Atomistry » Zinc » PDB 12ca-1add » 1adb
Atomistry »
  Zinc »
    PDB 12ca-1add »
      1adb »

Zinc in PDB 1adb: Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes

Enzymatic activity of Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes

All present enzymatic activity of Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes:
1.1.1.1;

Protein crystallography data

The structure of Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes, PDB code: 1adb was solved by H.Li, W.A.Hallows, J.S.Punzi, K.W.Pankiewicz, K.A.Watanabe, B.M.Goldstein, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 2.40
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 52.100, 44.700, 93.500, 103.30, 87.90, 70.40
R / Rfree (%) 18 / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes (pdb code 1adb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes, PDB code: 1adb:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 1adb

Go back to Zinc Binding Sites List in 1adb
Zinc binding site 1 out of 4 in the Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn375

b:14.2
occ:1.00
NE2 A:HIS67 2.0 3.6 1.0
SG A:CYS46 2.2 2.8 1.0
SG A:CYS174 2.2 9.7 1.0
N5N A:CND377 2.2 2.2 1.0
CE1 A:HIS67 2.9 2.1 1.0
CD2 A:HIS67 3.1 2.1 1.0
C6N A:CND377 3.1 2.5 1.0
C4N A:CND377 3.2 2.5 1.0
CB A:CYS46 3.3 2.1 1.0
CB A:CYS174 3.6 9.4 1.0
ND1 A:HIS67 4.1 2.2 1.0
H A:SER48 4.2 15.0 1.0
CG A:HIS67 4.2 2.0 1.0
HH21 A:ARG369 4.3 15.0 1.0
O A:EOH378 4.3 8.1 1.0
C1N A:CND377 4.4 2.0 1.0
HH22 A:ARG369 4.4 15.0 1.0
CB A:SER48 4.4 2.2 1.0
C3N A:CND377 4.5 3.7 1.0
OG A:SER48 4.5 2.7 1.0
NH2 A:ARG369 4.6 2.2 1.0
H A:GLY175 4.6 15.0 1.0
OE1 A:GLU68 4.7 15.0 1.0
CA A:CYS46 4.7 4.4 1.0
N A:GLY175 4.8 7.2 1.0
H A:ARG47 4.9 15.0 1.0
CA A:CYS174 4.9 6.1 1.0
HD1 A:HIS67 5.0 15.0 1.0
C2N A:CND377 5.0 4.0 1.0

Zinc binding site 2 out of 4 in 1adb

Go back to Zinc Binding Sites List in 1adb
Zinc binding site 2 out of 4 in the Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn376

b:19.0
occ:1.00
SG A:CYS97 2.0 20.3 1.0
SG A:CYS111 2.2 5.0 1.0
SG A:CYS103 2.2 14.8 1.0
SG A:CYS100 2.4 16.3 1.0
H A:CYS97 2.9 15.0 1.0
H A:CYS100 3.3 15.0 1.0
CB A:CYS111 3.4 14.0 1.0
H A:GLY98 3.4 15.0 1.0
CB A:CYS97 3.4 11.3 1.0
H A:LEU112 3.4 15.0 1.0
N A:CYS97 3.5 10.6 1.0
CB A:CYS103 3.5 14.2 1.0
CB A:CYS100 3.5 16.3 1.0
H A:CYS103 3.8 15.0 1.0
CA A:CYS97 3.9 14.2 1.0
CA A:CYS111 3.9 17.2 1.0
N A:GLY98 3.9 14.5 1.0
N A:CYS100 3.9 17.3 1.0
N A:LEU112 4.0 16.6 1.0
H A:LYS99 4.0 15.0 1.0
H A:LYS113 4.1 15.0 1.0
CA A:CYS100 4.2 14.9 1.0
C A:CYS97 4.3 14.6 1.0
N A:CYS103 4.4 19.9 1.0
C A:CYS111 4.4 15.7 1.0
CA A:CYS103 4.5 19.1 1.0
C A:GLN96 4.5 10.1 1.0
HZ1 A:LYS113 4.5 15.0 1.0
N A:LYS99 4.5 22.0 1.0
CG A:LYS113 4.7 18.1 1.0
O A:CYS100 4.8 19.2 1.0
CA A:GLN96 4.8 5.8 1.0
N A:LYS113 4.8 12.3 1.0
C A:CYS100 4.8 16.9 1.0
CA A:GLY98 4.9 16.4 1.0
CA A:LEU112 5.0 16.0 1.0

