0
ND1 B:HIS119 2.0 8.4 1.0
NE2 B:HIS94 2.2 12.6 1.0
CD2 B:HIS94 2.7 12.8 1.0
CE1 B:HIS119 2.8 11.1 1.0
CD2 B:HIS96 2.9 2.0 1.0
S1 B:AZM900 3.0 23.5 1.0
CE1 B:HIS96 3.1 2.0 1.0
CG B:HIS119 3.2 13.4 1.0
CE1 B:HIS94 3.4 16.3 1.0
CB B:HIS119 3.6 12.4 1.0
O1 B:AZM900 3.6 24.4 1.0
CG B:HIS94 4.0 20.0 1.0
NE2 B:HIS119 4.0 9.1 1.0
OG1 B:THR199 4.1 22.2 1.0
O2 B:AZM900 4.1 18.2 1.0
C1 B:AZM900 4.1 18.8 1.0
CG B:HIS96 4.1 2.0 1.0
OE1 B:GLU106 4.2 15.0 1.0
ND1 B:HIS96 4.2 2.6 1.0
CD2 B:HIS119 4.2 15.1 1.0
CE2 B:PHE65 4.3 9.7 1.0
ND1 B:HIS94 4.3 22.0 1.0
N3 B:AZM900 4.7 18.2 1.0
CZ B:PHE65 4.8 13.7 1.0
CD B:GLU106 5.0 12.5 1.0

Reference:

P.A.Boriack-Sjodin, R.W.Heck, P.J.Laipis, D.N.Silverman, D.W.Christianson. Structure Determination of Murine Mitochondrial Carbonic Anhydrase V at 2.45-A Resolution: Implications For Catalytic Proton Transfer and Inhibitor Design. Proc.Natl.Acad.Sci.Usa V. 92 10949 1995.
ISSN: ISSN 0027-8424
PubMed: 7479916
DOI: 10.1073/PNAS.92.24.10949
Page generated: Wed Dec 16 02:47:20 2020

Last articles

Zn in 7M6U
Zn in 7NNG
Zn in 7NEE
Zn in 7NEU
Zn in 7M3K
Zn in 7KWD
Zn in 7KYH
Zn in 7KNG
Zn in 7KY2
Zn in 7KYF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy