Atomistry » Zinc » PDB 1adf-1axg » 1adg
Atomistry »
  Zinc »
    PDB 1adf-1axg »
      1adg »

Zinc in PDB 1adg: Crystallographic Studies of Two Alcohol Dehydrogenase-Bound Analogs of Thiazole-4-Carboxamide Adenine Dinucleotide (Tad), the Active Anabolite of the Antitumor Agent Tiazofurin

Enzymatic activity of Crystallographic Studies of Two Alcohol Dehydrogenase-Bound Analogs of Thiazole-4-Carboxamide Adenine Dinucleotide (Tad), the Active Anabolite of the Antitumor Agent Tiazofurin

All present enzymatic activity of Crystallographic Studies of Two Alcohol Dehydrogenase-Bound Analogs of Thiazole-4-Carboxamide Adenine Dinucleotide (Tad), the Active Anabolite of the Antitumor Agent Tiazofurin:
1.1.1.1;

Protein crystallography data

The structure of Crystallographic Studies of Two Alcohol Dehydrogenase-Bound Analogs of Thiazole-4-Carboxamide Adenine Dinucleotide (Tad), the Active Anabolite of the Antitumor Agent Tiazofurin, PDB code: 1adg was solved by H.Li, W.A.Hallows, J.S.Punzi, V.E.Marquez, H.L.Carrell, K.W.Pankiewicz, K.A.Watanabe, B.M.Goldstein, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 2.70
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 56.300, 75.200, 182.300, 90.00, 90.00, 90.00
R / Rfree (%) 16 / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystallographic Studies of Two Alcohol Dehydrogenase-Bound Analogs of Thiazole-4-Carboxamide Adenine Dinucleotide (Tad), the Active Anabolite of the Antitumor Agent Tiazofurin (pdb code 1adg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystallographic Studies of Two Alcohol Dehydrogenase-Bound Analogs of Thiazole-4-Carboxamide Adenine Dinucleotide (Tad), the Active Anabolite of the Antitumor Agent Tiazofurin, PDB code: 1adg:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 1adg

Go back to Zinc Binding Sites List in 1adg
Zinc binding site 1 out of 2 in the Crystallographic Studies of Two Alcohol Dehydrogenase-Bound Analogs of Thiazole-4-Carboxamide Adenine Dinucleotide (Tad), the Active Anabolite of the Antitumor Agent Tiazofurin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystallographic Studies of Two Alcohol Dehydrogenase-Bound Analogs of Thiazole-4-Carboxamide Adenine Dinucleotide (Tad), the Active Anabolite of the Antitumor Agent Tiazofurin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn376

b:13.9
occ:1.00
 O A:HOH388 1.6 2.5 1.0
NE2 A:HIS67 2.0 7.9 1.0
SG A:CYS174 2.0 4.6 1.0
H1 A:HOH388 2.4 15.0 1.0
H2 A:HOH388 2.5 15.0 1.0
SG A:CYS46 2.7 5.9 1.0
CD2 A:HIS67 2.9 6.0 1.0
CE1 A:HIS67 2.9 7.1 1.0
CB A:CYS174 3.3 8.2 1.0
OG A:SER48 3.4 10.0 1.0
ND1 A:HIS67 4.0 6.7 1.0
CG A:HIS67 4.0 6.6 1.0
CB A:CYS46 4.1 8.3 1.0
HG A:SER48 4.2 15.0 1.0
O A:HOH391 4.3 4.6 1.0
CB A:SER48 4.3 9.2 1.0
HH22 A:ARG369 4.4 15.0 1.0
H A:SER48 4.5 15.0 1.0
O A:HOH379 4.5 19.5 1.0
CA A:CYS174 4.6 6.2 1.0
H A:GLY175 4.6 15.0 1.0
N A:GLY175 4.8 6.8 1.0
H1 A:HOH391 4.8 15.0 1.0
HD1 A:HIS67 4.9 15.0 1.0
H2 A:HOH391 4.9 15.0 1.0
C A:CYS174 4.9 6.3 1.0
CE2 A:PHE93 5.0 7.9 1.0

Zinc binding site 2 out of 2 in 1adg

Go back to Zinc Binding Sites List in 1adg
Zinc binding site 2 out of 2 in the Crystallographic Studies of Two Alcohol Dehydrogenase-Bound Analogs of Thiazole-4-Carboxamide Adenine Dinucleotide (Tad), the Active Anabolite of the Antitumor Agent Tiazofurin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystallographic Studies of Two Alcohol Dehydrogenase-Bound Analogs of Thiazole-4-Carboxamide Adenine Dinucleotide (Tad), the Active Anabolite of the Antitumor Agent Tiazofurin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn377

b:17.5
occ:1.00
 SG A:CYS97 2.3 13.3 1.0
SG A:CYS100 2.3 10.0 1.0
SG A:CYS103 2.5 7.9 1.0
SG A:CYS111 2.6 8.7 1.0
CB A:CYS97 3.4 8.7 1.0
H A:CYS97 3.4 15.0 1.0
H A:CYS100 3.5 15.0 1.0
N A:CYS97 3.6 8.1 1.0
CB A:CYS111 3.7 7.3 1.0
CB A:CYS100 3.7 6.7 1.0
CB A:CYS103 3.7 8.2 1.0
CA A:CYS97 3.9 8.1 1.0
N A:CYS100 4.0 6.6 1.0
CA A:CYS111 4.0 7.9 1.0
H A:CYS103 4.1 15.0 1.0
N A:GLY98 4.2 8.0 1.0
C A:CYS97 4.2 7.3 1.0
N A:LEU112 4.2 7.0 1.0
H A:GLY98 4.2 15.0 1.0
H A:LEU112 4.2 15.0 1.0
H A:LYS113 4.3 15.0 1.0
CA A:CYS100 4.4 6.6 1.0
H A:LYS99 4.4 15.0 1.0
C A:CYS111 4.4 8.2 1.0
N A:CYS103 4.5 7.6 1.0
N A:LYS99 4.5 10.0 1.0
CA A:CYS103 4.7 7.5 1.0
C A:GLN96 4.7 6.0 1.0
O A:CYS100 4.7 9.3 1.0
N A:LYS113 4.8 5.2 1.0
O A:CYS97 4.9 7.7 1.0
C A:CYS100 4.9 7.8 1.0
C A:GLY98 5.0 9.6 1.0
CA A:LEU112 5.0 7.5 1.0
O A:HOH400 5.0 2.6 1.0

Reference:

H.Li, W.H.Hallows, J.S.Punzi, V.E.Marquez, H.L.Carrell, K.W.Pankiewicz, K.A.Watanabe, B.M.Goldstein. Crystallographic Studies of Two Alcohol Dehydrogenase-Bound Analogues of Thiazole-4-Carboxamide Adenine Dinucleotide (Tad), the Active Anabolite of the Antitumor Agent Tiazofurin. Biochemistry V. 33 23 1994.
ISSN: ISSN 0006-2960
PubMed: 8286346
DOI: 10.1021/BI00167A004
Page generated: Sat Oct 12 21:59:14 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy