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Zinc in PDB 1czm: Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I

Enzymatic activity of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I

All present enzymatic activity of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I:
4.2.1.1;

Protein crystallography data

The structure of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I, PDB code: 1czm was solved by S.Chakravarty, K.K.Kannan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 81.850, 75.310, 37.760, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Other elements in 1czm:

The structure of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I also contains other interesting chemical elements:

Mercury (Hg) 5 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I (pdb code 1czm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I, PDB code: 1czm:

Zinc binding site 1 out of 1 in 1czm

Go back to Zinc Binding Sites List in 1czm
Zinc binding site 1 out of 1 in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn261

b:7.8
occ:0.97
 N1 A:AAS262 1.9 7.0 1.0
ND1 A:HIS119 2.0 2.2 1.0
NE2 A:HIS94 2.0 5.2 1.0
NE2 A:HIS96 2.1 5.8 1.0
CE1 A:HIS119 2.8 2.3 1.0
CD2 A:HIS94 3.0 5.9 1.0
S1 A:AAS262 3.0 8.1 0.9
O1 A:AAS262 3.0 8.0 0.8
CG A:HIS119 3.1 2.9 1.0
CE1 A:HIS94 3.1 4.1 1.0
CD2 A:HIS96 3.1 5.4 1.0
CE1 A:HIS96 3.1 5.7 1.0
CB A:HIS119 3.6 2.1 1.0
C1 A:AAS262 4.0 8.0 1.0
NE2 A:HIS119 4.0 2.6 1.0
O2 A:AAS262 4.1 6.9 0.8
OG1 A:THR199 4.1 3.7 1.0
CD2 A:HIS119 4.2 2.2 1.0
CG A:HIS94 4.2 5.2 1.0
ND1 A:HIS94 4.2 4.9 1.0
OE1 A:GLU106 4.2 8.7 1.0
ND1 A:HIS96 4.2 5.5 1.0
CG A:HIS96 4.3 4.5 1.0
O A:HOH274 4.5 9.6 1.0
C6 A:AAS262 4.6 8.4 0.5
C2 A:AAS262 4.7 8.3 0.4
O A:HOH368 5.0 9.7 0.7

Reference:

S.Chakravarty, K.K.Kannan. Drug-Protein Interactions. Refined Structures of Three Sulfonamide Drug Complexes of Human Carbonic Anhydrase I Enzyme. J.Mol.Biol. V. 243 298 1994.
ISSN: ISSN 0022-2836
PubMed: 7932756
DOI: 10.1006/JMBI.1994.1655
Page generated: Sat Oct 12 23:23:25 2024

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