Zinc in PDB 1c8m: Refined Crystal Structure of Human Rhinovirus 16 Complexed with VP63843 (Pleconaril), An Anti-Picornaviral Drug Currently in Clinical Trials

The structure of Refined Crystal Structure of Human Rhinovirus 16 Complexed with VP63843 (Pleconaril), An Anti-Picornaviral Drug Currently in Clinical Trials, PDB code: 1c8m was solved by S.Chakravarty, C.M.Bator, D.C.Pevear, G.D.Diana, M.G.Rossmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.80
Space group	P 2 21 21
Cell size a, b, c (Å), α, β, γ (°)	360.300, 343.330, 332.630, 90.00, 90.00, 90.00
R / Rfree (%)	21.9 / 22.6

The structure of Refined Crystal Structure of Human Rhinovirus 16 Complexed with VP63843 (Pleconaril), An Anti-Picornaviral Drug Currently in Clinical Trials also contains other interesting chemical elements:

Fluorine

(F)

3 atoms

The binding sites of Zinc atom in the Refined Crystal Structure of Human Rhinovirus 16 Complexed with VP63843 (Pleconaril), An Anti-Picornaviral Drug Currently in Clinical Trials (pdb code 1c8m). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Refined Crystal Structure of Human Rhinovirus 16 Complexed with VP63843 (Pleconaril), An Anti-Picornaviral Drug Currently in Clinical Trials, PDB code: 1c8m:

Zinc binding site 1 out of 1 in the Refined Crystal Structure of Human Rhinovirus 16 Complexed with VP63843 (Pleconaril), An Anti-Picornaviral Drug Currently in Clinical Trials


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Refined Crystal Structure of Human Rhinovirus 16 Complexed with VP63843 (Pleconaril), An Anti-Picornaviral Drug Currently in Clinical Trials within 5.0Å range: probe atom residue distance (Å) B Occ 1:Zn6000 b:18.3 occ:1.00 NE2 1:HIS134 2.8 47.6 1.0 CE1 1:HIS134 3.5 47.6 1.0 CD2 1:HIS134 3.9 46.3 1.0 ND1 1:HIS134 4.7 45.3 1.0 CG 1:HIS134 4.9 43.4 1.0

S.Chakravarty, C.M.Bator, D.C.Pevear, G.D.Diana, M.G.Rossmann. The Refined Structure of A Picornavirus Inhibitor Currently in Clinical Trials, When Complexed with Human Rhinovirus 16 To Be Published.