Zinc binding site 3 out of 4 in 1adb

Go back to Zinc Binding Sites List in 1adb
Zinc binding site 3 out of 4 in the Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn375

b:16.1
occ:1.00
NE2 B:HIS67 2.1 13.9 1.0
N5N B:CND377 2.2 10.1 1.0
SG B:CYS174 2.3 10.6 1.0
SG B:CYS46 2.4 24.5 1.0
CE1 B:HIS67 2.9 10.3 1.0
C6N B:CND377 3.2 8.3 1.0
C4N B:CND377 3.2 10.9 1.0
CD2 B:HIS67 3.2 4.2 1.0
CB B:CYS46 3.5 20.7 1.0
OG B:SER48 3.6 19.8 1.0
CB B:CYS174 3.8 2.8 1.0
O B:EOH378 4.0 15.1 1.0
ND1 B:HIS67 4.1 7.5 1.0
H B:SER48 4.2 15.0 1.0
HH21 B:ARG369 4.2 15.0 1.0
CB B:SER48 4.2 13.8 1.0
HH22 B:ARG369 4.3 15.0 1.0
CG B:HIS67 4.3 8.6 1.0
OE1 B:GLU68 4.5 19.6 1.0
HG B:SER48 4.5 15.0 1.0
C1N B:CND377 4.5 10.1 1.0
C3N B:CND377 4.5 14.7 1.0
H B:GLY175 4.5 15.0 1.0
NH2 B:ARG369 4.6 23.1 1.0
N B:GLY175 4.9 11.8 1.0
CA B:CYS46 4.9 14.5 1.0
HD1 B:HIS67 5.0 15.0 1.0
N B:SER48 5.0 11.8 1.0

Zinc binding site 4 out of 4 in 1adb

Go back to Zinc Binding Sites List in 1adb
Zinc binding site 4 out of 4 in the Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn376

b:16.6
occ:1.00
SG B:CYS100 2.0 20.3 1.0
SG B:CYS97 2.2 18.4 1.0
SG B:CYS103 2.3 2.2 1.0
SG B:CYS111 2.6 18.7 1.0
H B:CYS97 3.1 15.0 1.0
H B:CYS100 3.2 15.0 1.0
CB B:CYS100 3.3 16.1 1.0
H B:GLY98 3.4 15.0 1.0
CB B:CYS103 3.5 12.3 1.0
H B:LEU112 3.5 15.0 1.0
N B:CYS97 3.6 16.4 1.0
CB B:CYS111 3.6 14.8 1.0
CB B:CYS97 3.6 15.9 1.0
H B:CYS103 3.7 15.0 1.0
H B:LYS99 3.9 15.0 1.0
N B:CYS100 3.9 19.2 1.0
H B:LYS113 3.9 15.0 1.0
N B:GLY98 3.9 22.5 1.0
N B:LEU112 4.0 13.0 1.0
CA B:CYS111 4.0 10.2 1.0
CA B:CYS97 4.0 18.3 1.0
CA B:CYS100 4.2 17.7 1.0
CG B:LYS113 4.2 30.0 1.0
N B:CYS103 4.3 13.6 1.0
C B:CYS97 4.4 20.9 1.0
C B:CYS111 4.4 12.4 1.0
CA B:CYS103 4.5 12.6 1.0
N B:LYS99 4.5 25.1 1.0
C B:GLN96 4.5 12.8 1.0
N B:LYS113 4.6 16.6 1.0
CA B:GLN96 4.7 9.3 1.0
O B:CYS100 4.8 13.8 1.0
C B:CYS100 4.8 15.6 1.0
CA B:GLY98 4.9 24.3 1.0
CA B:LEU112 4.9 13.0 1.0
CB B:LYS113 5.0 21.8 1.0
C B:LYS99 5.0 23.2 1.0

Reference:

H.Li, W.H.Hallows, J.S.Punzi, K.W.Pankiewicz, K.A.Watanabe, B.M.Goldstein. Crystallographic Studies of Isosteric Nad Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes. Biochemistry V. 33 11734 1994.
ISSN: ISSN 0006-2960
PubMed: 7918390
DOI: 10.1021/BI00205A009
Page generated: Wed Dec 16 02:44:33 2020

Last articles

Zn in 7L3L
Zn in 7KSO
Zn in 7KSR
Zn in 7KTP
Zn in 7LMM
Zn in 7LMK
Zn in 7LLZ
Zn in 7LLF
Zn in 7L0N
Zn in 7LBR
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy