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Zinc in PDB 1d0o: Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 3- Bromo-7-Nitroindazole (H4B Present)

Enzymatic activity of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 3- Bromo-7-Nitroindazole (H4B Present)

All present enzymatic activity of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 3- Bromo-7-Nitroindazole (H4B Present):
1.14.13.39;

Protein crystallography data

The structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 3- Bromo-7-Nitroindazole (H4B Present), PDB code: 1d0o was solved by C.S.Raman, H.Li, P.Martasek, G.J.Southan, B.S.S.Masters, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 1.95
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 57.590, 106.060, 155.780, 90.00, 90.00, 90.00
R / Rfree (%) 20 / 24.7

Other elements in 1d0o:

The structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 3- Bromo-7-Nitroindazole (H4B Present) also contains other interesting chemical elements:

Bromine (Br) 4 atoms
Arsenic (As) 2 atoms
Iron (Fe) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 3- Bromo-7-Nitroindazole (H4B Present) (pdb code 1d0o). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 3- Bromo-7-Nitroindazole (H4B Present), PDB code: 1d0o:

Zinc binding site 1 out of 1 in 1d0o

Go back to Zinc Binding Sites List in 1d0o
Zinc binding site 1 out of 1 in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 3- Bromo-7-Nitroindazole (H4B Present)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with 3- Bromo-7-Nitroindazole (H4B Present) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn900

b:28.1
occ:1.00
SG B:CYS101 2.3 32.9 1.0
SG B:CYS96 2.3 26.9 1.0
SG A:CYS96 2.3 29.2 1.0
SG A:CYS101 2.3 30.4 1.0
CB B:CYS101 3.0 30.7 1.0
CB A:CYS101 3.3 29.0 1.0
CB A:CYS96 3.5 30.0 1.0
CB B:CYS96 3.5 26.6 1.0
CA B:CYS101 3.7 31.3 1.0
CA A:CYS101 3.7 28.8 1.0
N A:GLY103 4.1 31.7 1.0
N B:GLY103 4.2 29.9 1.0
N A:LEU102 4.2 30.9 1.0
N B:LEU102 4.3 31.2 1.0
C B:CYS101 4.3 31.2 1.0
C A:CYS101 4.4 29.1 1.0
CA A:GLY103 4.4 32.5 1.0
CA B:GLY103 4.5 27.7 1.0
O A:HOH1054 4.8 46.5 1.0
O B:HOH1032 4.8 41.5 1.0
CA A:CYS96 4.9 34.6 1.0
CA B:CYS96 4.9 32.0 1.0
N B:CYS101 4.9 32.1 1.0
N A:CYS101 5.0 30.1 1.0

Reference:

C.S.Raman, H.Li, P.Martasek, G.Southan, B.S.Masters, T.L.Poulos. Crystal Structure of Nitric Oxide Synthase Bound to Nitro Indazole Reveals A Novel Inactivation Mechanism. Biochemistry V. 40 13448 2001.
ISSN: ISSN 0006-2960
PubMed: 11695891
DOI: 10.1021/BI010957U
Page generated: Mon Jan 25 16:08:12 2021

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