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Zinc in PDB 1dmk: Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4- Amino-6-Phenyl-Tetrahydropteridine

Enzymatic activity of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4- Amino-6-Phenyl-Tetrahydropteridine

All present enzymatic activity of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4- Amino-6-Phenyl-Tetrahydropteridine:
1.14.13.39;

Protein crystallography data

The structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4- Amino-6-Phenyl-Tetrahydropteridine, PDB code: 1dmk was solved by P.Kotsonis, L.G.Frohlich, C.S.Raman, H.Li, M.Berg, R.Gerwig, V.Groehn, Y.Kang, N.Al-Masoudi, S.Taghavi-Moghadam, D.Mohr, U.Munch, J.Schnabel, P.Martasek, B.S.Masters, H.Strobel, T.Poulos, H.Matter, W.Pfleiderer, H.H.Schmidt, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.93 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 58.070, 106.110, 156.210, 90.00, 90.00, 90.00
R / Rfree (%) 22.5 / 26.4

Other elements in 1dmk:

The structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4- Amino-6-Phenyl-Tetrahydropteridine also contains other interesting chemical elements:

Arsenic (As) 2 atoms
Iron (Fe) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4- Amino-6-Phenyl-Tetrahydropteridine (pdb code 1dmk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4- Amino-6-Phenyl-Tetrahydropteridine, PDB code: 1dmk:

Zinc binding site 1 out of 1 in 1dmk

Go back to Zinc Binding Sites List in 1dmk
Zinc binding site 1 out of 1 in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4- Amino-6-Phenyl-Tetrahydropteridine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 4- Amino-6-Phenyl-Tetrahydropteridine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn900

b:38.0
occ:1.00
 SG B:CYS96 2.3 37.4 1.0
SG B:CYS101 2.3 38.7 1.0
SG A:CYS101 2.3 39.0 1.0
SG A:CYS96 2.4 37.2 1.0
CB B:CYS101 3.2 40.6 1.0
CB A:CYS101 3.3 43.3 1.0
CB A:CYS96 3.4 44.4 1.0
CB B:CYS96 3.4 43.7 1.0
CA A:CYS101 3.7 44.6 1.0
CA B:CYS101 3.8 41.2 1.0
N A:GLY103 4.0 41.3 1.0
N A:LEU102 4.1 43.3 1.0
N B:GLY103 4.2 38.7 1.0
CA A:GLY103 4.3 40.5 1.0
C A:CYS101 4.3 43.7 1.0
N B:LEU102 4.4 40.6 1.0
CA B:GLY103 4.4 37.1 1.0
C B:CYS101 4.4 40.8 1.0
CA A:CYS96 4.8 46.2 1.0
CA B:CYS96 4.8 44.4 1.0
O B:HOH2887 4.9 44.1 1.0
N A:CYS101 4.9 47.6 1.0
C A:LEU102 5.0 42.1 1.0

Reference:

P.Kotsonis, L.G.Frohlich, C.S.Raman, H.Li, M.Berg, R.Gerwig, V.Groehn, Y.Kang, N.Al-Masoudi, S.Taghavi-Moghadam, D.Mohr, U.Munch, J.Schnabel, P.Martasek, B.S.Masters, H.Strobel, T.Poulos, H.Matter, W.Pfleiderer, H.H.Schmidt. Structural Basis For Pterin Antagonism in Nitric-Oxide Synthase. Development of Novel 4-Oxo-Pteridine Antagonists of (6R)-5,6,7,8-Tetrahydrobiopterin J.Biol.Chem. V. 276 49133 2001.
ISSN: ISSN 0021-9258
PubMed: 11590164
DOI: 10.1074/JBC.M011469200
Page generated: Sat Oct 12 23:45:31 2024

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