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Zinc in PDB 1azm: Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I

Enzymatic activity of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I

All present enzymatic activity of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I:
4.2.1.1;

Protein crystallography data

The structure of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I, PDB code: 1azm was solved by S.Chakravarty, K.K.Kannan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 81.850, 75.310, 37.760, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I (pdb code 1azm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I, PDB code: 1azm:

Zinc binding site 1 out of 1 in 1azm

Go back to Zinc Binding Sites List in 1azm
Zinc binding site 1 out of 1 in the Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Drug-Protein Interactions: Structure of Sulfonamide Drug Complexed with Human Carbonic Anhydrase I within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn261

b:7.5
occ:1.00
 N1 A:AZM262 2.0 7.4 0.9
ND1 A:HIS119 2.0 2.1 1.0
NE2 A:HIS94 2.0 6.0 1.0
NE2 A:HIS96 2.2 4.6 1.0
CD2 A:HIS94 2.9 8.0 1.0
CE1 A:HIS119 2.9 3.1 1.0
CD2 A:HIS96 3.0 5.5 1.0
CG A:HIS119 3.1 3.9 1.0
O1 A:AZM262 3.2 5.3 1.0
S1 A:AZM262 3.2 7.9 1.0
CE1 A:HIS94 3.2 7.4 1.0
CE1 A:HIS96 3.2 5.1 1.0
CB A:HIS119 3.6 3.0 1.0
O2 A:AZM262 4.0 7.1 0.6
OG1 A:THR199 4.0 4.8 1.0
NE2 A:HIS119 4.1 2.0 1.0
CG A:HIS94 4.1 7.7 1.0
CD2 A:HIS119 4.2 2.5 1.0
CG A:HIS96 4.2 6.2 1.0
ND1 A:HIS94 4.2 5.5 1.0
OE1 A:GLU106 4.2 11.0 1.0
ND1 A:HIS96 4.3 7.0 1.0
C1 A:AZM262 4.4 8.6 1.0
O A:HOH277 4.7 12.1 1.0
O A:HOH272 4.8 7.5 1.0
N3 A:AZM262 5.0 9.1 0.7

Reference:

S.Chakravarty, K.K.Kannan. Drug-Protein Interactions. Refined Structures of Three Sulfonamide Drug Complexes of Human Carbonic Anhydrase I Enzyme. J.Mol.Biol. V. 243 298 1994.
ISSN: ISSN 0022-2836
PubMed: 7932756
DOI: 10.1006/JMBI.1994.1655
Page generated: Sat Oct 12 22:20:30 2024

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