Atomistry » Zinc » PDB 1aye-1biw » 1azm
Atomistry »
  Zinc »
    PDB 1aye-1biw »
      1azm »

Zinc in PDB 1azm: Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I

Enzymatic activity of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I

All present enzymatic activity of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I:
4.2.1.1;

Protein crystallography data

The structure of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I, PDB code: 1azm was solved by S.Chakravarty, K.K.Kannan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 81.850, 75.310, 37.760, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I (pdb code 1azm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I, PDB code: 1azm:

Zinc binding site 1 out of 1 in 1azm

Go back to Zinc Binding Sites List in 1azm
Zinc binding site 1 out of 1 in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn261

b:7.5
occ:1.00
 N1 A:AZM262 2.0 7.4 0.9
ND1 A:HIS119 2.0 2.1 1.0
NE2 A:HIS94 2.0 6.0 1.0
NE2 A:HIS96 2.2 4.6 1.0
CD2 A:HIS94 2.9 8.0 1.0
CE1 A:HIS119 2.9 3.1 1.0
CD2 A:HIS96 3.0 5.5 1.0
CG A:HIS119 3.1 3.9 1.0
O1 A:AZM262 3.2 5.3 1.0
S1 A:AZM262 3.2 7.9 1.0
CE1 A:HIS94 3.2 7.4 1.0
CE1 A:HIS96 3.2 5.1 1.0
CB A:HIS119 3.6 3.0 1.0
O2 A:AZM262 4.0 7.1 0.6
OG1 A:THR199 4.0 4.8 1.0
NE2 A:HIS119 4.1 2.0 1.0
CG A:HIS94 4.1 7.7 1.0
CD2 A:HIS119 4.2 2.5 1.0
CG A:HIS96 4.2 6.2 1.0
ND1 A:HIS94 4.2 5.5 1.0
OE1 A:GLU106 4.2 11.0 1.0
ND1 A:HIS96 4.3 7.0 1.0
C1 A:AZM262 4.4 8.6 1.0
O A:HOH277 4.7 12.1 1.0
O A:HOH272 4.8 7.5 1.0
N3 A:AZM262 5.0 9.1 0.7

Reference:

S.Chakravarty, K.K.Kannan. Drug-Protein Interactions. Refined Structures of Three Sulfonamide Drug Complexes of Human Carbonic Anhydrase I Enzyme. J.Mol.Biol. V. 243 298 1994.
ISSN: ISSN 0022-2836
PubMed: 7932756
DOI: 10.1006/JMBI.1994.1655
Page generated: Sat Oct 12 22:20:30 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy