Zinc in PDB 9ubg: Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp

All present enzymatic activity of Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp:
6.4.1.1;

The binding sites of Zinc atom in the Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp (pdb code 9ubg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp, PDB code: 9ubg:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1102 b:72.7 occ:1.00 NE2 A:HIS732 2.3 55.8 1.0 NE2 A:HIS734 2.3 57.8 1.0 OD2 A:ASP533 2.6 63.3 1.0 CE1 A:HIS732 3.2 55.8 1.0 CD2 A:HIS734 3.2 55.1 1.0 CE1 A:HIS734 3.3 50.9 1.0 CD2 A:HIS732 3.4 53.0 1.0 NE2 A:GLN768 3.6 58.2 1.0 CG A:ASP533 3.7 61.0 1.0 NZ A:LYS703 3.8 37.8 1.0 OD1 A:ASP533 4.2 65.4 1.0 ND1 A:HIS732 4.3 57.2 1.0 ND1 A:HIS734 4.4 54.0 1.0 CG A:HIS734 4.4 55.4 1.0 CG A:HIS732 4.5 53.8 1.0 NH2 A:ARG532 4.8 48.9 1.0 CD A:GLN768 4.9 56.8 1.0 CB A:ASP533 4.9 54.1 1.0

Zinc binding site 2 out of 4 in the Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1102 b:70.8 occ:1.00 NE2 B:HIS732 2.3 53.6 1.0 NE2 B:HIS734 2.3 58.0 1.0 OD2 B:ASP533 2.6 62.7 1.0 CE1 B:HIS732 3.2 51.8 1.0 CD2 B:HIS734 3.2 57.9 1.0 CE1 B:HIS734 3.3 53.2 1.0 CD2 B:HIS732 3.3 54.3 1.0 NE2 B:GLN768 3.6 57.2 1.0 CG B:ASP533 3.7 63.1 1.0 NZ B:LYS703 3.8 40.1 1.0 OD1 B:ASP533 4.2 69.4 1.0 ND1 B:HIS734 4.4 54.2 1.0 CG B:HIS734 4.4 56.0 1.0 ND1 B:HIS732 4.4 57.5 1.0 CG B:HIS732 4.5 56.2 1.0 CD B:GLN768 4.8 55.4 1.0 NH2 B:ARG532 4.9 50.3 1.0 CB B:ASP533 4.9 54.4 1.0

Zinc binding site 3 out of 4 in the Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1103 b:73.4 occ:1.00 NE2 C:HIS732 2.3 55.5 1.0 NE2 C:HIS734 2.3 58.0 1.0 OD2 C:ASP533 2.6 65.1 1.0 CE1 C:HIS732 3.2 54.7 1.0 CD2 C:HIS734 3.2 55.7 1.0 CE1 C:HIS734 3.3 53.6 1.0 CD2 C:HIS732 3.4 55.7 1.0 NE2 C:GLN768 3.6 60.5 1.0 CG C:ASP533 3.7 63.8 1.0 NZ C:LYS703 3.8 40.0 1.0 OD1 C:ASP533 4.2 67.3 1.0 ND1 C:HIS732 4.3 58.3 1.0 ND1 C:HIS734 4.4 56.2 1.0 CG C:HIS734 4.4 57.1 1.0 CG C:HIS732 4.5 56.0 1.0 NH2 C:ARG532 4.9 53.5 1.0 CD C:GLN768 4.9 58.8 1.0 CB C:ASP533 4.9 58.0 1.0

Zinc binding site 4 out of 4 in the Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1103 b:72.9 occ:1.00 NE2 D:HIS732 2.3 55.5 1.0 NE2 D:HIS734 2.3 58.4 1.0 OD2 D:ASP533 2.6 64.0 1.0 CE1 D:HIS732 3.2 54.9 1.0 CD2 D:HIS734 3.2 56.2 1.0 CE1 D:HIS734 3.3 53.7 1.0 CD2 D:HIS732 3.4 52.8 1.0 NE2 D:GLN768 3.6 56.9 1.0 CG D:ASP533 3.7 62.4 1.0 NZ D:LYS703 3.8 40.9 1.0 OD1 D:ASP533 4.2 65.1 1.0 ND1 D:HIS732 4.3 57.2 1.0 ND1 D:HIS734 4.3 55.3 1.0 CG D:HIS734 4.4 55.7 1.0 CG D:HIS732 4.5 54.4 1.0 CD D:GLN768 4.8 54.1 1.0 NH2 D:ARG532 4.9 46.8 1.0 CB D:ASP533 4.9 54.2 1.0

A.Singh, D.Sharma, M.Raza, S.Singh, U.Das. Cryo-Em Structure of Pyruvate Carboxylase From Mycobacterium Tuberculosis in Complex with Acetyl-Coa and Adp To Be Published.