Zinc in PDB 1a1q: Hepatitis C Virus NS3 Proteinase

The structure of Hepatitis C Virus NS3 Proteinase, PDB code: 1a1q was solved by R.A.Love, H.E.Parge, J.A.Wickersham, Z.Hostomsky, N.Habuka, E.W.Moomaw, T.Adachi, Z.Hostomska, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 2.40
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	133.000, 133.000, 223.000, 90.00, 90.00, 120.00
R / Rfree (%)	22.5 / 32

The binding sites of Zinc atom in the Hepatitis C Virus NS3 Proteinase (pdb code 1a1q). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Hepatitis C Virus NS3 Proteinase, PDB code: 1a1q:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Hepatitis C Virus NS3 Proteinase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Hepatitis C Virus NS3 Proteinase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn901 b:27.3 occ:1.00 CA A:CYS97 4.1 18.1 1.0 CA A:CYS99 4.5 25.9 1.0 CA A:THR98 4.9 23.5 1.0 CA A:CYS145 5.0 8.8 1.0

Zinc binding site 2 out of 3 in the Hepatitis C Virus NS3 Proteinase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Hepatitis C Virus NS3 Proteinase within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn901 b:27.2 occ:1.00 CA B:CYS97 4.0 22.4 1.0 CA B:CYS99 4.4 29.3 1.0 CA B:CYS145 4.6 13.2 1.0

Zinc binding site 3 out of 3 in the Hepatitis C Virus NS3 Proteinase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Hepatitis C Virus NS3 Proteinase within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn901 b:29.5 occ:1.00 CA C:CYS97 3.7 23.6 1.0 CA C:CYS99 4.4 29.2 1.0 CA C:CYS145 4.6 12.2 1.0 CA C:THR98 4.9 30.9 1.0

R.A.Love, H.E.Parge, J.A.Wickersham, Z.Hostomsky, N.Habuka, E.W.Moomaw, T.Adachi, Z.Hostomska. The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals A Trypsin-Like Fold and A Structural Zinc Binding Site. Cell(Cambridge,Mass.) V. 87 331 1996.
ISSN: ISSN 0092-8674
PubMed: 8861916
DOI: 10.1016/S0092-8674(00)81350-1