Zinc in PDB 1cp6: 1-Butaneboronic Acid Binding to Aeromonas Proteolytica Aminopeptidase

All present enzymatic activity of 1-Butaneboronic Acid Binding to Aeromonas Proteolytica Aminopeptidase:
3.4.11.10;

The structure of 1-Butaneboronic Acid Binding to Aeromonas Proteolytica Aminopeptidase, PDB code: 1cp6 was solved by C.C.Depaola, B.Bennett, R.C.Holz, D.Ringe, G.A.Petsko, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	10.00 / 1.90
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	109.200, 109.200, 97.700, 90.00, 90.00, 120.00
R / Rfree (%)	19.3 / 22.9

The binding sites of Zinc atom in the 1-Butaneboronic Acid Binding to Aeromonas Proteolytica Aminopeptidase (pdb code 1cp6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the 1-Butaneboronic Acid Binding to Aeromonas Proteolytica Aminopeptidase, PDB code: 1cp6:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the 1-Butaneboronic Acid Binding to Aeromonas Proteolytica Aminopeptidase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of 1-Butaneboronic Acid Binding to Aeromonas Proteolytica Aminopeptidase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:12.6 occ:1.00 OD2 A:ASP117 2.2 4.8 1.0 OE2 A:GLU152 2.2 5.2 1.0 NE2 A:HIS256 2.2 10.3 1.0 O15 A:BUB601 2.5 22.9 1.0 OE1 A:GLU152 2.6 6.5 1.0 O16 A:BUB601 2.7 22.1 1.0 CD A:GLU152 2.7 2.0 1.0 B12 A:BUB601 3.0 22.5 1.0 CG A:ASP117 3.1 5.6 1.0 CE1 A:HIS256 3.2 9.3 1.0 CD2 A:HIS256 3.2 7.8 1.0 OD1 A:ASP117 3.3 2.9 1.0 ZN A:ZN502 3.3 11.3 1.0 O A:HOH644 4.2 4.1 1.0 CG A:GLU152 4.2 2.0 1.0 OE1 A:GLU151 4.3 5.7 1.0 O A:HOH671 4.3 23.3 1.0 ND1 A:HIS256 4.3 9.7 1.0 O A:HOH654 4.3 25.1 1.0 CG A:HIS256 4.4 10.0 1.0 CB A:ASP117 4.5 2.6 1.0 C9 A:BUB601 4.5 20.8 1.0 NE2 A:HIS97 4.6 3.9 1.0 CD1 A:ILE255 4.6 6.1 1.0 CE1 A:HIS97 4.8 3.3 1.0

Zinc binding site 2 out of 2 in the 1-Butaneboronic Acid Binding to Aeromonas Proteolytica Aminopeptidase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of 1-Butaneboronic Acid Binding to Aeromonas Proteolytica Aminopeptidase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:11.3 occ:1.00 OD1 A:ASP117 2.1 2.9 1.0 OD1 A:ASP179 2.2 9.2 1.0 NE2 A:HIS97 2.2 3.9 1.0 OD2 A:ASP179 2.5 9.3 1.0 CG A:ASP179 2.7 8.6 1.0 O16 A:BUB601 3.0 22.1 1.0 CG A:ASP117 3.1 5.6 1.0 CD2 A:HIS97 3.2 7.8 1.0 CE1 A:HIS97 3.2 3.3 1.0 ZN A:ZN501 3.3 12.6 1.0 OD2 A:ASP117 3.4 4.8 1.0 OE1 A:GLU151 3.6 5.7 1.0 OE2 A:GLU152 3.7 5.2 1.0 B12 A:BUB601 3.7 22.5 1.0 CB A:ASP118 4.0 3.0 1.0 CB A:ASP179 4.2 5.2 1.0 CD A:GLU151 4.2 10.1 1.0 CG A:HIS97 4.3 5.3 1.0 ND1 A:HIS97 4.3 3.5 1.0 CB A:ASP117 4.4 2.6 1.0 CD A:GLU152 4.4 2.0 1.0 O15 A:BUB601 4.4 22.9 1.0 OE2 A:GLU151 4.6 12.0 1.0 CA A:ASP117 4.6 4.2 1.0 OE1 A:GLU152 4.7 6.5 1.0 CG A:ASP118 4.7 4.2 1.0 C A:ASP117 4.7 4.6 1.0 O A:HOH654 4.8 25.1 1.0 OG A:SER228 4.9 9.8 1.0 N A:ASP118 4.9 2.9 1.0 CA A:ASP179 4.9 5.8 1.0 CA A:ASP118 4.9 3.6 1.0 CG A:MET180 4.9 3.8 1.0 OD2 A:ASP118 5.0 3.6 1.0

C.C.De Paola, B.Bennett, R.C.Holz, D.Ringe, G.A.Petsko. 1-Butaneboronic Acid Binding to Aeromonas Proteolytica Aminopeptidase: A Case of Arrested Development. Biochemistry V. 38 9048 1999.
ISSN: ISSN 0006-2960
PubMed: 10413478
DOI: 10.1021/BI9900572